Protein Alignment PAPLA1 and sec23ip

DIOPT Version :10

• Sequence 1: NP_609185.1
• Gene: PAPLA1 / 34109
• FlyBaseID: FBgn0031990
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: NP_001070847.1
• Gene: sec23ip / 560750
• ZFINID: ZDB-GENE-030131-5259
• Length: 977
• Species: Danio rerio
• Alignment Length: 1130
• Identity: 370/1130 - (32%)
• Similarity: 525/1130 - (46%)
• Gaps: 311/1130 - (27%)

  Fly  1005 PTSANTTILTPAPDTTSTL-FANNIPTTTPSIPDIVPTTSAELVDAPPGFQGSSDDTA--TNLFQ 1066
            |:|:...:.:.||:...:| |   ||.:..:.|.::....|..|.....|.|.:..||  |:.|.
Zfish    10 PSSSANLLFSGAPEFNFSLPF---IPVSQATGPAVLSGEDASEVGEEDSFLGQTTSTAPQTSTFN 71

  Fly  1067 GNTETQTVFSPFAQTKATPLVQETKPELVPPPIGFFAPKS----ESEVLSQPPLAP-----SPLQ 1122
            ..:.|.....|||.     :.|::    .|||...|.|.:    .:.:.:..||.|     :|:|
Zfish    72 YFSNTANSSDPFAS-----IGQQS----CPPPAANFIPSTTGPLPASIAASLPLNPPVSHMNPVQ 127

  Fly  1123 SFFSTAPETATTTDFNFFGSPAPGSVFPDLPVQQGIAPPPLALESPPQNSVSNIATSAIGFDLLN 1187
            .:                     |||....|::....||......|||:|
Zfish   128 QY---------------------GSVANQAPMRTYTPPPNAPTPPPPQSS--------------- 156

  Fly  1188 QTQQASSLVENSNQNSSVNSFDGYFGGPSASAAQTFANETTNALVAPAINCDPVNFFDQVPQTQS 1252
              ||:.:...::..:|..|.:                      |:||.:...|.:   |.||
Zfish   157 --QQSYNPYRHTAVSSKANPY----------------------LMAPELQQQPPS---QTPQ--- 191

  Fly  1253 QIQQANEDQRIQNFFNNPPLQDQPAVPGELKYDIVHSGVAVKQLQERSQTPVSNLVEPPSSACSE 1317
                          ..||..|..|.                    ...|||.:...:||
Zfish   192 --------------HLNPYSQPTPT--------------------PSFQTPPTAFTKPP------ 216

  Fly  1318 FSTLAPAPTQTDRQSGDDLLQQHLGELPEDILRELRMASASSEKGQVATPPVAIPYS-----PVV 1377
             .|..|.|..|...:|.                            .|...|: :||:     ||.
Zfish   217 -PTQIPPPPPTTSMAGP----------------------------LVPANPM-MPYTYNVYEPVQ 251

  Fly  1378 AHWFYKRSVDTKFIWTPFSHYDSALLETSLNL---DDSTLIIPVEGGRYDVNIKERTKTPVYWEG 1439
            .||||.:.|::|.:|.|||..||..||.:.|.   |..::|:..:||||||.:.:||:|.||||.
Zfish   252 PHWFYCKQVESKIVWLPFSILDSIRLEETFNSVQPDPESVIVCTDGGRYDVQLYDRTRTSVYWEE 316

  Fly  1440 KAIEVRRCSWFYKG-VDSKYVPYTEDTAALLEAEYKRSAETGEWHQKIMLANGEQVVFHGPTVIV 1503
            ...|||||:||||| .||:::||:||.:..||||||::..|.:||:::...:||.:|.|.|.|||
Zfish   317 DPTEVRRCTWFYKGDTDSRFIPYSEDFSEKLEAEYKKAVTTNQWHRRLEFPSGETIVMHNPKVIV 381

  Fly  1504 HFLPQQNADTWGASTQGSMRPRVVKRDLDD--FTIEQGESQRVDHLLFMVHGIGSACDLKMRSVE 1566
            .|.|....|.||.:..|..|||||||.:||  ..:..||..:||||:|||||||..|||:.||:.
Zfish   382 QFQPSAVPDEWGTTQDGQTRPRVVKRGVDDDHDEVPDGEMPQVDHLVFMVHGIGPVCDLRFRSMV 446

