DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Megf8 and trol

DIOPT Version :10

Sequence 1:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster
Sequence 2:NP_001401049.1 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4489 Species:Drosophila melanogaster


Alignment Length:2174 Identity:427/2174 - (19%)
Similarity:635/2174 - (29%) Gaps:831/2174 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   643 ENTLYNPEISCRLHSSHTACLSNPECGWCSADSSCYGRTIGANCTTNLQT----TRCPGI--CPS 701
            |..:|.|.......:|...|.||.                 ..|||:...    .||.|.  |..
  Fly   685 EYQVYQPSNVYEKANSQNPCASNQ-----------------FRCTTSNVCIPLHLRCDGFYHCND 732

  Fly   702 LGDCHSCLVHGSQWGKSSGNKAAFSVASKL--------GLNECTWCVQNAKCHHRDDNYGICGDS 758
            :.|..||    .|:.:.:..:...::|:..        ||.|             ..|.....::
  Fly   733 MSDEKSC----EQYQRHTTTRRPLTLATPTSRITTQGPGLLE-------------RRNTTTATEA 780

  Fly   759 SGW-WGDKGTEIRRPSLCTSTDRRPGLTYIKYHFPINYTMPDYVGIVNATMVDFASPPFTTYFEH 822
            |.| |..|.|.|      .:|...|..|               ||:.|       |||.|.    
  Fly   781 SRWPWATKTTTI------ATTTSNPITT---------------VGVAN-------SPPQTC---- 813

  Fly   823 KLEGEMLARLVGFVRPQHQWNNSAIQ-VCTSYSSAVLRAGLGLNLDELVNVTTQSSNQSYCSNVQ 886
             ||....|        .|..:..:|: ||......      |.|.||...:...|.::..|    
  Fly   814 -LENIEFA--------CHNRDCISIESVCDGIPDC------GRNEDEDDALCKCSGDKYKC---- 859

  Fly   887 LPTTEQPFTIDFQTRRRIGG--------NGIYNAYQKTKMELQHLHNGQLN--AFTFEYLEPYY- 940
                           :|.||        :|....:.::.....||| |:||  ....:.||..| 
  Fly   860 ---------------QRGGGCIPKSQVCDGKPQCHDRSDESACHLH-GRLNKTRLGVKCLESQYQ 908

  Fly   941 --SGKC-TQYSNC--LHCLTDAS----CAW--------CPLTNICHLRSVNETEVCKMETLDTFH 988
              .|.| :.|..|  :|...|||    |.:        .|..|     .:||.::.:      |.
  Fly   909 CGDGSCISGYKRCNGIHDCADASDEYNCIYDYEDTYDTDPNNN-----PLNECDILE------FE 962

  Fly   989 WSYLISQPSQC----SNCTNYVSCEACARSGECEWWTEDARCGRIGKTNSSVRAVEHC-PRS--C 1046
            ..|     |||    ..|..|..||..:...||:.:|:  .|     ..|......:| ||.  |
  Fly   963 CDY-----SQCLPLEKKCDGYADCEDMSDELECQSYTD--HC-----LESEFECDSYCLPRDQLC 1015

  Fly  1047 RERHGCQECLGERGRCVWCEASAQCFSFSVYTSEYQFGMCREWVDQVVSRQTQEIADHKPQQTPH 1111
            .....||:...|| .|.:|...|.              :|........:::...|||        
  Fly  1016 NGIPNCQDGSDER-NCTFCREDAY--------------LCNTGECVADNQRCNGIAD-------- 1057

  Fly  1112 FLQQQCKSCEQHRNCSSCL---RTLSC-GWCFDRDNPIEGI--CMQGDFSYSAGNCSLALNSSSH 1170
                 |......|:|:...   ..|:| |.|..|....:||  |:.|   |....|.   .:::|
  Fly  1058 -----CADGSDERHCARIYCPPNKLACNGTCVSRRIKCDGIRDCLDG---YDEMYCP---ETNNH 1111

