DRSC/TRiP Functional Genomics Resources

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Protein Alignment Megf8 and wb

DIOPT Version :10

Sequence 1:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster
Sequence 2:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster


Alignment Length:2273 Identity:406/2273 - (17%)
Similarity:599/2273 - (26%) Gaps:995/2273 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   612 RRNHTLLIVGGYHGNVNADLFAYELPQVLRVENTLYNP--------EISCRLHSSHTACLSNPEC 668
            |||..|...||..|.....|...|..........||.|        :||.           |..|
  Fly   119 RRNGKLQKSGGGAGGGALRLLKTEDVYSSSFSGGLYPPLFNVVPRAQISV-----------NATC 172

  Fly   669 GWCSADSSCYGRTIGANCTTNLQTTRCPGICPSLGDCHSCLVHGSQWGKSSGNKAAFSVASKLGL 733
            |...|:..|  :.:||.                  .|..|..|.|...|....::..|..|..|.
  Fly   173 GQNGAEEYC--KQVGAK------------------PCGICNAHSSDRAKQRSIQSLISSGSGSGS 217

  Fly   734 NECTWCVQNAKCHHRDDNYGICGDSSGWWGDKGTEIRRPSLCTSTDRRPGLTYIKYHFPINYTMP 798
            ..                    |...|||       :.|:|.....    ..|:.....:..|..
  Fly   218 GS--------------------GFEEGWW-------QSPTLQGGRQ----FEYVTILLDLKQTFQ 251

  Fly   799 DYVGIVNATMVDFASP-PFTTYFEHKLEGEMLARLVGFVRP-----------QHQWN-------- 843
                |.:..:....|| |.:...|..|:|      :.| .|           |.:||        
  Fly   252 ----IFSVWLKSANSPRPASWILEKSLDG------INF-EPWQYFGLSDADCQRRWNLSGQNGKY 305

  Fly   844 ---NSAIQVC-TSYS------SAVLRAGLGLNLDELVNVTTQSSNQSYCSNVQLPTTEQPFTIDF 898
               |....:| |.:|      :.||.|.|   |......|.||                |..:.|
  Fly   306 VFQNDTEIICSTQFSKPGPLENGVLHASL---LKNRPGATDQS----------------PELMKF 351

  Fly   899 QTRRRIGGNGIYNAYQKTKMELQHLHN--GQLNAFTFEYLEP------YYSGK---------CTQ 946
            .|.|.|            ::.||.:|:  .|.|:..:....|      :||..         |..
  Fly   352 ITTRYI------------RIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNG 404

  Fly   947 YSN--------------CLHCLTDASC-AWCPLTNICHLRSVNETEVCKME------TLDTFHWS 990
            ::|              |.|....|.| ..|||......:...|.|:|:..      |.|.|...
  Fly   405 HANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMGGECEICQCYGHAESCTYDPFLDK 469

  Fly   991 YLISQPSQCSNCTNYVSCEAC-----------------------ARS--------GECE------ 1018
            .:.   ..|||.|..:.||.|                       |||        |.|.      
  Fly   470 GIC---QSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARSTGGCQSDGGSCNCLEGFQ 531

  Fly  1019 ----------WWTEDA-RC-----GRIGKTNSSVRAVEHCPRSCR-----ERHGCQECL------ 1056
                      ::.:|. ||     |.:|.|.|       |...|:     |...|.||.      
  Fly   532 GKNCEECAPGYYGDDCKRCECDERGSLGSTGS-------CSGVCQCKLNVEGSTCSECAPGYFDL 589

  Fly  1057 ----GERGRCVWCEASAQ-CFSFSVYTSEYQFGMCREWVDQVVSRQTQEIADHKPQQTPHFLQQQ 1116
                .|.....||...:| |.|..:.|  ..|....:|       :..:|...||...|      
  Fly   590 SAENAEGCTSCWCSGVSQTCHSAKLQT--LAFETLNDW-------KITDIQRVKPISIP------ 639

  Fly  1117 CKSCEQHRNCSSCLRTLSCGWCFDRD-NPIEGICMQGDFSYSAGNCSLALNSSSHHDAEWAYAQ- 1179
             ...|.:|            ..|..: :.:|.|..|....| .||...:..|.......|...: 
  Fly   640 -VDAETNR------------LIFANELDEVEAIYWQASLGY-LGNRLTSYGSRLQLVLSWDVIRG 690

  Fly  1180 --------CPDV-------------DEC--GLGLHDCHKEAKCTNTQ-GSYN---------CHCR 1211
                    .|:|             ||.  |||::     ...|.|: |.|:         ...|
  Fly   691 DRSGKPTTGPNVILVGKNGLKIAFGDESLDGLGIN-----LNVTLTEVGWYHVPPTVVDIKTRLR 750

  Fly  1212 RGYIGD--------GKFSCV---------RTCYELCQN----------------GNCSGPPDYTC 1243
            |...||        .:|..|         |..:...|.                |..|......|
  Fly   751 RTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVELGGKSSSQVEQC 815

