Protein Alignment PAPLA1 and SEC23IP

DIOPT Version :10

• Sequence 1: NP_609185.1
• Gene: PAPLA1 / 34109
• FlyBaseID: FBgn0031990
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: NP_009121.1
• Gene: SEC23IP / 11196
• HGNCID: 17018
• Length: 1000
• Species: Homo sapiens
• Alignment Length: 1145
• Identity: 375/1145 - (32%)
• Similarity: 526/1145 - (45%)
• Gaps: 317/1145 - (27%)

  Fly  1006 TSANTTILTPAPDTTSTLFANNIPTTTPSIPDIVPTTSAELVDAP---PGFQGSSDDTATNLFQG 1067
            :|:.|.:|.   .:::|.|:.|:|        .:|.|.|....|.   || :.|:|....:.|.|
Human    16 SSSGTNLLF---SSSATEFSFNVP--------FIPVTQASASPASLLLPG-EDSTDVGEEDSFLG 68

  Fly  1068 NTETQT----VFSPFAQTKATPLVQETKPELVPPPIGFFAPKSESEVLSQPPL---APSPLQSFF 1125
            .|...|    .||.|:|..::           ..|.|         .:.|.||   |.|..||.|
Human    69 QTSIHTSAPQTFSYFSQVSSS-----------SDPFG---------NIGQSPLTTAATSVGQSGF 113

  Fly  1126 STAPETATTTDFNFFGSPAPGSVFPDLPVQQGIAPPPLALESPPQNSVSNIATSAIGFDLLNQTQ 1190
               |:..|...|.........:..|.:...|..|||                :|.:|.:....:|
Human   114 ---PKPLTALPFTTGSQDVSNAFSPSISKAQPGAPP----------------SSLMGINSYLPSQ 159

  Fly  1191 QAS---SLVENSNQNSSVNSFDGYFGGPSASAAQTFANETTNALVAPAINCDPVNFFDQVPQTQS 1252
            .:|   |...|..|......::.|...|.:|.|        |..:||                 .
Human   160 PSSLPPSYFGNQPQGIPQPGYNPYRHTPGSSRA--------NPYIAP-----------------P 199

  Fly  1253 QIQQANEDQRIQNFFNNPPLQDQPAVPGELKYDIVHSGVAVKQLQERSQTPVSNLVEPPSSACSE 1317
            |:||....        .||....|:.|....|                |.|..:|...|||..|
Human   200 QLQQCQTP--------GPPAHPPPSGPPVQMY----------------QMPPGSLPPVPSSVQS- 239

  Fly  1318 FSTLAPAPTQTDRQSGDDLLQQHLGELPEDILRELRMASASSEKGQVATPPVAIP--------YS 1374
                 ||..|...:.|                                .|.|.:|        |.
Human   240 -----PAQQQVPARPG--------------------------------APSVQVPSPFLLQNQYE 267

  Fly  1375 PVVAHWFYKRSVDTKFIWTPFSHYDSALLE---TSLNLDDSTLIIPVEGGRYDVNIKERTKTPVY 1436
            ||..||||.:.|:.|.:|.|||.:||..||   .|:..|..::::..:||||||.:.:|.:...|
Human   268 PVQPHWFYCKEVEYKQLWMPFSVFDSLNLEEIYNSVQPDPESVVLGTDGGRYDVYLYDRIRKAAY 332

  Fly  1437 WEGKAIEVRRCSWFYKG-VDSKYVPYTEDTAALLEAEYKRSAETGEWHQKIMLANGEQVVFHGPT 1500
            ||.:..|||||:||||| .||:::||||:.:..||||||::..|.:||:::...:||.:|.|.|.
Human   333 WEEEPAEVRRCTWFYKGDTDSRFIPYTEEFSEKLEAEYKKAVTTNQWHRRLEFPSGETIVMHNPK 397

  Fly  1501 VIVHFLPQQNADTWGASTQGSMRPRVVKRDLDD--FTIEQGESQRVDHLLFMVHGIGSACDLKMR 1563
            |||.|.|....|.||.:..|..|||||||.:||  ..|..||..:||||:|:|||||..|||:.|
Human   398 VIVQFQPSSVPDEWGTTQDGQTRPRVVKRGIDDNLDEIPDGEMPQVDHLVFVVHGIGPVCDLRFR 462