  Fly  1171 HDA----------------------EWAYA---------QCPDVDECGLG----LHDCH------ 1194
            :..                      ||..|         ||.::.:|..|    |..|.      
  Fly  1112 YPTQNVNVIRPKLGPNPIPKSCRPHEWQCANLECIDSSLQCNEIKDCSDGSDEELSVCFGTATTR 1176

  Fly  1195 -KEAKCTNTQGSYNCHCRRGYIGDGKFSCVRTCYELCQNGNCSGPPDYTCRCALGWTGADCGLSC 1258
             |.:.|:..|                |.|..:||.  ::..|:|..|    |:.|.....|.|.|
  Fly  1177 LKPSDCSPEQ----------------FYCDESCYN--RSVRCNGHVD----CSDGSDEVGCSLPC 1219

  Fly  1259 ---GCNNHSTCNERLGKCDQ---CQDWSEGEKCERCRQGSYGNATAPHGCLPC----ECNGH--- 1310
               .|.: ..|.....:||:   |:|.|:...|....|....|.....|..||    ||:.|   
  Fly  1220 PQHQCPS-GRCYTESERCDRHRHCEDGSDEANCCYANQFRCNNGDCVSGSAPCNGYSECSDHSDE 1283

  Fly  1311 ----GNQDL---------GVCNVS----NGECYCKDNTQGLNCELCA----PGY-----YGD--- 1346
                |.|:.         |.|..|    ||...|:|::...||...:    |..     |.|   
  Fly  1284 LNCGGTQECLPNQFRCNSGQCVSSSVRCNGRTDCQDSSDEQNCAADSNDRRPNQLNLKTYPDSQI 1348

  Fly  1347 -----------------------PRGGGKCY-----------------------YQCESRG---- 1361
                                   .|.||:..                       |.||:.|    
  Fly  1349 IKESREVIFRCRDEGPARAKVKWSRPGGRPLPPGFTDRNGRLEIPNIRVEDAGTYVCEAVGYASY 1413

  Fly  1362 -----ILTNIG-----------KSAIGSYQSYRSPWGASLEVKECLWILQPKTLQAEKSLLQLEF 1410
                 :..|:.           :||...||       |:....||:          :||.:    
  Fly  1414 IPGQQVTVNLNVERYNDVGSRPESACTEYQ-------ATCMNGECI----------DKSSI---- 1457

  Fly  1411 QWQSLAMDCDENAVYIYDSLPDLTGAT-QQNQLLAVVCAPYSSPRIIEARSSHVTVHYKQGSER- 1473
                    ||.|        ||.:.|: :|:..|.:.|.|   .:.:.:.|..|...::...|. 
  Fly  1458 --------CDGN--------PDCSDASDEQSCSLGLKCQP---NQFMCSNSKCVDRTWRCDGEND 1503

  Fly  1474 ------------RHFGFNALYSVMNCVAGSCISPHI-CDAQQRCVCPAGYVGASCEIEICPSNCN 1525
                        ...|....|:...|.:|.||.... ||....|......||....:.|.|.   
  Fly  1504 CGDNSDETSCDPEPSGAPCRYNEFQCRSGHCIPKSFQCDNVPDCTDGTDEVGCMAPLPIRPP--- 1565

  Fly  1526 AKRMQGFCDTEYG----RCI---------------------CSNANYAGADCGTL------VQRN 1559
               .|.....||.    .|:                     |.:.:|.|.  |||      .|.:
  Fly  1566 ---PQSVSLLEYEVLELTCVATGTPTPTIVWRLNWGHVPDKCESKSYGGT--GTLRCPDMRPQDS 1625

  Fly  1560 HLVMTELFNTQLLSESLEHLRKTIPRFGHSVNADRRGSLWMFGGYSPNHGPLNDFRQFDTKNSTW 1624
            .....|:.||               |..|.||.|                               
  Fly  1626 GAYSCEIINT---------------RGTHFVNPD------------------------------- 1644