  Fly  1244 RCALGWTGADCG----------------------LSCGCNNHS-TCNERLGKCDQCQDWSEGEKC 1285
            .|..|:||..|.                      :.|.||.|| :|:.:.|.|..|...:.|::|
  Fly   816 LCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRC 880

  Fly  1286 ERCRQGSYGNAT--APHGCLPCEC---------------NGHGNQDLG-----------VCNVSN 1322
            |||:.|.|||..  .|:.|..|.|               ..:...||.           :|.   
  Fly   881 ERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICT--- 942

  Fly  1323 GECYCKDNTQGLNCELCAPGYYGDPRGGGKCYYQCESRGILTNIGKSAIGSYQSYRSPWGASLEV 1387
               .|.:...|.:|::|..||:|:||..|....:|:..|...|:......:.:.....|    ..
  Fly   943 ---QCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAGGPCNVTTGECITCRGNTEGW----HC 1000

  Fly  1388 KECLWILQPKTLQAEKSLLQLEFQWQSLAMDCDENAVYIYDSLPDLTGATQQNQLLAVVCAPYSS 1452
            :.|                :|.: |...|:.||.                         |     
  Fly  1001 ERC----------------KLGY-WGDPAVGCDP-------------------------C----- 1018

  Fly  1453 PRIIEARSSHVTVHYKQGSERRHFGFNALYSVMNCVAGSCISPHICDAQQRCVCPAGYVGASCE- 1516
                     |.   :.:|||                :|.|.|   .|.|  |:|...|.|..|: 
  Fly  1019 ---------HC---HTEGSE----------------SGLCDS---TDGQ--CLCKPRYAGQKCDE 1050

  Fly  1517 -------IEI-CPS-NCN--AKRMQGFCDTEYGRCICSNANYAGADCGTLVQRNHLVMTELFNTQ 1570
                   :|: ||| ||:  ...:|..||...|:|.|.. ...||.|       |......|...
  Fly  1051 CDVGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKE-GVMGAKC-------HECQDGYFGMN 1107

  Fly  1571 LLSESLEHLRKTIPRFGHSVNADRRGSLWMFGGYSPNHGPLNDFRQFDTKNSTWLQVTVESSTPE 1635
            .::..::.|.           |.|:.|                    |:.:..| ::..::..|.
  Fly  1108 AVAYRMDDLA-----------ALRQNS--------------------DSDDDEW-ELVPDTEDPN 1140

  Fly  1636 DRMPLG-RYFHASEIYVKKQIIYIYGGIGANSQLLNDFWMFSIQNQRWSQIKVEVEPPEADYEVD 1699
            ....:. ...|.|.:          |.:.::.            ::|..|...            
  Fly  1141 SESTVACEECHCSSV----------GSLSSDC------------DKRTGQCAC------------ 1171

  Fly  1700 VPPPLAGHTLTHIRYQEHESLILLGGLSLNKSRPLELWEFNLDTGRWQQLAAVGARMPVLYGHTS 1764
                ||..|                |...:|.||          |.|...|..|.|         
  Fly  1172 ----LANVT----------------GRRCDKCRP----------GHWNLTAGEGCR--------- 1197

  Fly  1765 VYHQETNSVYLFGGYSTEPQSNLYALDLQKLSWTELPSFRELNSPASLLPRARYFHSAVTTEHYM 1829
                                                                             
  Fly  1198 ----------------------------------------------------------------- 1197

  Fly  1830 ILYGGRTQPFNGTDVLIAYVYACNQWVRLTEDVELIGRVPASSYAEDMAIDPDTGAIYVIGGWDG 1894
                                                          |...||           .|
  Fly  1198 ----------------------------------------------DCRCDP-----------HG 1205

  Fly  1895 SSTHSHVTKITLPDDICQLWSNGKYQCRHYMG---CSYCTIQNTYSYS-------SHCFSHGRTP 1949
            |..|.           |..|: |:..|:..:|   |:.|| :..:.:|       |.|.|.|:. 
  Fly  1206 SRGHE-----------CNPWT-GQCDCKIGVGGQHCNECT-EGFFGFSTEGCQRCSACRSEGQV- 1256

  Fly  1950 CANHNGTLVVNNGAACDDDWMASRNCSSFAT---CGACL-AAWPTHQEVAPVCH--WCDDCGIRG 2008
            |..|||..:                |..|..   ||.|: ..|.....:.  |.  .||..|..|
  Fly  1257 CDPHNGRCI----------------CPKFTRGLGCGQCVPGTWGWQARLG--CRECECDHIGSIG 1303

  Fly  2009 -RCVPAGVDCGRRSAWCNKELSVGVLGLCPLPQCYQ----------------------------- 2043
             :|......|..|..:..::.....:|....|:|.:                             
  Fly  1304 QQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSL 1368

  Fly  2044 ---LSCESCMLQPQCNWARNELGTVECIA----------------KELVEKNQYRVVESCP--LP 2087
               |.|::||.......|:|..|...|..                ..:.|.....|.:..|  :|
  Fly  1369 VVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVP 1433

