DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PAPLA1 and Sec23ip

DIOPT Version :9

Sequence 1:NP_609185.1 Gene:PAPLA1 / 34109 FlyBaseID:FBgn0031990 Length:2016 Species:Drosophila melanogaster
Sequence 2:NP_001025153.2 Gene:Sec23ip / 207352 MGIID:2450915 Length:998 Species:Mus musculus


Alignment Length:1141 Identity:379/1141 - (33%)
Similarity:521/1141 - (45%) Gaps:309/1141 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1006 TSANTTILTPAPDTTSTLFANNIPTTTPSIPDIVPTTSAELVDAP---PGFQGSSDDTATNLFQG 1067
            :|:.|.:|.   .:::|.|:.|:|        .:|.|.|....|.   || :.|:|....:.|.|
Mouse    14 SSSGTNLLF---SSSATEFSFNVP--------FIPVTQAAASPASLLLPG-EDSTDVGEEDSFLG 66

  Fly  1068 NTETQT----VFSPFAQTKATPLVQETKPELVPPPIGFFAPKSESEVLSQPPLAPSPLQSFFSTA 1128
            .|.|.|    .||.|:|..::           ..|.|         .:.|.||..|.:.:..|..
Mouse    67 QTSTHTSTPQTFSYFSQVSSS-----------SDPFG---------NIGQSPLTTSAMSAGQSAL 111

  Fly  1129 PETATTTDFNFFGSPAPGSVFPDLPVQQGIAPPPLALESPPQNSVSNIATSAIGFDLLNQTQQAS 1193
            |:...|..|. .||....|.|           ||...::|.....|.:.||..      ...|.|
Mouse   112 PKPPATLAFT-TGSQDALSAF-----------PPSVSKAPGATPPSQMGTSTY------LPSQPS 158

  Fly  1194 SLVENSNQNSSVNSFDGYFGGPSASAAQTFANETTNALVAPAINCDPVNFFDQVPQTQSQIQQAN 1258
            ||..|             ||.|.....|...|...:.         ||:            .:||
Mouse   159 SLPPN-------------FGSPPQGIPQQGHNPYRHT---------PVS------------SRAN 189

  Fly  1259 EDQRIQNFFNNPPLQDQPAVPGELKYDIVHSGVAVKQLQERSQTPVSNLVEPPSSACSEFSTLAP 1323
            .       :..||...|..:||...|            ...|..||.....||       ..|.|
Mouse   190 P-------YITPPQLQQCQMPGHSSY------------PPPSGPPVQTYQMPP-------GPLPP 228

  Fly  1324 APTQTDRQSGDDLLQQHLGELPEDILRELRMASASSEKGQVATPPVAIP--------YSPVVAHW 1380
            .||.....:     ||.:...|                   |.|.|..|        |.||..||
Mouse   229 LPTAMQSPA-----QQQVPARP-------------------AGPLVQGPSPFVLQNQYEPVQPHW 269

  Fly  1381 FYKRSVDTKFIWTPFSHYDSALLE---TSLNLDDSTLIIPVEGGRYDVNIKERTKTPVYWEGKAI 1442
            ||.:.|:.|.:|.|||..||..||   .|:..|..::::..:||||||.:.:|.:..||||.:..
Mouse   270 FYCKEVEYKQLWMPFSVLDSLNLEEIYNSVQPDPESVVLGTDGGRYDVYLYDRMRKSVYWEEEPT 334

  Fly  1443 EVRRCSWFYKG-VDSKYVPYTEDTAALLEAEYKRSAETGEWHQKIMLANGEQVVFHGPTVIVHFL 1506
            |||||:||||| .||:::||||:.:..||||||::..|.:||:::...:||.:|.|.|.|||.|.
Mouse   335 EVRRCTWFYKGDTDSRFIPYTEEFSEKLEAEYKKAVSTNQWHRRLEFPSGETIVMHNPKVIVQFQ 399

  Fly  1507 PQQNADTWGASTQGSMRPRVVKRDLDDF--TIEQGESQRVDHLLFMVHGIGSACDLKMRSVEEVV 1569
            |....|.||.:..|..|||||||.:||.  .|..||..:||||:|||||||..|||:.||:.|.|
Mouse   400 PSSVPDEWGTTQDGQTRPRVVKRGIDDSLDEIPDGEMPQVDHLVFMVHGIGPVCDLRFRSIIECV 464