  Fly  1625 LQVTVESSTP--EDRMPLGRYFHASEIYVKKQIIYIYGGIGANSQLLNDFWMFSIQNQRWSQIKV 1687
               |:.:..|  .|....| :|:......::.:.....|:.......|.|               
  Fly  1645 ---TIVTVRPVRTDVCEAG-FFNMLARKAEECVQCFCFGVAKACDSANLF--------------- 1690

  Fly  1688 EVEPPEADYEVDVPPPLAGHTLTHIRYQEHESLILLGGLSLNKSRPLELWEFNLDTGRWQQLAAV 1752
                   .|.:.  ||:..|.:..:.......::      :|::.|            .|.|   
  Fly  1691 -------TYAIH--PPILSHRVVSVELSPLRQIV------INEAAP------------GQDL--- 1725

  Fly  1753 GARMPVLYG----HTSVYHQETNSVYL-------------FGGYSTEPQSNL-YALDLQKLSWTE 1799
               :.:|:|    .|:|:.....:.||             :||       || |.::.:      
  Fly  1726 ---LTLLHGVQFRATNVHFSGRETPYLALPADYMGNQLKSYGG-------NLRYEVNYR------ 1774

  Fly  1800 LPSFRELNSPASLLPRARYFHSAVTTEHYMILYGGRTQPFNGTDVLIAYVYACNQWVRLTEDVEL 1864
             .|.|.:|.|..:          :|...:.:.|..||||.....|.|.:|  ...|.:..     
  Fly  1775 -GSGRPVNGPDVI----------ITGNRFTLTYRVRTQPGQNNRVSIPFV--PGGWQKPD----- 1821

  Fly  1865 IGRVPASSYAEDMAIDPDTGAIYV-IGGWDGSSTHSHVTKITLPDDICQLWSNG--------KYQ 1920
             ||  .:|..|.|.|..:...|.: :|..|  ||...|..|.:..|.......|        |.|
  Fly  1822 -GR--KASREEIMMILANVDNILIRLGYLD--STAREVDLINIALDSAGTADKGLGSASLVEKCQ 1881

  Fly  1921 C-RHYMG--CSYCTI----QNTYSYSSHC--FSHGRTPCANHNGTLVVNNGAACDDDWMASRNCS 1976
            | ..|:|  |..|..    |....:..||  |.....|...:...   ..|..|.:........:
  Fly  1882 CPPGYVGDSCESCASGYVRQPGGPWLGHCVPFIPDSCPSGTYGDP---RRGVPCKECPCPLTGSN 1943

  Fly  1977 SFATCGACLAAWPTHQEVAP----VCHW--------CDDC--GIRGRCVPAGVDCGR-RSAWCNK 2026
            :||:  .|        :.:|    ||..        |:.|  |.:|..:.||..|.| ....||.
  Fly  1944 NFAS--GC--------QQSPDGDVVCRCNEGYTGRRCEQCAAGYQGNPLAAGGICRRIPDTSCNV 1998

  Fly  2027 E--LSVGVLGLCPLPQCYQLSCESCMLQPQCNWARNELGTVECIAKELVEKNQYRVVESCPLPCH 2089
            :  .||...|.|        .|:..::..||:..::                     :|..|...
  Fly  1999 DGTYSVHSNGTC--------QCKDSVIGEQCDTCKS---------------------KSFHLNSF 2034

  Fly  2090 TYENCSLCLSQTPTQDHQECKW------STMLNLCLTPSSQPLLCAGGVCGLVLEASELQRCPEP 2148
            ||..|..|.......|.....|      ||.....:..            |.||..:.:|..|:.
  Fly  2035 TYTGCIECFCSGVGLDCDSSTWYRDQVTSTFGRSRVDH------------GFVLVTNYMQPTPDT 2087

