Protein Alignment Trf and TBP

DIOPT Version :10

• Sequence 1: NP_476939.1
• Gene: Trf / 34102
• FlyBaseID: FBgn0010287
• Length: 224
• Species: Drosophila melanogaster
• Sequence 2: NP_003185.1
• Gene: TBP / 6908
• HGNCID: 11588
• Length: 339
• Species: Homo sapiens
• Alignment Length: 196
• Identity: 113/196 - (57%)
• Similarity: 148/196 - (75%)
• Gaps: 2/196 - (1%)

  Fly    31 LQPQQPVALVEPKDAQHEI--RLQNIVATFSVNCELDLKAINSRTRNSEYSPKRFRGVIMRMHSP 93
            :.|..|:....|......|  :|||||:|.::.|:||||.|..|.||:||:||||..||||:..|
Human   143 MTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREP 207

  Fly    94 RCTALIFRTGKVICTGARNEIEADIGSRKFARILQKLGFPVKFMEYKLQNIVATVDLRFPIRLEN 158
            |.|||||.:||::||||::|.::.:.:||:||::||||||.||:::|:||:|.:.|::||||||.
Human   208 RTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEG 272

  Fly   159 LNHVHGQFSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRKDIMDCLEAISPILLSFRK 223
            |...|.||||||||:||||||||:||||||||||:||||.||||.|.:|.:..|.|.|||..|||
Human   273 LVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRK 337

  Fly   224 T 224
            |
Human   338 T 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trf	NP_476939.1	TBP_eukaryotes	50..221	CDD:239952	105/170 (62%)
TBP	NP_003185.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		polyglutamine repeat	58..95
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..159		3/15 (20%)
		PLN00062	162..338	CDD:177693	107/175 (61%)
		Repetitive region	165..241		43/75 (57%)
		Repetitive region	255..332		51/76 (67%)