Protein Alignment Megf8 and ATRN

DIOPT Version :10

• Sequence 1: NP_609180.3
• Gene: Megf8 / 34099
• FlyBaseID: FBgn0031981
• Length: 2892
• Species: Drosophila melanogaster
• Sequence 2: NP_647537.1
• Gene: ATRN / 8455
• HGNCID: 885
• Length: 1429
• Species: Homo sapiens
• Alignment Length: 1827
• Identity: 376/1827 - (20%)
• Similarity: 567/1827 - (31%)
• Gaps: 750/1827 - (41%)

  Fly  1280 SEGEKCERCRQGSYGNATAPHGCLPCECNGHGNQDLGVCNVSNGECYCKDNTQGLNCELCAPGYY 1344
            :|.::|:|                || .||      |.||...|:|.|.....|..|:.|
Human    96 AEAKECDR----------------PC-VNG------GRCNPGTGQCVCPAGWVGEQCQHC----- 132

  Fly  1345 GDPRGGGKCYYQCESRGILTNIGKSAIGSYQSYRSPWGASLEVKECLWIL--QPKTLQAEKSLLQ 1407
                 ||: :....|.|.:|:    ..|:|: |::         :|.|::  ||..:
Human   133 -----GGR-FRLTGSSGFVTD----GPGNYK-YKT---------KCTWLIEGQPNRI-------- 169

  Fly  1408 LEFQWQSLAMDCDENAVYIYDSLPDLTGATQQNQLLAVVCAPYSS------------PRIIEARS 1460
            :..::...|.:|..:.:|:||.          :.:.|.:.|.:|.            |.:: |.|
Human   170 MRLRFNHFATECSWDHLYVYDG----------DSIYAPLVAAFSGLIVPERDGNETVPEVV-ATS 223

  Fly  1461 SHVTVHYKQGSERRHFGFNALYSV----MNCVA-GSCISPHICDAQQRCVCPAGYVGASCEIEIC 1520
            .:..:|:...:.....|||..||.    .||.. |.|...:..|..: |.|...:.|.:|:|..|
Human   224 GYALLHFFSDAAYNLTGFNITYSFDMCPNNCSGRGECKISNSSDTVE-CECSENWKGEACDIPHC 287

  Fly  1521 PSNCNAKRMQGFCDTEYGR-CICSNANYAGADCGTLVQRNHLVMTELFNTQLLSESLEHLRKTIP 1584
            ..||.... :|.|::...| |.|. :::.|..|...|..|....|.        |...:|:  :|
Human   288 TDNCGFPH-RGICNSSDVRGCSCF-SDWQGPGCSVPVPANQSFWTR--------EEYSNLK--LP 340

  Fly  1585 RFGHS--VNADRRGSLWMFGGYSPNHGPLNDFRQFDTKNSTWLQVTVESSTPEDRMPLG------ 1641
            |..|.  ||.:   .:|:.|||..||...|....:|..:..||             ||.
Human   341 RASHKAVVNGN---IMWVVGGYMFNHSDYNMVLAYDLASREWL-------------PLNRSVNNV 389

  Fly  1642 --RYFHASEIYVKKQIIYIYGG-IGANSQLLNDFWMFSIQNQRWSQIKVEVEPPEADYEVDVPPP 1703
              ||.|:..:|  |..||:||| |.:...:.|:..:|.|.|:.|..:     .|:|..:..|
Human   390 VVRYGHSLALY--KDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLL-----TPKAKEQYAV--- 444

  Fly  1704 LAGHTLTHIRYQEHESLILL---------GGLSLNKSRPLELWEFNLDTGRWQQLAAVGARMPVL 1759
             .||: .||...::..:::|         |.:|       .:.|::||...|..|...||.:...
Human   445 -VGHS-AHIVTLKNGRVVMLVIFGHCPLYGYIS-------NVQEYDLDKNTWSILHTQGALVQGG 500

  Fly  1760 YGHTSVYHQETNSVYLFGGYST------EPQSNLYALDLQKLSWTELPSFRELNSPASLLPRARY 1818
            |||:|||...|.::|:.|||..      ....:||..|:....||.|...|..          ||
Human   501 YGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTILKDSRFF----------RY 555

  Fly  1819 FHSAVTTEHYMILYGGRTQPFNGTDV----------LIAYVYACNQW-----VRLTEDVELIGRV 1868
            .|:||.....|:::||.|.  |.|.:          .:||..||::|     ..|..||...|.
Human   556 LHTAVIVSGTMLVFGGNTH--NDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLHHDVNRFGH- 617