  Fly  2149 CHV--------------YTQCSSCLEHAHCGWCAREGFNGDGICTEGA-LEHKQEH---PSG--- 2192
            ..|              ..|..:.|.     |.....|.|:.:.:.|. |.:...:   |:|   
  Fly  2088 VPVSMAAEPNALSFIGSADQSGNTLY-----WSLPAAFLGNKLSSYGGKLTYTLSYSPLPNGIMS 2147

  Fly  2193 --STCDLIYASWRNDSQLTH-------ADVVSWHYVQCP------AENECINGHHNCDTVSEQCI 2242
              |..|::..| ..|.:|.|       ..|.:.:.|:..      .:....|..|....:|:   
  Fly  2148 RNSAPDVVIKS-GEDLRLIHYRKSQVVPSVANTYSVEIKESAWQRGDEVVANREHVLMALSD--- 2208

  Fly  2243 DLDTAVGYKCVCAQGYREE--QGACLPVCSQ---GCVRGNCVSPDQCQCDFGYVGANCSIQCL-- 2300
              .||:..|.......:|.  :...|.|.:.   |..|  .|..:||:|..||:|.:|. ||.  
  Fly  2209 --ITAIYIKATYTTSTKEASLRQVTLDVATPTNLGTPR--AVEVEQCRCPEGYLGLSCE-QCAPG 2268

  Fly  2301 ------------------CNGHSNCESSSRLDICLKCHNNTMGEQCEKCQPLFVGNPREG--HAC 2345
                              |||||...:|...| |.:|.:||.|..||:|...:||:...|  :.|
  Fly  2269 YARDPEGGIYLGLCRPCECNGHSKYCNSDTGD-CEECSDNTEGPSCERCAAGYVGDATRGTIYDC 2332

  Fly  2346 QPCLDY------CHGHSDV-CVAYDADPAVFNMTRSELERILQEGPAYNATCLRCGNHTAGDRCD 2403
            ||...|      ..|:..: |.||.....:::...:|              || |..:..||:||
  Fly  2333 QPDEGYPIPSPPAPGNQTLECTAYCQIEGIYDCRGNE--------------CL-CKRNVIGDQCD 2382

  Fly  2404 SCLTGYFRGSEDLHKECRPCQCHGHGNIC 2432
            .|..|.:..|......|:.|.|.|..:.|
  Fly  2383 QCRPGTYGLSAQNQDGCKECYCSGLASQC 2411