  Fly  1570 DDFRVIAQQLVQSHYKNSTDMGLVGRVEVLPISWHGHLHSEELGIDEKLKSITLESIPRLRNFTN 1634
            |||||::.:|:|:|:|.|.|.|.|.|||.||:.||..|.....|:|..:|.|||.||.|.|:|||
Mouse   465 DDFRVVSLKLLQTHFKKSVDEGKVSRVEFLPVHWHSALGGHATGVDRNIKKITLPSIGRFRHFTN 529

  Fly  1635 DTLLDVLFYTSPKYCQKIMNTVADALNDVYLKYRMRHPEFNGGVSLAGHSLGSLILFDLLCHQEP 1699
            :||||||||.||.|||.|:..|...:|.::..:..|:|.|.|.||:||||||||||||:|.:|..
Mouse   530 ETLLDVLFYNSPTYCQAIVEKVEVEINRLHSLFMSRNPNFKGKVSVAGHSLGSLILFDILSNQRD 594

  Fly  1700 ----------------LKESE-------EENK-------------ENP----------------- 1711
                            :|.|:       ||:|             |.|                 
Mouse   595 MCVSKSPGSVAVSNGVIKHSQFQEKLISEESKLMSDESCDLDVEDEEPLTLHGTLEALSLFDYIS 659

  Fly  1712 -----------------DQL--------PQKQSSQKVQLPTS----------------------- 1728
                             |.|        |:|:.:..|:|..:                       
Mouse   660 TFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVKLKAAKLEQKKAAAEKKAALAALTKGQD 724

  Fly  1729 DPLPK---------------------------QVSYAMGPEGTGQPVITYTQLIFHPKKFFALGS 1766
            :..||                           :|.|.....||||..:.|:.|.|.|:.||||||
Mouse   725 ESAPKTKEMASPSSESNESKRKLSVGAYVSSVRVDYESFEVGTGQVSVAYSSLDFEPEIFFALGS 789

  Fly  1767 PIGMFVTIRGIDKLGLDFHLPTCPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHKGRKRM 1831
            ||||.:||||:.::...:.||||.||:||:||.||||||:|.::.||:: ::.||:||||||||:
Mouse   790 PIGMLLTIRGVARIDEKYRLPTCKGFFNIYHPLDPVAYRLEPMIAPDLD-LKAVLVPHHKGRKRL 853

  Fly  1832 HLELKETMTRVGADIKQRFMDTFKTTLDSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQKQTED 1896
            ||||||:::|:|:|:||.|:.:.|:...::|..........:.:|.|||..:         |.::
Mouse   854 HLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSTTQLQEELEKVAN---------QIKE 909

  Fly  1897 QDESSVASSSCKLRNRTDSNSTTASDPEFIELDFPLGK---LNDSKRVDYVLQEAPLEFINEYIF 1958
            ::|..|..:           ......||..:.:..|||   ||..:|:||||||.|:|..|||:|
Mouse   910 EEEKQVVEA-----------EKIVESPELSKDEDYLGKVGMLNGGRRIDYVLQEKPIESFNEYLF 963

  Fly  1959 ALSSHVCYWGSEDTILFVMKEIYASLGISTDSQVPQ 1994
            ||.||:||||||||.|.::||||.::.||.:.  ||
Mouse   964 ALQSHLCYWGSEDTALLLLKEIYRTMNISPEQ--PQ 997

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PAPLA1NP_609185.1 WWE 1377..1446 CDD:280915 29/71 (41%)
DDHD 1758..1981 CDD:280937 100/225 (44%)
Sec23ipNP_001025153.2 Interaction with SEC23A. /evidence=ECO:0000250 1..363 126/482 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..246 65/318 (20%)
SAM_superfamily 634..702 CDD:301707 8/67 (12%)
SAM 649..700 CDD:197735 6/50 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 720..742 2/21 (10%)
DDHD 780..986 CDD:280937 100/226 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846758
Domainoid 1 1.000 210 1.000 Domainoid score I2813
eggNOG 1 0.900 - - E1_KOG2308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003037
OrthoInspector 1 1.000 - - otm43851
orthoMCL 1 0.900 - - OOG6_104727
Panther 1 1.100 - - LDO PTHR23509
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1772
SonicParanoid 1 1.000 - - X662
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.730

Return to query results.
Submit another query.