DRSC/TRiP Functional Genomics Resources

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Protein Alignment Megf8 and LanB2

DIOPT Version :10

Sequence 1:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster
Sequence 2:NP_524006.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster


Alignment Length:1276 Identity:256/1276 - (20%)
Similarity:380/1276 - (29%) Gaps:520/1276 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   617 LLIVGGYHGNVNADLFAYELPQV-----LRVENTLYNPEISCRLHSSHTACLSNPECGWCSADSS 676
            ||::|....:.:..:...:.|.:     ..:..|.:.|.:.|  :..:    ..|:        .
  Fly    16 LLLIGVLFASCSTAILGAQRPPINSAGGHELRGTTFMPALEC--YDPY----GRPQ--------K 66

  Fly   677 CYGRTIGANCTTNLQTTRCPGICPSLGDCHSCLVHGSQWGKSSGNKAAFSVASKLGLNECTWCVQ 741
            |....|.|.....:::|   ..|....|.|.|:...:|..|:                 |.:|..
  Fly    67 CLPEFINAAYQLQIEST---NTCGEQNDNHFCIQTMNQNHKN-----------------CEFCKY 111

  Fly   742 NAKCHHRDDNYGICGD-----SSGWWGDKG--TEIRRPSLCTST---DRRPGLTYIKYHF----P 792
            |      |.|.....|     |..||..:.  ..|:.|:....|   .:...:||::..|    |
  Fly   112 N------DHNPSFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRP 170

  Fly   793 INYTMPDYVG---------IVNATMVDFASPPFTTYFEHKLEGEMLARLVGFVRPQHQWNNSAIQ 848
            .::|:.....         ..:||..|..|.|.:... .|.|||                  |..
  Fly   171 ESFTIYKRTSESGPWIPYQFYSATCRDTYSLPDSRAI-RKGEGE------------------AHA 216

  Fly   849 VCTSYSSAV--LRAG-----------LGLNLD---ELVNVTTQSSNQSYCSNVQLPTTEQPFTID 897
            :|||..|.:  ||.|           .|:|.:   ||....|              .|:...|:|
  Fly   217 LCTSEYSDISPLRDGEIAFSTLEGRPSGINFERSGELQEWVT--------------ATDIRITLD 267

  Fly   898 FQTRRRIGGNGIYNAYQKTKMELQHLH----------NGQLNAFTFEYLEPYYSGKC-------- 944
               |....|:.::...|..|.....:.          ||             ::.||        
  Fly   268 ---RLNTFGDELFGDSQVLKSYFYAISDIAVGARCKCNG-------------HASKCVPSTGMHG 316

  Fly   945 --TQYSNCLHCLTDASCAWC-PLTNICHLR-----SVNETEVCKMETL--DTFHWSYLISQPSQC 999
              |....|.|......|..| ||.|....:     .|||.:.|....|  ..|..:.|.::....
  Fly   317 ERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRTGHG 381

  Fly  1000 SNCTNY------VSCEACARS------GECEWWTEDARCGRIGKTNSSVRAVEHCPRSCR----- 1047
            .:|.:.      .:||.|..:      |.|    .:..|..:|  :.|::...|....|:     
  Fly   382 GHCLDCRENRDGPNCERCKENFYMRDDGYC----VNCACDPVG--SRSLQCNSHGKCQCKPGVTG 440

  Fly  1048 ---ER----------HGCQECLGERG-------------------------RCVWCE-------- 1066
               :|          ||||:|..:.|                         ||..|:        
  Fly   441 DKCDRCDNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDK 505

  Fly  1067 ----ASAQCFSFSVYTSE-------------YQFGMCRE-W---------VDQVVSRQTQEIA-- 1102
                ....||.:. :|||             ..|...:| |         ||...::.::.|.  
  Fly   506 NNRFGCTPCFCYG-HTSECMTAPGYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYSRSIGTT 569

  Fly  1103 ----DHKPQQTP-HFLQQQCKSCEQHRNCSSCLRTL----SCGWCFDRDNPIEG--------ICM 1150
                :|...|.| .||..|..|  .:|:....|:.:    :.|   ..|..:||        |..
  Fly   570 AQGNEHVYFQAPDRFLGDQRAS--YNRDLKFKLQLVGQVANTG---VSDVILEGAGSRISLPIFA 629

