DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAPLA1 and Pitpnm3

DIOPT Version :9

Sequence 1:	NP_609185.1	Gene:	PAPLA1 / 34109	FlyBaseID:	FBgn0031990	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	XP_038943247.1	Gene:	Pitpnm3 / 287467	RGDID:	1308200	Length:	974	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	120/581 - (20%)
Similarity:	214/581 - (36%)	Gaps:	168/581 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1519 QGSMRPRVVKRDLDDFTIEQGESQR--VDHLLFMV-HG-----IGSACDLKMRSVEEVVDDFRVI 1575
            |||:.   :..|     :|:|.|||  ..|:|.:| ||     .||. |...::.:  :..|..:
  Rat   107 QGSIE---IHED-----VEEGCSQRSCKTHVLLLVLHGGNVLDTGSG-DPSCKAAD--IHTFSSV 160

  Fly  1576 AQQLVQSHYKNSTDMGLVGRVEVLPISWHGHLHSEELGI---------DEKLKSITLESIPRLRN 1631
            .:::.::|:..:....|:..|....|.      ||...:         ||...|.:.:.:|.
  Rat   161 LEKVTRAHFPAALGHILIKFVPCPAIC------SEAFSLVSNLNPYSHDEGCLSTSQDHVPL--- 216

  Fly  1632 FTNDTLLDVLFYTSPKYCQKIMNTVADALNDVYLKYRMRHPE---FNGGVSLAGHSLGSLILFDL 1693
                ..|.:|..:||:| |..:.||.:..|.:|.:: ::..:   |||.|.|.|..:|.|:.||.
  Rat   217 ----AALPLLAISSPQY-QDAVATVIERANHIYGEF-LKSSDGIGFNGQVCLIGDCVGGLLAFDA 275

  Fly  1694 LCHQEPLKESEEENKENPDQLPQKQSSQKVQ-----------LPTSDPLPK-QVSYAMGPE---- 1742
            :|:      |...:.::|....:|.|....|           |.:|..|.| .:..:.|.|
  Rat   276 ICY------SAGPSGDSPGSSSRKGSISSTQDTPVVVEEDCNLASSKRLSKSNIDVSSGVEDEDP 334

  Fly  1743 -----------------------------------------GTGQPVITYTQL---IFHPKKFFA 1763
                                                     ..|.|.::...|   .|....||.
  Rat   335 KRPLTRKQSDSSTYDCEAITQHHAFLSSIHSSVLKDEAEAPAAGTPQLSEVSLGRFDFDVSDFFL 399

  Fly  1764 LGSPIGMFVTIRGIDKLGLD-FHL-PTCPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHK 1826
            .|||:|:.:.:|.....|:| |.: |.|...|:.||..||.|.|:|.|:.|..:.:.||.:|.::
  Rat   400 FGSPLGLVLAMRRTVLPGIDGFQMRPACSQVYSFFHCADPSASRLEPLLEPKFHLVPPVSVPRYQ 464

  Fly  1827 GRKRMHLELKETMTRVGADIKQRFMDTFKTTLDSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQ 1891
                 ...|.:..:.:.||........|            :....:.:...|:...|...:...|
  Rat   465 -----RFPLGDGQSLLLADALHTHSPLF------------LEGSSRGSPPLLDAPASPPQAPRSQ 512

  Fly  1892 KQTEDQDESSVASSSCKLRNRTDSNSTTASDPEFIELDFPLG------KLNDSKRVDYVLQEAPL 1950
            :......|.|..|.|      ::|:.:.|          |:|      |...:||:||.|
  Rat   513 RPERRLSEGSSHSDS------SESSDSLA----------PMGASRITAKWWGTKRIDYAL----- 556

  Fly  1951 EFINEYIFALSS-------HVCYWGSEDTILFVMKEI--YASLGISTDSQVPQSSMTIERP 2002
             :..:.:.|..:       |..||.|.|.:.|:::::  |.|..:...:.:..::::...|
  Rat   557 -YCPDVLTAFPTVALPHLFHASYWESTDVVAFILRQVMRYESASVKESTGLDPTALSPANP 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAPLA1	NP_609185.1	WWE	1377..1446	CDD:280915
PAPLA1	NP_609185.1	DDHD	1758..1981	CDD:280937	53/239 (22%)
Pitpnm3	XP_038943247.1	DDHD	393..593	CDD:397132	53/238 (22%)
Pitpnm3	XP_038943247.1	LNS2	739..869	CDD:197870
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910