  Fly  1869 PASSYAEDMAIDPDTGAIYVIGGWDG--------------SSTHSHVTKITLPDDICQLWSNGKY 1919
              |:...:       ..:||.||::.              .:..|....:.....|..:|:.|..
Human   618 --SAVLHN-------STMYVFGGFNSLLLSDILVFTSEQCDAHRSEAACLAAGPGIRCVWNTGSS 673

  Fly  1920 QCRHYMGCSYCTIQNTYSYSSHCFSHGRTPCANHNGTLVVNNGAACDDDWMASRNCSSFATCGAC 1984
            ||   :..:..|.:......|.|||. ||                .|.|     .|.....|.:|
Human   674 QC---ISWALATDEQEEKLKSECFSK-RT----------------LDHD-----RCDQHTDCYSC 713

  Fly  1985 LAAWPTHQEVAPVCHWCDDCGIRGRCVPAGVDCGRRSAWCNKELSVGVLGLCPL--PQCY---QL 2044
            .|  .|:.     ||||:|     .|||....|.      ..::|:.....||.  |..|   :.
Human   714 TA--NTND-----CHWCND-----HCVPRNHSCS------EGQISIFRYENCPKDNPMYYCNKKT 760

  Fly  2045 SCESCMLQPQCNW-ARNELGTVECI-----------------------AKELVEK---------- 2075
            ||.||.|...|.| .||:    |||                       |||..:.
Human   761 SCRSCALDQNCQWEPRNQ----ECIALPENICGIGWHLVGNSCLKITTAKENYDNAKLFCRNHNA 821

  Fly  2076 ---------------NQYRVVES------------------------------------------ 2083
                           .|.|:::|
Human   822 LLASLTTQKKVEFVLKQLRIMQSSQSMSKLTLTPWVGLRKINVSYWCWEDMSPFTNSLLQWMPSE 886

  Fly  2084 ------------------------------------------CPLPCHTYENCSLCLSQTPTQDH 2106
                                                      |..||.....|..|     |...
Human   887 PSDAGFCGILSEPSTRGLKAATCINPLNGSVCERPANHSAKQCRTPCALRTACGDC-----TSGS 946

  Fly  2107 QECKWSTMLNLCLTPSSQPLLCAGGVCGLVLEASELQRC-PEPCHVYTQCSSCLEHAHCGWCARE 2170
            .||.|.:.:..|:..::.......|.|   :|...:..| ||.|..|..||.|||...||||...
Human   947 SECMWCSNMKQCVDSNAYVASFPFGQC---MEWYTMSTCPPENCSGYCTCSHCLEQPGCGWCTDP 1008

  Fly  2171 GFNGDGICTEGALEHKQEHPSGSTCDLIYAS-WRNDSQLTHADVVSWHYVQCPAENECINGHHNC 2234
            ...|.|.|.||:.:...:.||.:.....|.. ..|.|........:|.::.|||
Human  1009 SNTGKGKCIEGSYKGPVKMPSQAPTGNFYPQPLLNSSMCLEDSRYNWSFIHCPA----------- 1062

  Fly  2235 DTVSEQCIDLDTAVGYKCVCAQGYREEQGACLPVCSQGCVRGNCVSPDQCQCDFGYVGANCSIQC 2299
                                                                            |
Human  1063 ----------------------------------------------------------------C 1063

  Fly  2300 LCNGHSNCESSSRLDICLKCHNNTMGEQCEKCQPLFVGNPREGHACQPCLDYCHGHSDVCVAYDA 2364
            .|||||.|.:.|   ||.||.|.|.|:.||.|...|.|:|..|..||
Human  1064 QCNGHSKCINQS---ICEKCENLTTGKHCETCISGFYGDPTNGGKCQ------------------ 1107

  Fly  2365 DPAVFNMTRSELERILQEGPAYNATCLRCGNHTAGDRCDSCLTGYFRGSEDLHKECRPCQCHGHG 2429
                                                                     ||:|:||.
Human  1108 ---------------------------------------------------------PCKCNGHA 1115

  Fly  2430 NICDPVTGEKCNCANNTESDATCTAGGGKNSAQLCWMVQCSKCRDSYAGNPTDGHQCYKQITVES 2494
            ::|:..|| ||.|.         |.|...:..|||      :..:.|.|||..| .||..:.::.
Human  1116 SLCNTNTG-KCFCT---------TKGVKGDECQLC------EVENRYQGNPLRG-TCYYTLLIDY 1163