  Fly  2088 CHTYENCSLCLSQTPTQDHQECKWSTMLNLCLTPSSQPLLCAGGVCGLVLEASELQRCPEPCHVY 2152
            ...||...:...:..:...::.:...|.:|.|.|.|...:..|.. |........|..|:   .|
  Fly  1434 SSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAY-GQFYHPLYFQLPPQ---FY 1494

  Fly  2153 TQCSSCLEHAHCGWCAREGFNGDGICTEGALEHKQ-------EHP-------SGSTCDLI-YASW 2202
            ...:|          :..||....:.||||  ||.       ::|       |....|.. |..:
  Fly  1495 GDRTS----------SYGGFLYFTLITEGA--HKPLERNILGQYPLVQLHAHSKLLLDFYEYEEF 1547

  Fly  2203 RNDSQLTHADVVS---WHYVQCPAENECINGHHNCDTVSEQCIDLDTA------VGYKCVCAQGY 2258
            .....:||...:.   |.|            ||     :.|.:|.:|.      :.:..:.|..:
  Fly  1548 EYSLNVTHRVPLHESFWKY------------HH-----TSQAVDRNTLMAALQNIRHIFIRAFAF 1595

  Fly  2259 REEQGACL-------PVCSQGCVRGNCVSPDQCQCDFGYVGANC--------------------- 2295
            .:.|...|       .:..:|.........::|:|...:.|.:|                     
  Fly  1596 ADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFI 1660

  Fly  2296 ------SIQCLCNGH-SNCESSSRLDICLKCHNNTMGEQCEKCQPLFVGNPREGHACQ--PCLDY 2351
                  :..|.|||. |:|:..:  .:|..|..||.|:.|.:|...|.|:|...|.||  ||.:.
  Fly  1661 EDLIGRAAPCHCNGRSSDCDRET--GVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPET 1723

  Fly  2352 CHGHSDVCVAYDADPAVFNMTRSELERILQEGPAYNATCLRCGNHTAGDRCDSCLTGYFRGSEDL 2416
            ....:..|..:|.:                      .:|: |.....|..|:.|..|||  .:.:
  Fly  1724 NRNFARGCNVWDGE----------------------VSCV-CKPGYTGRLCERCQAGYF--GDPM 1763

  Fly  2417 ---HKECRPCQCHGHG---NICDPVTGEKCNCANNTESDATCTAGGGKNSAQLCWMVQCSKCR 2473
               :..|:||.||..|   ..||..|| :|.|......                  ::|.||:
  Fly  1764 RYPNTTCQPCNCHPDGIQTEGCDVETG-RCYCREGVTG------------------LKCDKCQ 1807

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Megf8NP_609180.3 CUB 33..141 CDD:238001
NanM <210..455 CDD:442289
KELCH repeat 228..268 CDD:276965
KELCH repeat 370..420 CDD:276965
KELCH repeat 425..476 CDD:276965
NanM 431..>630 CDD:442289 7/17 (41%)
KELCH repeat 480..540 CDD:276965
EGF_3 1186..1222 CDD:463759 12/55 (22%)
EGF_Lam 1257..1302 CDD:238012 19/47 (40%)
EGF_Lam 1304..1354 CDD:238012 15/75 (20%)
KELCH repeat 1585..1638 CDD:276965 6/52 (12%)
NanM 1596..1892 CDD:442289 24/296 (8%)
KELCH repeat 1642..1685 CDD:276965 4/42 (10%)
KELCH repeat 1760..1813 CDD:276965 0/52 (0%)
KELCH repeat 1817..1867 CDD:276965 0/49 (0%)
EGF_Lam 2299..2346 CDD:238012 17/47 (36%)
EGF_Lam 2422..2487 CDD:238012 14/55 (25%)
wbNP_723870.1 Laminin_N 153..398 CDD:459653 65/348 (19%)
EGF_Lam 401..450 CDD:238012 10/48 (21%)
EGF_Lam 505..552 CDD:238012 8/46 (17%)
Laminin_EGF 550..597 CDD:395007 12/53 (23%)
Laminin_B 660..813 CDD:459652 27/158 (17%)
EGF_Lam 851..900 CDD:238012 19/48 (40%)
Laminin_EGF <943..971 CDD:395007 10/27 (37%)
Laminin_EGF 974..1018 CDD:395007 10/89 (11%)
EGF_Lam 1017..1065 CDD:238012 18/110 (16%)
Laminin_EGF 1065..>1105 CDD:395007 12/47 (26%)
EGF_Lam 1150..1197 CDD:238012 16/110 (15%)
Laminin_EGF 1199..1247 CDD:395007 14/71 (20%)
EGF_Lam 1247..1292 CDD:238012 14/63 (22%)
Laminin_EGF 1294..1342 CDD:395007 10/47 (21%)
Laminin_EGF 1340..1392 CDD:395007 6/51 (12%)
Laminin_B 1486..1626 CDD:459652 29/171 (17%)
EGF_Lam 1669..1716 CDD:238012 17/48 (35%)
Laminin_EGF 1718..1767 CDD:395007 12/73 (16%)
EGF_Lam 1772..1819 CDD:238012 14/55 (25%)
YhaN <1907..2141 CDD:443752
SMC_prok_B <2123..>2390 CDD:274008
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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