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Megf8NP_609180.3 CUB 33..141 CDD:238001
NanM <210..455 CDD:442289
KELCH repeat 228..268 CDD:276965
KELCH repeat 370..420 CDD:276965
KELCH repeat 425..476 CDD:276965
NanM 431..>630 CDD:442289
KELCH repeat 480..540 CDD:276965
EGF_3 1186..1222 CDD:463759 8/46 (17%)
EGF_Lam 1257..1302 CDD:238012 11/50 (22%)
EGF_Lam 1304..1354 CDD:238012 22/108 (20%)
KELCH repeat 1585..1638 CDD:276965 8/54 (15%)
NanM 1596..1892 CDD:442289 49/316 (16%)
KELCH repeat 1642..1685 CDD:276965 4/42 (10%)
KELCH repeat 1760..1813 CDD:276965 14/70 (20%)
KELCH repeat 1817..1867 CDD:276965 10/49 (20%)
EGF_Lam 2299..2346 CDD:238012 19/68 (28%)
EGF_Lam 2422..2487 CDD:238012 4/11 (36%)
trolNP_001401049.1 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060 11/51 (22%)
LDLa 813..847 CDD:238060 11/52 (21%)
LDLa 852..887 CDD:238060 6/53 (11%)
LDLa 902..936 CDD:238060 11/33 (33%)
LDLa 956..990 CDD:238060 9/44 (20%)
LDLa 997..1030 CDD:238060 10/38 (26%)
LDLa 1033..1067 CDD:238060 8/60 (13%)
LDLa 1072..1105 CDD:238060 10/35 (29%)
LDLa 1133..1165 CDD:238060 7/31 (23%)
LDLa 1182..1215 CDD:238060 11/54 (20%)
LDLa 1221..1251 CDD:238060 7/30 (23%)
LDLa 1252..1286 CDD:238060 8/33 (24%)
LDLa 1292..1326 CDD:238060 7/33 (21%)
Ig 1344..1405 CDD:472250 5/60 (8%)
Ig strand B 1355..1359 CDD:409353 0/3 (0%)
Ig strand C 1369..1372 CDD:409353 0/2 (0%)
Ig strand E 1388..1392 CDD:409353 0/3 (0%)
LDLa 1439..1473 CDD:238060 14/70 (20%)
LDLa 1479..1513 CDD:238060 5/36 (14%)
LDLa 1522..1556 CDD:238060 9/33 (27%)
Ig_Perlecan_like 1574..1649 CDD:143220 18/125 (14%)
Ig strand B 1577..1583 CDD:143220 1/5 (20%)
Ig strand C 1590..1595 CDD:143220 0/4 (0%)
Ig strand E 1613..1617 CDD:143220 3/3 (100%)
Ig strand F 1626..1632 CDD:143220 0/5 (0%)
Ig strand G 1641..1647 CDD:143220 4/39 (10%)
Laminin_B 1748..1878 CDD:459652 36/165 (22%)
EGF_Lam 1935..1989 CDD:238012 12/63 (19%)
Laminin_B 2113..2249 CDD:459652 27/148 (18%)
EGF_Lam <2250..2276 CDD:238012 9/26 (35%)
EGF_Lam 2284..2333 CDD:238012 18/49 (37%)
Laminin_EGF <2369..2399 CDD:395007 11/44 (25%)
Laminin_B 2465..2599 CDD:459652
Ig_3 2688..2756 CDD:464046
Ig_3 2791..2861 CDD:464046
Ig_3 2890..2958 CDD:464046
Ig 2987..3071 CDD:472250
Ig strand B 3004..3008 CDD:409353
Ig strand C 3017..3021 CDD:409353
Ig strand E 3036..3040 CDD:409353
Ig strand F 3050..3055 CDD:409353
Ig strand G 3063..3066 CDD:409353
I-set 3089..3162 CDD:400151
Ig strand B 3094..3098 CDD:409353
Ig strand C 3107..3111 CDD:409353
Ig strand E 3128..3132 CDD:409353
Ig strand F 3142..3147 CDD:409353
Ig strand G 3155..3158 CDD:409353
Ig 3165..3253 CDD:472250
Ig strand B 3185..3189 CDD:409353
Ig strand C 3198..3202 CDD:409353
Ig strand E 3219..3223 CDD:409353
Ig strand F 3233..3238 CDD:409353
Ig strand G 3246..3249 CDD:409353
Ig 3298..3355 CDD:472250
Ig strand B 3301..3305 CDD:409353
Ig strand C 3313..3316 CDD:409353
Ig strand E 3333..3336 CDD:409353
IG_like 3381..3457 CDD:214653
Ig strand B 3390..3394 CDD:409353
Ig strand C 3403..3407 CDD:409353
Ig strand F 3437..3442 CDD:409353
IG_like 3475..>3536 CDD:214653
Ig strand B 3480..3484 CDD:409353
Ig strand C 3491..3503 CDD:409353
Ig strand E 3519..3523 CDD:409353
Ig 3613..3675 CDD:472250
Ig strand B 3625..3629 CDD:409353
Ig strand C 3637..3642 CDD:409353
Ig strand E 3658..3662 CDD:409353
IG_like 3706..3772 CDD:214653
Ig strand B 3714..3718 CDD:409353
Ig strand C 3727..3731 CDD:409353
Ig strand E 3746..3750 CDD:409353
Ig strand F 3760..3765 CDD:409353
Ig strand G 3774..3777 CDD:409353
LamG 3794..3939 CDD:238058
EGF 3962..3994 CDD:394967
LamG 4042..4195 CDD:238058
EGF_CA 4254..4286 CDD:238011
LamG 4295..4448 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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