DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PAPLA1 and PAPLA1

DIOPT Version :10

Sequence 1:NP_609185.1 Gene:PAPLA1 / 34109 FlyBaseID:FBgn0031990 Length:2016 Species:Drosophila melanogaster
Sequence 2:XP_061504615.1 Gene:PAPLA1 / 4577335 VectorBaseID:AGAMI1_003124 Length:1851 Species:Anopheles gambiae


Alignment Length:2229 Identity:745/2229 - (33%)
Similarity:976/2229 - (43%) Gaps:656/2229 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 NNNANQTRVVKNPLLSASVTGLSFDDFPNKPQLLPAAP-PVV-----HATPPAAPVLIAGILNRE 72
            ::.:.:..|:||||||:.||||:.|||.....|||||| |.:     .:|.|:.|.:.:.     
Mosquito    12 SDTSRKPPVIKNPLLSSQVTGLTLDDFAPVAVLLPAAPLPAIAKDPSESTAPSKPAIFSS----- 71

  Fly    73 PKSLVTVGQPSSIDDSEALDEINLNTSS-------------------EDSVGAGGSSPYLGAGDQ 118
             :..||...|....|:::..||:|..||                   |||.|..|...|...|:|
Mosquito    72 -QQTVTGTIPELPQDTDSFSEIDLTASSESQAPSRPPTIDYNPLQDLEDSDGRAGPVQYGDTGEQ 135

  Fly   119 NANPLLEPPTEAGNDSLLSQAASSFTALPAVASNVFSTFSKRIYAGSRETSEEPKLDIQPSYIQQ 183
            :....|:.     ..:|.:|.|:.   ||.|||.|||||| |:..|:  :...|.....|||...
Mosquito   136 SGGSYLQQ-----TSALTAQFAAQ---LPNVASTVFSTFS-RVIKGT--SPAPPPAAAPPSYAND 189

  Fly   184 AS-------YVQP-------------------VAPV-------PAPFYAAPPAAANE-------- 207
            .|       |..|                   :.|:       |:..:.|||..|.:        
Mosquito   190 PSAAHVVGTYGSPAEFQTTTPSSSNNNSNPSTLGPLINSSAYDPSSAFGAPPQTAPDDRQHSEGQ 254

  Fly   208 -VVAPEP--PKFYAPTEVPPPNVGVPAPPPTSGNPNTYRF-TARKKLYAPIPGLSEQSGQPAQQP 268
             ...|.|  |.||.|.:||.. .|:|.|....|..||||. .::||.||.||||:..:.||....
Mosquito   255 LAAGPPPPAPTFYNPEQVPSA-AGLPPPTAHGGISNTYRLGGSKKKTYAHIPGLNTTTAQPVLGS 318

  Fly   269 QVPQAPQAAPSFQTPP-----------YPPQLTYAANPAPFDISAQPAAIPAEERKSGGGLFSLT 322
            ....||.||  ..|||           |||:        |.::.....|.|.|..:...|..||.
Mosquito   319 AASSAPNAA--VPTPPVTHPFVTPSGHYPPE--------PVNLGEVKQAAPPENEELPKGKPSLL 373

  Fly   323 SLVPTGVLQNITGIVQSATGRSSEPEHTNVQQAGGYLDITTASAPAPSTNLFGGPNSTFP----- 382
            |.:|:.:|:.:                                 |.||   |||.....|     
Mosquito   374 SYLPSNILEKL---------------------------------PKPS---FGGEKKEEPAAPFT 402

  Fly   383 ---PGGNYF-----VPGAPPSLPSTGVVGPP----------SVGNFFAPAAPLPVAQTAAPPAV- 428
               |.|:..     |..||...|.|.|..||          :|.:||  ||| ||.:.|.||.| 
Mosquito   403 GGIPSGSIADQFVDVNAAPTGAPVTAVPPPPPLASATPLAATVPSFF--AAP-PVVEFAPPPVVA 464

  Fly   429 ------GAFFTSAAPSVTPSVFTPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGELF----- 482
                  ..|||:|||.         |..|..|           ::||.:.|.|:|...:|     
Mosquito   465 PAEASSSTFFTAAAPE---------TANPAGP-----------SVPPVSEPVAAAPPPVFFSPAQ 509

  Fly   483 VPAPTTIAQGTSPAVPFVDTQAV-------PTIPLTVP-------PGNPPPTSTLGGFFTTGEVA 533
            :|...|....:|.:.|:..|:|.       |..|:..|       |..|||.||           
Mosquito   510 IPTVRTAPSVSSKSNPYSSTRASGVGRYKNPLAPIVPPVAGAIFLPNQPPPLST----------- 563

  Fly   534 PVVAPFGTQASPATQSAGFFNPGEVRPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTASN 598
              ....|.|                    ||..|..|.|  ::|||| .:|.|            
Mosquito   564 --AHQLGAQ--------------------PLPPPSQTGP--TAGVPP-SIFTP------------ 591

