DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAPLA1 and Ddhd2

DIOPT Version :9

Sequence 1:	NP_609185.1	Gene:	PAPLA1 / 34109	FlyBaseID:	FBgn0031990	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	NP_082378.1	Gene:	Ddhd2 / 72108	MGIID:	1919358	Length:	699	Species:	Mus musculus

Alignment Length:	723	Identity:	287/723 - (39%)
Similarity:	409/723 - (56%)	Gaps:	115/723 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1354 MASASSEKGQVA-TPPVAIP----------------YSPVVAHWFYKRSVDTKFIWTPFSHYDSA 1401
            |:|..|.:.|:: :.|...|                |.||..||||.:.:|:|.:|.||:..||.
Mouse     1 MSSGESHQEQLSQSDPSPSPNSCSSFELIDMDASSSYEPVSPHWFYCKVLDSKELWIPFNSEDSQ 65

  Fly  1402 LLETSL--NLDDSTLIIPVEGGRYDVNIKERTKTPVYWEGKAIEVRRCSWFYKG-VDSKYVPYTE 1463
            .||.:.  ..|.:..|:|.:||||||::.||.:..|||:....|||||:||||| .|:|||||:|
Mouse    66 QLEDAYGSGKDCNERIVPTDGGRYDVHLGERMRYAVYWDELPSEVRRCTWFYKGDKDNKYVPYSE 130

  Fly  1464 DTAALLEAEYKRSAETGEWHQKIMLANGEQVVFHGPTVIVHFLPQQNADTWGASTQGSMRPRVVK 1528
            ..:.:||..|..:....||.:||...|.|.:|.|.|.::||:.|...:|.||:::....|||.||
Mouse   131 SFSQVLEDTYMLAVTLDEWKKKIESPNREIIVLHNPKLMVHYQPIAGSDEWGSTSTEQGRPRSVK 195

  Fly  1529 RDLDDFTIE--QGESQRVDHLLFMVHGIGSACDLKMRSVEEVVDDFRVIAQQLVQSHYKNSTDMG 1591
            |.:::..::  .||..::|||:|:|||||.||||:.||:.:.|:|||.::..|:|:|:|.:.:..
Mouse   196 RGVENIPVDIHCGEPLQIDHLVFVVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENE 260

  Fly  1592 LVGRVEVLPISWHGHLHSEELGIDEKLKSITLESIPRLRNFTNDTLLDVLFYTSPKYCQKIMNTV 1656
            .:||||.||::||..|||  .|:|..|:.|||.||.|||:|||||:|||.||.||.|||.|::||
Mouse   261 QIGRVEFLPVNWHSPLHS--TGVDIDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIVDTV 323

  Fly  1657 ADALNDVYLKYRMRHPEFNGGVSLAGHSLGSLILFDLLCHQ------------------------ 1697
            |..:|.:|..:..|:|:|.||||:||||||||||||:|.:|
Mouse   324 ASEMNRIYTLFLQRNPDFKGGVSIAGHSLGSLILFDILTNQKNSIGDIDSEKGSLSSAEDRGDAS 388

  Fly  1698 ---EPLKESE--------EENKENPDQL----------------PQK---------QSSQKVQLP 1726
               |.||:.:        |:.|.:.:.|                |:|         ::|..:..|
Mouse   389 TLEEDLKKLQLSEFVTVFEKEKVDREALALCTDRDLQEMGIPLGPRKKILNHFSARKNSVSINRP 453

  Fly  1727 TSDPLPKQVSYAMG---PEGTGQPVITYTQLIFHPKKFFALGSPIGMFVTIRGIDKLGLDFHLPT 1788
            ........:|...|   ..|.||..:.|.:|.:.|:.|||.|||||||:|:||:.::..::..||
Mouse   454 AMSASEVNISKENGDYLDVGIGQVSVKYPRLNYKPEIFFAFGSPIGMFLTVRGLRRIDPNYKFPT 518

  Fly  1789 CPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHKGRKRMHLELKETMTRVGADIKQRFMDT 1853
            |.||:||:|||||||||||.:|.|.:. ..|:|||||||||||||||:|.:||:..|:|...:.:
Mouse   519 CKGFFNIYHPFDPVAYRIEPMVAPGIE-FEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGS 582

  Fly  1854 FKTTLDSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQKQTEDQDESSVASSSCKLRNRTDSNST 1918
            .:....|   .|.......:|.|:.|             :||.:.|||...|         :.:.
Mouse   583 LRMAWKS---FTRGPYPALQASETAE-------------ETEAEPESSSEKS---------NEAN 622

  Fly  1919 TASDPEFIELDFPL--GKLNDSKRVDYVLQEAPLEFINEYIFALSSHVCYWGSEDTILFVMKEIY 1981
            |...|..::.:.|:  |.||..:|:||||||.|:|..|||:|||.||:|||.||||:|.|:||||
Mouse   623 TEEPPVEVKEEAPISVGMLNGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIY 687

  Fly  1982 ASLGISTD 1989
            .:.|:..|
Mouse   688 QTQGVFLD 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAPLA1	NP_609185.1	WWE	1377..1446	CDD:280915	29/70 (41%)
PAPLA1	NP_609185.1	DDHD	1758..1981	CDD:280937	100/224 (45%)
Ddhd2	NP_082378.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		6/23 (26%)
		WWE	42..112	CDD:367204	29/69 (42%)
		SAM_superfamily	383..447	CDD:387673	8/63 (13%)
		DDHD	487..687	CDD:367219	100/225 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	599..635		11/57 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846757
Domainoid	1	1.000	263	1.000	Domainoid score	I1925
eggNOG	1	0.900	-	-		E1_KOG2308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H66646
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003037
OrthoInspector	1	1.000	-	-		otm43851
orthoMCL	1	0.900	-	-		OOG6_104727
Panther	1	1.100	-	-	O	PTHR23509
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1772
SonicParanoid	1	1.000	-	-		X662
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.730