  Fly  2495 RMCFDAKPIEECKSKPAALKPGQTVFFVIQPRFMNVDIRIIIDVTQG-ELDVFMSPQ-------- 2550
            :..|.....::        :....:.||..|...|.|:.:.|:.::. .|::..:..
Human  1164 QFTFSLSQEDD--------RYYTAINFVATPDEQNRDLDMFINASKNFNLNITWAASFSAGTQAG 1220

  Fly  2551 DDSFIVETNETTGYHEIFLDNRYNWGPKIKREHPLNVALPRHDNVTIQKLFSPERRIGGGGLGGG 2615
            ::..:|.......|.:.|.:.::::     |.||         |:|
Human  1221 EEMPVVSKTNIKEYKDSFSNEKFDF-----RNHP---------NIT------------------- 1252

  Fly  2616 GGERIGANTYYVPQLQDCKSHGGHNFIVKDQHAKDLSTHVTLNHCNTLLRLFGLKNRLVLTLPQH 2680
                                                                             
Human  1253 ----------------------------------------------------------------- 1252

  Fly  2681 AHNLSATRFFIALRASSGPEPSYGSVVFRQDQLHIDLFVFFSVFFSCFFLFLAVCVIVWKVKQAA 2745
                    ||:.:  |:...|....:.|.|....:||..||..|||||...|.|..:|||:||:.
Human  1253 --------FFVYV--SNFTWPIKIQIAFSQHSNFMDLVQFFVTFFSCFLSLLLVAAVVWKIKQSC 1307

  Fly  2746 DLRRARRQHVVEMLHLAKRPFAQIFLASNGLDMDSPQPTSSSSSARAMRQRARQALLLQEQSAGD 2810
            ...|.|.|.:.||..:|.||||.:.:|   |:.|...|.....|.:.:.:
Human  1308 WASRRREQLLREMQQMASRPFASVNVA---LETDEEPPDLIGGSIKTVPK--------------- 1354

  Fly  2811 SQSVMHHSTRRQSSRIMMVAIEPTFDNLAAVGTVFISL---------PGRSRAPLSIALGSTLIS 2866
                             .:|:||.|.|.|||.:||:.|         ||:|    .:|:.|.|:.
Human  1355 -----------------PIALEPCFGNKAAVLSVFVRLPRGLGGIPPPGQS----GLAVASALVD 1398

  Fly  2867 YSRQYPL 2873
            .|:|.|:
Human  1399 ISQQMPI 1405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Megf8	NP_609180.3	CUB	33..141	CDD:238001
		NanM	<210..455	CDD:442289
		KELCH repeat	228..268	CDD:276965
		KELCH repeat	370..420	CDD:276965
		KELCH repeat	425..476	CDD:276965
		NanM	431..>630	CDD:442289
		KELCH repeat	480..540	CDD:276965
		EGF_3	1186..1222	CDD:463759
		EGF_Lam	1257..1302	CDD:238012	3/21 (14%)
		EGF_Lam	1304..1354	CDD:238012	15/49 (31%)
		KELCH repeat	1585..1638	CDD:276965	14/54 (26%)
		NanM	1596..1892	CDD:442289	87/334 (26%)
		KELCH repeat	1642..1685	CDD:276965	16/43 (37%)
		KELCH repeat	1760..1813	CDD:276965	18/58 (31%)
		KELCH repeat	1817..1867	CDD:276965	19/64 (30%)
		EGF_Lam	2299..2346	CDD:238012	22/46 (48%)
		EGF_Lam	2422..2487	CDD:238012	21/64 (33%)
ATRN	NP_647537.1	CUB	132..247	CDD:238001	29/158 (18%)
		NanM	329..634	CDD:442289	96/371 (26%)
		KELCH repeat	341..382	CDD:276965	14/56 (25%)
		KELCH repeat	392..441	CDD:276965	18/55 (33%)
		KELCH repeat	448..496	CDD:276965	11/55 (20%)
		KELCH repeat	501..550	CDD:276965	17/48 (35%)
		KELCH repeat	554..609	CDD:276965	16/56 (29%)
		CLECT_attractin_like	788..920	CDD:153067	6/131 (5%)
		PSI	932..983	CDD:396154	12/58 (21%)
		EGF_Lam	1062..1107	CDD:238012	23/122 (19%)
		EGF_Lam	1108..1153	CDD:238012	20/60 (33%)