  Fly   599 PNPLPGAAAPPPAAGQASYRLQKGTRLYKSPLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAP 663
                |.|||..|.|..::   |:|.:....||            |..||:..||: |.|...|||
Mosquito   592 ----PVAAASQPVALSSA---QEGNQPQPPPL------------ASAPPSIFTPS-FAPSANPAP 636

  Fly   664 GSFNSVGHLEGQSSQGVPFFTPPVQNPPGQVAAPTVAVPQSAPIAPPP----------------G 712
                            |..|.|....|   |.:.....||.:||.|||                |
Mosquito   637 ----------------VSIFNPTAPIP---VVSDKSEYPQQSPIPPPPSEGSVQPALIPVATYQG 682

  Fly   713 TSST----------SVAPPLTASIANPPPTS-------------GF-----ASVPLF-------- 741
            |:||          ::......||.||..|.             .|     |:.|||        
Mosquito   683 TASTQPESASVKAEAIHQSSLGSIFNPYATQQQPLEAQQVDTNLNFQQTVTATEPLFYKSENLPI 747

  Fly   742 AAPTISSTPIPFFNPQPTGAEVTTGLSQQENEATASTTLEGLVQGPAPTLSASQFFDTPLPTGTQ 806
            ||||.||.|:...:.|...|..:.|.:    .|.||...:|:...|:..|            ||:
Mosquito   748 AAPTASSFPLAAESVQNQFASFSIGTA----TAIASVASQGVNDFPSSFL------------GTE 796

  Fly   807 PENQ---------VASVSSERENLVQEPISNQGIPFFAPPQTNIFTPQLQQEFIAPAEDSKRSEI 862
            |...         |.|.|...||:.:.....||:..|     :|.|...    ||.......::.
Mosquito   797 PAQSPGSGTAKPIVDSRSKSSENVERRTSQRQGVASF-----SIGTATA----IASVASQGVNDF 852

  Fly   863 QEEFLSAPPQESNLSTELREDTHTGPPVIEPVLEETPASSSESSVPPASKVDQEDIVYPEPSAPV 927
            ...||...|.:|           .|....:|:::....||.....||           |.|::.:
Mosquito   853 PSSFLGTEPAQS-----------PGSGTAKPIVDSRSKSSENVLSPP-----------PRPNSNL 895

  Fly   928 EQEIPLFVPVPGLPGLSQDIPLYPPPPTGSTTASSIFAAPPVASSAPLFVPVPGPPSVSSLFSPS 992
            .:...:|      ||                      :.||    |.:|:|.|....::.|    
Mosquito   896 SEPAAIF------PG----------------------SVPP----ADIFLPDPQEEKLTQL---- 924

  Fly   993 QVDSTSSLFAPPPTSANTTILTPAPDTT-----STLFANNIPTTTPSIPDIVPTTSAELVDAPPG 1052
                                  ||.|..     |..|..|:  :.|:||.:...|:|..|     
Mosquito   925 ----------------------PAQDLNGNNGLSNFFGTNL--SQPAIPVVESQTNANFV----- 960

  Fly  1053 FQGSSDDTATNLFQGNTETQTVFSPFAQTKATPLVQETKPELVPPPIGFFAPKSESEVLSQPPLA 1117
            |..          |...|.|...:..|..:.||.:.         |:.||  .|.:.|    |.|
Mosquito   961 FPA----------QQPIEQQAKKTVLASPEPTPAIN---------PVDFF--NSNTIV----PQA 1000

  Fly  1118 PSPLQSFFSTAPETATTTDFNFFGSPAPGSVFPDLPVQQGIAPPPLALESPPQNSVSNIATSAIG 1182
            .:...:...|....::...|||||..|.              |.|.|:...|..||         
Mosquito  1001 DATEANTTKTGQTVSSVPLFNFFGRAAD--------------PAPPAVVHAPAESV--------- 1042

  Fly  1183 FDLLNQTQQASSLVENSNQNSSVNSFDGYFGGPSASAAQTFANETTNALVAPAINCDPVNFFDQV 1247
                       .|||::.:            ||...|..|.....|...|:.:::  .|:.|..:
Mosquito  1043 -----------PLVESTPK------------GPVKEATPTANTTATEQAVSSSVS--HVSSFSNL 1082

  Fly  1248 PQTQSQIQQANEDQRIQNFFNNPPLQDQPAVPGELKYDIVHSGVAVKQLQERSQTPVSNLVEPPS 1312
            ...:...:...|..||:      |..::|....:..:|...|.........|......:..:..|
Mosquito  1083 ANERYDEEGEQEPGRIE------PASNEPIFSSDNLFDFKASAYQDGGFYSRDTGRTYDTYDGNS 1141

  Fly  1313 SACSEFSTLAPA---PTQTDRQSGDDLLQQHLGELPEDILRELRMASASSEKGQVATPPVAIPYS 1374
            |..:..:|...|   .|.|....|..:                  |.:|:..         |.|.
Mosquito  1142 SMAAMATTSVGAQDTTTGTTNTGGTSI------------------AESSTTN---------IAYR 1179

