DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAPLA1 and DDHD2

DIOPT Version :9

Sequence 1:	NP_609185.1	Gene:	PAPLA1 / 34109	FlyBaseID:	FBgn0031990	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	NP_001157704.1	Gene:	DDHD2 / 23259	HGNCID:	29106	Length:	711	Species:	Homo sapiens

Alignment Length:	774	Identity:	294/774 - (37%)
Similarity:	418/774 - (54%)	Gaps:	152/774 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1295 QLQERSQTPVSNLVEPPSSACSEFSTLAPAPTQTDRQSGDDLLQQHLGELPEDILRELRMASASS 1359
            |.::.||:..|    |..::||.|                :|:....|.|
Human     7 QQEQLSQSDPS----PSPNSCSSF----------------ELIDMDAGSL--------------- 36

  Fly  1360 EKGQVATPPVAIPYSPVVAHWFYKRSVDTKFIWTPFSHYDSALLETSLNLDD--STLIIPVEGGR 1422
                         |.||..||||.:.:|:|..|.||:..||..||.:.:...  :..::|.:|||
Human    37 -------------YEPVSPHWFYCKIIDSKETWIPFNSEDSQQLEEAYSSGKGCNGRVVPTDGGR 88

  Fly  1423 YDVNIKERTKTPVYWEGKAIEVRRCSWFYKG-VDSKYVPYTEDTAALLEAEYKRSAETGEWHQKI 1486
            |||::.||.:..|||:..|.|||||:||||| .|:|||||:|..:.:||..|..:....||.:|:
Human    89 YDVHLGERMRYAVYWDELASEVRRCTWFYKGDKDNKYVPYSESFSQVLEETYMLAVTLDEWKKKL 153

  Fly  1487 MLANGEQVVFHGPTVIVHFLPQQNADTWGASTQGSMRPRVVKRDLDDFTIE--QGESQRVDHLLF 1549
            ...|.|.::.|.|.::||:.|...:|.||::.....|||.|||.:::.:::  .||..::|||:|
Human   154 ESPNREIIILHNPKLMVHYQPVAGSDDWGSTPTEQGRPRTVKRGVENISVDIHCGEPLQIDHLVF 218

  Fly  1550 MVHGIGSACDLKMRSVEEVVDDFRVIAQQLVQSHYKNSTDMGLVGRVEVLPISWHGHLHSEELGI 1614
            :|||||.||||:.||:.:.|:|||.::..|:|:|:|.:.:...:||||.||::||..|||  .|:
Human   219 VVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENQQIGRVEFLPVNWHSPLHS--TGV 281

  Fly  1615 DEKLKSITLESIPRLRNFTNDTLLDVLFYTSPKYCQKIMNTVADALNDVYLKYRMRHPEFNGGVS 1679
            |..|:.|||.||.|||:|||||:|||.||.||.|||.|::|||..:|.:|..:..|:|:|.||||
Human   282 DVDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIVDTVASEMNRIYTLFLQRNPDFKGGVS 346

  Fly  1680 LAGHSLGSLILFDLLCHQ---------------------------EPLKESE--------EENKE 1709
            :||||||||||||:|.:|                           |.||:.:        |:.|.
Human   347 IAGHSLGSLILFDILTNQKDSLGDIDSEKDSLNIVMDQGDTPTLEEDLKKLQLSEFFDIFEKEKV 411

  Fly  1710 NPDQL----------------PQKQ-----SSQKVQLPTSDPLPKQVSYAMGPE----------- 1742
            :.:.|                |:|:     |::|..:....|.|:..|.|..|:
Human   412 DKEALALCTDRDLQEIGIPLGPRKKILNYFSTRKNSMGIKRPAPQPASGANIPKESEFCSSSNTR 476

  Fly  1743 -------GTGQPVITYTQLIFHPKKFFALGSPIGMFVTIRGIDKLGLDFHLPTCPGFYNIFHPFD 1800
                   |.||..:.|.:||:.|:.|||.|||||||:|:||:.::..::..|||.||:||:||||
Human   477 NGDYLDVGIGQVSVKYPRLIYKPEIFFAFGSPIGMFLTVRGLKRIDPNYRFPTCKGFFNIYHPFD 541

  Fly  1801 PVAYRIEALVNPDMNGIRPVLIPHHKGRKRMHLELKETMTRVGADIKQRFMDTFKTTLDSVNFLT 1865
            |||||||.:|.|.:. ..|:|||||||||||||||:|.:||:..|:|...:.:.:....|.....
Human   542 PVAYRIEPMVVPGVE-FEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRAP 605

  Fly  1866 TVTKVKKEAEESLEKETSQTSSQAFQKQTEDQDESSVASSSCKLRNRTDSNSTTASDPEFIELDF 1930
            .......|..|..|.|...||.:.....||   |:|||...                 |.:.::
Human   606 YPALQASETPEETEAEPESTSEKPSDVNTE---ETSVAVKE-----------------EVLPIN- 649

  Fly  1931 PLGKLNDSKRVDYVLQEAPLEFINEYIFALSSHVCYWGSEDTILFVMKEIYASLGISTD 1989
             :|.||..:|:||||||.|:|..|||:|||.||:|||.||||:|.|:||||.:.||..|
Human   650 -VGMLNGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIYQTQGIFLD 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAPLA1	NP_609185.1	WWE	1377..1446	CDD:280915	28/70 (40%)
PAPLA1	NP_609185.1	DDHD	1758..1981	CDD:280937	100/222 (45%)
DDHD2	NP_001157704.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		5/20 (25%)
		WWE	42..112	CDD:308464	28/69 (41%)
		SAM_DDHD2	379..447	CDD:188984	10/67 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..470		5/20 (25%)
		DDHD	498..699	CDD:308481	100/223 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..638		9/31 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156355
Domainoid	1	1.000	264	1.000	Domainoid score	I1934
eggNOG	1	0.900	-	-		E1_KOG2308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H66646
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003037
OrthoInspector	1	1.000	-	-		otm41799
orthoMCL	1	0.900	-	-		OOG6_104727
Panther	1	1.100	-	-	O	PTHR23509
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1772
SonicParanoid	1	1.000	-	-		X662
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.730