Protein Alignment PAPLA1 and ipla-1

DIOPT Version :10

• Sequence 1: NP_609185.1
• Gene: PAPLA1 / 34109
• FlyBaseID: FBgn0031990
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: NP_001367817.1
• Gene: ipla-1 / 173795
• WormBaseID: WBGene00019747
• Length: 840
• Species: Caenorhabditis elegans
• Alignment Length: 867
• Identity: 208/867 - (23%)
• Similarity: 333/867 - (38%)
• Gaps: 230/867 - (26%)

  Fly  1275 QPAVPGELKYDIVHSGVAVKQLQERSQTPVSNLVEPPSSACSEFSTLAP----APTQTDRQSGDD 1335
            |...|.|.:.:.|:... |:..::.|:      |..|::......|..|    .|||.|......
 Worm    30 QKEKPKEKQMEFVNQNF-VESTEDESE------VSTPTAVGLPIGTSTPDGDETPTQPDPNGKYT 87

  Fly  1336 LLQQHLGEL--PEDILRELRMASA-----SSEKGQVATP-PVAIPYSP-------------VVAH 1379
            :.|....:|  |..:.......|:     :|:.|.||.| |...|.:|             ....
 Worm    88 MAQTKDADLSRPSGLPSNGNPGSSTTVPPASKSGPVAPPRPSGTPVAPQRNRRRKVTELKCSEVR 152

  Fly  1380 WFYKRSVDTKFIWTPFSHYDSALL------ETSLNLD-------DSTL----------------- 1414
            ||::....|  :|.||:..||.:|      |..:.||       |.:|
 Worm   153 WFFQEPKGT--LWNPFNGRDSIMLEIKYRKEKGIELDEAMQEIYDESLTHYKMEMKDEPEIENGN 215

  Fly  1415 --------IIPVEGGRYDVNIKERTK-TPVYWEGKAIEVRRCSWF---YKGVD------------ 1455
                    ::.|..|:|.|| |:.:| .|:||:..:.|:||.|||   |:.::
 Worm   216 IGMEQEKPMVVVMNGQYKVN-KDNSKIDPIYWKDDSKEIRRGSWFSPDYQPLEMPLSDQIEKNHL 279

  Fly  1456 ----SKYVPYTEDTAALLEAEYKRSAETGEWH---QKIMLANGEQVVFHGP-TVIVHFLPQQNAD 1512
                ::.:|  |.|....::|........|.|   ..|..::...:..|.. ..|:.:|
 Worm   280 QCFRNQMIP--EGTTVFSKSETSNKPVLAELHVDGYDIRWSSVIDISLHQKGNAILRYL------ 336

  Fly  1513 TWGASTQGSMRPRVVKR-DLDDFTIEQGESQRVDHLLFMVHGIGSAC--DLKMRSVEEVVDDFRV 1574
             |..||  .:|....|. |.:|...|      :.||:.:|||||...  :|..::..:|.|.. |
 Worm   337 -WAKST--PLRRGYEKEADWNDAAAE------ISHLILVVHGIGQKGYENLIAQNANQVRDGV-V 391

  Fly  1575 IAQQLVQSHYKNSTDMGLVGRVEVLPISWHGHLHSEELGIDEKLKSITLESIPRLRNFTNDTLLD 1639
            .|.:.|....|:        |...||:.|...|..:. |:.:   :||:..:..:|...|.|.:|
 Worm   392 SAMEKVYPEEKS--------RPMFLPVEWRSALKLDN-GLTD---NITIPKMSSMRASLNSTAMD 444

  Fly  1640 VLFYTSPKYCQKIMNTVADALNDVYLKYRMRHPEFNGGVSLAGHSLGSLILFDLLCHQEPL---- 1700
            |::|.||.:..:|:..|...||..|..::..:|:|||.||:.||||||:|.:|:|....||
 Worm   445 VMYYQSPLFRTEIVRGVVSQLNRTYKLFKANNPQFNGHVSVFGHSLGSVICYDVLTQYSPLMLFD 509

  Fly  1701 ---KESEEENKENPDQLPQKQSSQKVQL------PTSDPLPKQVSYAMGPEGTGQPVITYTQLIF 1756
               .:|.:|..:..|....:::.:.::.      ...|.|...:...:        |....||.|
 Worm   510 KYVTKSIDEYLKRDDTNASEEARKALEAMKLAREQLRDNLEGGIHKLL--------VTKEEQLEF 566

  Fly  1757 HPKKFFALGSPIGMFVTIRGIDKLGLDFHLPTCPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVL 1821
            ..|..||:|||:|:|:|:||.:...|..........:|||||:||||||:|....|:...|||:.
 Worm   567 KVKYLFAVGSPLGVFLTMRGGESTDLLSKATNVERVFNIFHPYDPVAYRLEPFFAPEYRHIRPIK 631

  Fly  1822 IPHHKGRKRMHLELKETMTRVGADIKQRFMDTFKTTLDSVNFLTTVTKVKKEAEESLEKETSQTS 1886
            :            ...|..|..|..:...:|.:|..|..   |..:.|.||..::    :|:...
 Worm   632 L------------FSNTDLRARASYENLPLDVYKHYLKK---LKNLNKAKKNKDD----KTADAR 677

  Fly  1887 SQAFQKQTEDQDE---SSVASSSCKL-RNRTD-------SNST-----------------TASDP 1923
            |.. ..:.||:||   ...|.|.|.. |:.|.       :|:.                 |:|:|
 Worm   678 SGG-DDENEDEDECDSDEDARSGCSSPRSMTPPPFETAAANAAAAAKETKAVKKGWFSFGTSSNP 741

  Fly  1924 EFIELDFPLGKLNDSK-----------------------------RVDYVLQEAPLEFINEYIFA 1959
            :..:....||.:|.:.                             |:|:.||.|..|  ..|...
 Worm   742 KKTQSTASLGSVNATSTENIEFAKEAAEELPLAEKILGSGVRVPHRIDFQLQPALTE--KSYWSV 804

  Fly  1960 LSSHVCYWGSEDTILFVMKEIY 1981
            |.||..||.:.|..||:...:|
 Worm   805 LKSHFAYWTNADLALFLANVLY 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAPLA1	NP_609185.1	PHA03247	<38..590	CDD:223021
		PHA03247	<375..1012	CDD:223021
		Atrophin-1	888..>1179	CDD:460830
		WWE	1379..1446	CDD:460715	25/105 (24%)
		DDHD	1754..1981	CDD:460725	73/283 (26%)
ipla-1	NP_001367817.1	Mucin-like	<71..137	CDD:464997	17/65 (26%)
		DDHD	564..826	CDD:460725	73/283 (26%)