  Fly  1375 PVVAHWFYKRSVDTKFIWTPFSHYDSALLETSL-------------NLDDSTLIIPVEGGRYDVN 1426
            |...||||:|.::.|.:|:||:..||..||..|             |..:..:|:..:||||||:
Mosquito  1180 PTYNHWFYRREIEGKSVWSPFTMADSMSLEDGLTTLQARGESADAENDGNPPVIVHTDGGRYDVS 1244

  Fly  1427 IKERTKTPVYWEGKAIEVRRCSWFYKGVDSKYVPYTEDTAALLEAEYKRSAETGEWHQKIMLANG 1491
            |:|||:|||||:|.|.||||||||||.|||::|||.|:.|.|||.|||.:|.:||||:::.:.||
Mosquito  1245 IRERTRTPVYWKGPANEVRRCSWFYKTVDSRFVPYEEEVADLLEREYKEAATSGEWHRRVTIPNG 1309

  Fly  1492 EQVVFHGPTVIVHFLPQQNADTWGAST----QGSMRPRVVKRDLDDFTIEQGESQRVDHLLFMVH 1552
            |.||||||:||||||..||.||||..:    ..:.|||||||.:|:|.|:..|.:::||||||||
Mosquito  1310 ETVVFHGPSVIVHFLQTQNPDTWGGGSSPVPSTTNRPRVVKRGIDEFNIDDDEPEKIDHLLFMVH 1374

  Fly  1553 GIGSACDLKMRSVEEVVDDFRVIAQQLVQSHYKNSTDMGLVGRVEVLPISWHGHLHSEELGIDEK 1617
            |||.||||:.|.||||||:||.|:.|||||||::|.|.|.|||||:||||||..|||||.|:|||
Mosquito  1375 GIGEACDLRFRRVEEVVDEFRSISAQLVQSHYRSSFDRGDVGRVEILPISWHDDLHSEESGVDEK 1439

  Fly  1618 LKSITLESIPRLRNFTNDTLLDVLFYTSPKYCQKIMNTVADALNDVYLKYRMRHPEFNGGVSLAG 1682
            ||||||.|||:||:|||||||||||||||.:||.|::.|..:||.:|..:..|:|.|:|.|||||
Mosquito  1440 LKSITLPSIPKLRHFTNDTLLDVLFYTSPMFCQSIIDAVGKSLNRLYALFCQRNPTFHGRVSLAG 1504

  Fly  1683 HSLGSLILFDLLCHQ---EPLKESEEENKENPDQLPQKQSSQKVQLPTSDPL------------- 1731
            |||||||||||||||   |..:..|.||.||||.            .|..||             
Mosquito  1505 HSLGSLILFDLLCHQKRAEQKQSCEPENSENPDD------------DTVSPLTPHHAFVNHRPLV 1557

  Fly  1732 ---PKQVSYAMGPEGTGQPVITYTQLIFHPKKFFALGSPIGMFVTIRGIDKLGLDFHLPTCPGFY 1793
               .:|::|.:||.|||||.|||.||:|.||.||||||||||||||||||.|||||.||||.||:
Mosquito  1558 RKCSQQINYEVGPAGTGQPYITYPQLMFQPKMFFALGSPIGMFVTIRGIDALGLDFKLPTCDGFF 1622

  Fly  1794 NIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHKGRKRMHLELKETMTRVGADIKQRFMDTFKTTL 1858
            |||||:||||||||||:|||::.:.||||||||||||||||||||:.|||.|::||..|.|:.||
Mosquito  1623 NIFHPYDPVAYRIEALINPDLSTLAPVLIPHHKGRKRMHLELKETVLRVGNDLRQRVTDVFRNTL 1687

  Fly  1859 DSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQKQTEDQDESSVASSSCKLRNRTDSNSTTASDP 1923
            |:|..||.:.  .|...::::||.        .|..:||.:...|.|:..|       |:..||.
Mosquito  1688 DTVYSLTAMG--SKPDPKAIQKEV--------DKVLQDQLKFDAAGSTSNL-------SSGTSDV 1735

  Fly  1924 EFIELDFPLGKLNDSKRVDYVLQEAPLEFINEYIFALSSHVCYWGSEDTILFVMKEIYASLGIST 1988
            :..|.:.||||||.|:||||||||||.||||||:|||:||||||.||||:||:|||||:|||:.|
Mosquito  1736 DSGETNLPLGKLNQSRRVDYVLQEAPFEFINEYLFALTSHVCYWDSEDTMLFLMKEIYSSLGVQT 1800

  Fly  1989 DSQVPQSSMTIERPVSHES 2007
            |.||||.:||||||::..|
Mosquito  1801 DHQVPQQTMTIERPLAGTS 1819

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PAPLA1NP_609185.1 PHA03247 <38..590 CDD:223021 178/681 (26%)
PHA03247 <375..1012 CDD:223021 167/746 (22%)
Atrophin-1 888..>1179 CDD:460830 56/295 (19%)
WWE 1379..1446 CDD:460715 35/79 (44%)
DDHD 1754..1981 CDD:460725 139/226 (62%)
PAPLA1XP_061504615.1 None

Return to query results.
Submit another query.