  Fly  1567 EVVDDFRVIAQQLVQSHYKNSTDMGLVGRVEVLPISWHGHLHSEELGIDEKLKSITLESIPRLRN 1631
            |.|||||.::.:|:.||::.:.|..::.|||.||:.||..||.:..|:|.::|.|||.|..|||:
Zfish   447 ECVDDFRSVSLKLLNSHFRKARDDHVISRVEFLPVHWHTALHGDATGVDRRIKKITLPSTGRLRH 511

  Fly  1632 FTNDTLLDVLFYTSPKYCQKIMNTVADALNDVYLKYRMRHPEFNGGVSLAGHSLGSLILFDLLCH 1696
            |||:||||||||.||.|||.||:|||..:|.::..:..|:|:|.|.||:||||||||||||||.:
Zfish   512 FTNETLLDVLFYNSPTYCQTIMDTVAFEMNRLHTLFMQRNPDFKGRVSVAGHSLGSLILFDLLSN 576

  Fly  1697 QE---------------------------------PLKESEEENKENPDQ--------------- 1713
            |:                                 |:...|||.||..::
Zfish   577 QKIGSPISAPIFNGNSAPNVKQVNSAPEVQAAEVPPVAAVEEEAKEEEEEETGSLSSVLEAIGLS 641

  Fly  1714 ----------------------------LP------------------------QKQSSQKVQL- 1725
                                        :|                        :::|.:|.:|
Zfish   642 EYLSIFENEKIDVESLLMCTVDDLKEMSIPLGPRKKLANFIKEKSAKQAARKALKEKSVEKEELK 706

  Fly  1726 ---------PTSDP----LPK-------QVSYAMGPEGTGQPVITYTQLIFHPKKFFALGSPIGM 1770
                     ||.||    ||.       .|.|.....||||..:.|..|.|.|..||||||||||
Zfish   707 QTQAPVQTEPTPDPAINKLPVGRTMSSIHVDYNYFEIGTGQVSVIYHALDFEPVSFFALGSPIGM 771

  Fly  1771 FVTIRGIDKLGLDFHLPTCPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHKGRKRMHLEL 1835
            |:|:||::|:...:.||||.||:||:||.||||||||.::.||:: :.|||:||||||||:||||
Zfish   772 FLTVRGVEKIEESYQLPTCKGFFNIYHPLDPVAYRIEPMILPDID-LEPVLVPHHKGRKRLHLEL 835

  Fly  1836 KETMTRVGADIKQRFMDTFKTTLDSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQKQTEDQDES 1900
            ||:::|:|:|:||.|:.:.|:...::|..........:..|.|....:|..::  ::....::||
Zfish   836 KESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSVQLHEQLAMVANQIKAE--EEMQRGEEES 898

  Fly  1901 SVASSSCKLRNRTDSNSTTASDPEFIELD-FPLGKLNDSKRVDYVLQEAPLEFINEYIFALSSHV 1964
            .:..|               .:|:..|.. ..:|.||...|:||||||.|:|..|||:|||.||:
Zfish   899 KMLES---------------PEPQKEEESRIKVGLLNGGNRIDYVLQEKPIESFNEYLFALQSHL 948

  Fly  1965 CYWGSEDTILFVMKEIYASLGISTD 1989
            |||.||||.|.::||||.|:.|..|
Zfish   949 CYWESEDTALLLLKEIYKSMNIQPD 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAPLA1	NP_609185.1	PHA03247	<38..590	CDD:223021
		PHA03247	<375..1012	CDD:223021	2/6 (33%)
		Atrophin-1	888..>1179	CDD:460830	42/185 (23%)
		WWE	1379..1446	CDD:460715	32/69 (46%)
		DDHD	1754..1981	CDD:460725	101/227 (44%)
sec23ip	NP_001070847.1	WWE	253..323	CDD:460715	32/69 (46%)
		SAM_superfamily	628..688	CDD:472832	1/59 (2%)
		DDHD	755..965	CDD:460725	101/227 (44%)