DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trf and tlf-1

DIOPT Version :9

Sequence 1:	NP_476939.1	Gene:	Trf / 34102	FlyBaseID:	FBgn0010287	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_001122474.1	Gene:	tlf-1 / 172676	WormBaseID:	WBGene00006577	Length:	508	Species:	Caenorhabditis elegans

Alignment Length:	212	Identity:	66/212 - (31%)
Similarity:	113/212 - (53%)	Gaps:	18/212 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NVAATSNAAANPHAALQPQQPVALVEPKDAQHEIRLQNIVATFSVNCELDLKAINSRTRNSEYSP 80
            :|.....:|||       ::|:    |.|...:|:::|:|..:::...:||:.:...|.|..|
Worm   246 DVPPEGTSAAN-------EEPM----PDDGDIDIQIRNVVCNYTLPLHIDLRKLAMNTHNVTY-- 297

  Fly    81 KRFRGVIMRM-HSPRCTALIFRTGKVICTGARNEIEADIGSRKFA----RILQKLGFPVKFMEYK 140
            :|.:||:|:. .||.|...::.:|||...|.|:|.:....:|..|    |::.|....|....|:
Worm   298 EREKGVMMKQKRSPGCYIKVYSSGKVYIVGCRSEADCKRAARSIARHVQRVMGKTKERVSIRNYR 362

  Fly   141 LQNIVATVDLRFPIRLENLNHVHGQFSSYEPEMFPGLIYRMVKPRIVLLIFVNGKVVFTGAKSRK 205
            :.|::||..|.|.|::|.:...:...|:||||:..||::|.|.|:..|.|...|.:..|||:|..
Worm   363 VNNVLATCRLPFGIKIEEVAAKYPSESTYEPELSVGLVWRSVTPKATLRIHTTGSITVTGAQSEA 427

  Fly   206 DIMDCLEAISPILLSFR 222
            |:::.|..|.||:|.||
Worm   428 DVLEVLSKIYPIVLEFR 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf	NP_476939.1	PLN00062	49..224	CDD:177693	59/179 (33%)
Trf	NP_476939.1	TBP_eukaryotes	50..221	CDD:239952	56/175 (32%)
tlf-1	NP_001122474.1	Med15	<3..>218	CDD:312941
		KLF1_2_4_N	<183..217	CDD:425360
		TLF	266..442	CDD:239953	56/177 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910