  Fly  1564 SVEEVVDDFRVIAQQLVQSHYKNSTDMGLVGRVEVLPISWHGHLHSEELGIDEKLKSITLESIPR 1628
            |:.|.||||||::.:|:::|:|.|.|.|.|.|||.||:.||..|..:..|:|..:|.|||.||.|
Human   463 SIIECVDDFRVVSLKLLRTHFKKSLDDGKVSRVEFLPVHWHSSLGGDATGVDRNIKKITLPSIGR 527

  Fly  1629 LRNFTNDTLLDVLFYTSPKYCQKIMNTVADALNDVYLKYRMRHPEFNGGVSLAGHSLGSLILFDL 1693
            .|:|||:||||:|||.||.|||.|:..|...:|.::..:..|:|:|.||||:||||||||||||:
Human   528 FRHFTNETLLDILFYNSPTYCQTIVEKVGMEINHLHALFMSRNPDFKGGVSVAGHSLGSLILFDI 592

  Fly  1694 LCHQEPL-----------------------KESEEENK-----------ENPDQLP--------- 1715
            |.:|:.|                       |:..||.|           ||.:.|.
Human   593 LSNQKDLNLSKCPGPLAVANGVVKQLHFQEKQMPEEPKLTLDESYDLVVENKEVLTLQETLEALS 657

  Fly  1716 ----------------------------------------------------------------- 1715
                                                                             
Human   658 LSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAKLKKAASEKKAVAATST 722

  Fly  1716 --QKQSSQKVQ----LPTSDPLPKQ------------VSYAMGPEGTGQPVITYTQLIFHPKKFF 1762
              |:||:||.:    ||:....||:            |:|.....|.||..:.|..|.|.|:.||
Human   723 KGQEQSAQKTKDMASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFF 787

  Fly  1763 ALGSPIGMFVTIRGIDKLGLDFHLPTCPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHKG 1827
            ||||||.||:||||:|::..::.||||.||:||:||.||||||:|.::.||:: ::.||||||||
Human   788 ALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPLDPVAYRLEPMIVPDLD-LKAVLIPHHKG 851

  Fly  1828 RKRMHLELKETMTRVGADIKQRFMDTFKTTLDSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQK 1892
            |||:||||||:::|:|:|:||.|:.:.|:...::|..........:.:|.|||..:
Human   852 RKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVAN--------- 907

  Fly  1893 QTEDQDESSVASSSCKLRNRTDSNSTTASDPEFIELDFPLGK---LNDSKRVDYVLQEAPLEFIN 1954
            |.::::|..|..:           ......|:|.:.:..|||   ||..:|:||||||.|:|..|
Human   908 QIKEEEEKQVVEA-----------EKVVESPDFSKDEDYLGKVGMLNGGRRIDYVLQEKPIESFN 961

  Fly  1955 EYIFALSSHVCYWGSEDTILFVMKEIYASLGISTDSQVPQ 1994
            ||:|||.||:|||.||||.|.::||||.::.||.:.  ||
Human   962 EYLFALQSHLCYWESEDTALLLLKEIYRTMNISPEQ--PQ 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAPLA1	NP_609185.1	PHA03247	<38..590	CDD:223021
		PHA03247	<375..1012	CDD:223021	2/5 (40%)
		Atrophin-1	888..>1179	CDD:460830	41/182 (23%)
		WWE	1379..1446	CDD:460715	28/69 (41%)
		DDHD	1754..1981	CDD:460725	103/229 (45%)
SEC23IP	NP_009121.1	Interaction with SEC23A. /evidence=ECO:0000269|PubMed:10400679	1..367		122/488 (25%)
		PRK10263	<43..>310	CDD:236669	87/393 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	133..252		38/221 (17%)
		SAM_sec23ip	638..702	CDD:188983	3/63 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	716..748		9/31 (29%)
		DDHD	779..988	CDD:460725	103/229 (45%)