DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAPLA1 and Ddhd1

DIOPT Version :9

Sequence 1:	NP_609185.1	Gene:	PAPLA1 / 34109	FlyBaseID:	FBgn0031990	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	NP_001036184.1	Gene:	Ddhd1 / 114874	MGIID:	2150302	Length:	918	Species:	Mus musculus

Alignment Length:	968	Identity:	216/968 - (22%)
Similarity:	356/968 - (36%)	Gaps:	290/968 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1210 GYFGGPSASAAQTFANETTNALVAPAINCDPVNFFDQVPQTQSQIQQANEDQRIQNFFNNPPLQD 1274
            |.|||...    .|.::..:::....:..:|::           :....:|  :.:...:|.|.|
Mouse    30 GVFGGGGC----CFEHQPGDSVPLSLLRAEPLH-----------LAPGADD--LSHLALDPCLSD 77

  Fly  1275 QPAVPGELKYDI--VHSGVAVKQLQERSQTPVSNLVEPPSSACSEFSTLAPAPTQTDRQSGDDLL 1337
            :       .||.  ..||.:::...|            ..||....|:..|.|.......|...
Mouse    78 E-------TYDFSSAESGSSLRYYSE------------GESAGGGSSSSPPPPLVAQNSGGGGA- 122

  Fly  1338 QQHLGELPEDILRELRMASASSEKGQVATPPVAIPYSPVVAHWFYKRSVDTKFIWTPFSHYDSAL 1402
               .|..|.|..|.....:|:..:.:|.|     ...|....||||   :.|..|.||..|||..
Mouse   123 ---AGGGPGDRKRARPGGAAARHRYEVVT-----ELGPEEVRWFYK---EDKKTWKPFIGYDSLR 176

  Fly  1403 LETSL-------------------------------------------------NLDDSTLIIP- 1417
            :|.:.                                                 .:::...|.|
Mouse   177 IELAFRTLLQTTGAQARAAGRDGDRVCGPSSSFGEEDEEDSACGFCPRAAGPEPEMEELVTIEPV 241

  Fly  1418 -VEGGRYDVNIKERTKTPVYW-EGKAIEVRRCSWFYKGVDSKYVPYTEDTAALLEAEYKRSAETG 1480
             |.||.|:|::.:....|||| :...|.|.|..||   :|..:.|..|:.:.|:|.|: .|...|
Mouse   242 CVRGGLYEVDVTQGECYPVYWNQADKIPVMRGQWF---IDGTWQPLEEEESNLIEQEH-LSCFRG 302

  Fly  1481 EWHQK---IMLA---NGEQVVFHGP--------------------------TVIVH-FLPQQNAD 1512
            :..|:   |.::   :|:.||:|.|                          :..|| |...:|..
Mouse   303 QQMQENFDIEVSKSLDGKDVVYHLPPFSLPSLFKWRGYKESTDATGLKRKRSQAVHSFKLSRNHV 367

  Fly  1513 TW-------------------------GASTQGSMRPRVVKRDLDDFTIEQGESQRVDHLLFMVH 1552
            .|                         |.|...|...|:.:..:::.|:|...|| ..|::|:||
Mouse   368 DWHSMDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQ-TSHIVFVVH 431

  Fly  1553 GIGSACDLKMRSVEEVVDDFRVIAQQLVQSHYKNSTDMGLVGRVEVLPISWHGHLHSEELGIDEK 1617
            |||...| :.|.::... ..|..|:::.:.|:.|...     .||.||:.|...|..:...:|
Mouse   432 GIGQKMD-QGRIIKNTA-MMREAARKMEEKHFSNHAT-----HVEFLPVEWRSKLTLDGDTVD-- 487

  Fly  1618 LKSITLESIPRLRNFTNDTLLDVLFYTSPKYCQKIMNTVADALNDVYLKYRMRHPEF---NGGVS 1679
              |||.:.:..||:..|.:.:|:::||||.|..:::..:...||.:|..:..|:|:|   .|.||
Mouse   488 --SITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPDFEEKGGKVS 550

  Fly  1680 LAGHSLGSLILFDLLCHQEP------LKESEEENKENPDQLPQKQSSQKVQLPTSDPL------P 1732
            :..||||.:|.:|::....|      |.:.|||       ||.::.....:....|.|      .
Mouse   551 IVSHSLGCVITYDIMMGWNPGGLYEQLLQKEEE-------LPDERWMSYEERHLLDELYITKRRL 608

  Fly  1733 KQVSYAMGPEGTGQPVITYT-QLIFHPKKFFALGSPIGMFVTIRGI---DKLGLDFHLP--TCPG 1791
            :::...:  .|...|.|:.| .|.|..:.||.:|||:.:|:.:|||   :....|..||  .|..
Mouse   609 REIEDRL--HGLKAPSISQTPALKFKVENFFCMGSPLAVFLALRGIRPGNSGSQDHILPREICNR 671

  Fly  1792 FYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHKGRKRMHLELKETMTRVGADIKQRFMDTFK- 1855
            ..|||||.||||||:|.|:....:.|.||.|..:.....:..|          .:|..|::..|
Mouse   672 LLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYE----------HMKPNFLNPAKE 726

  Fly  1856 --TTLDSVNF--------------------LTTVTKVKKEAEESLEK------------ETSQTS 1886
              :..||.|.                    :|.:.|.......|:.|            .::...
Mouse   727 PTSVSDSENIAAIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQP 791

  Fly  1887 SQAFQKQTEDQDESSVASSSCKLRNRT---------DS-------------------NSTTASDP 1923
            |:..:...||..:.|.:.|:..:..:|         ||                   |...:.|.
Mouse   792 SEPSKDSLEDDKKPSASPSTTTVATQTLPHSGSGFLDSAYFRLQESFFYLPQLLFPENVMQSKDD 856

  Fly  1924 EFIELDFPLGKLNDSKRVDYVLQEAPLEFINEYIFALSSHVCYWGSEDTILFVMKEIY 1981
            ..:||:         .|:|:.|:|..:|  :.|..|::||..||.|.|..||::..:|
Mouse   857 SLVELE---------HRIDFELREGLVE--SRYWSAVTSHTAYWSSLDVALFLLTFMY 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAPLA1	NP_609185.1	WWE	1377..1446	CDD:280915	25/120 (21%)
PAPLA1	NP_609185.1	DDHD	1758..1981	CDD:280937	68/290 (23%)
Ddhd1	NP_001036184.1	DDHD	632..903	CDD:280937	68/291 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4901
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1772
SonicParanoid	1	1.000	-	-		X662
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.790