  Fly  1151 QGDFSYSAGNCSLALNSSSHHDAEWAYAQ------------------------------------ 1179
            ||:.....|..........|||.:|..:|                                    
  Fly   630 QGNGIPDQGVKEYTFRLHEHHDYQWQPSQSARGFLSILSNLTAIKIRATYSVQGEAILDDVELQT 694

  Fly  1180 -----------------CPD------VDECGLGLH---------------DCHKEAK-CTNTQGS 1205
                             ||:      .:.|..|..               |||..|. |.:..| 
  Fly   695 AHRGAAGHPATWIEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETG- 758

  Fly  1206 YNCHCRRGYIGDGKFSCVRTCYELCQNGNCSGPPDYTCRCALGWTGADCGLSCGCNNHSTC---N 1267
             .|.|:....||....|.:..|     ||           |||.|..|| ..|.|.|...|   |
  Fly   759 -RCICQHNTHGDNCDQCAKGFY-----GN-----------ALGGTPNDC-KRCPCPNDGACLQIN 805

  Fly  1268 ERLGKCDQCQDWSEGEKCERCRQGSYGNATAPHG----CLPCECNGHGNQD-LGVCNVSNGECY- 1326
            |....|.:|.....|.:||:|..|.:|:.|...|    |..|:|||:.:.: :|.||.:.|||. 
  Fly   806 EDTVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLK 870

  Fly  1327 CKDNTQGLNCELCAPGYYGDPRG--GGKC-YYQCESRGILTNIGKSAIGSYQSYRSPWGASLEVK 1388
            |..||.|.:|:.|..|::|||..  .|:| ...|...|                           
  Fly   871 CIHNTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYEAG--------------------------- 908

  Fly  1389 ECLWILQPKTLQAEKSLLQLEFQWQSLAMDCDENAVYIYDSLPDLTGATQQNQLLAVVCAPYSSP 1453
                     |.|.|:|:.:           ||:           :||..|        |    .|
  Fly   909 ---------TEQDEQSITR-----------CDQ-----------VTGQCQ--------C----KP 930

  Fly  1454 RII-----EARSSHVTVHYKQGSERRHFGFNALYSVMNCV---AGSCISPHICDAQQ-RCVCPAG 1509
            .:|     |.:..:..:....|.|             ||:   .||..|  .||... :|.|..|
  Fly   931 NVIGRDCGECQPGYFNIRSGNGCE-------------NCLCDPVGSYNS--TCDRYSGQCHCRPG 980

  Fly  1510 YVGASCE----------IEIC-PSNCNAKRMQGF-CDTEYGRCICSNANYAG------------- 1549
            .:|..|:          .|.| |..|:....:|| || :.|:|.| |.|..|             
  Fly   981 VMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQCD-QNGQCPC-NDNVEGRRCDRCKENKYDR 1043

  Fly  1550 -------ADCGTLVQ-RNHLVMTELFNTQLLSESLEHLRKT 1582
                   .||..||| ...|...:|||   ||::|:.:.:|
  Fly  1044 HRGCIDCPDCYNLVQDAADLHRAKLFN---LSQTLDEIART 1081

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Megf8NP_609180.3 CUB 33..141 CDD:238001
NanM <210..455 CDD:442289
KELCH repeat 228..268 CDD:276965
KELCH repeat 370..420 CDD:276965
KELCH repeat 425..476 CDD:276965
NanM 431..>630 CDD:442289 3/12 (25%)
KELCH repeat 480..540 CDD:276965
EGF_3 1186..1222 CDD:463759 12/51 (24%)
EGF_Lam 1257..1302 CDD:238012 16/51 (31%)
EGF_Lam 1304..1354 CDD:238012 22/54 (41%)
KELCH repeat 1585..1638 CDD:276965
NanM 1596..1892 CDD:442289
KELCH repeat 1642..1685 CDD:276965
KELCH repeat 1760..1813 CDD:276965
KELCH repeat 1817..1867 CDD:276965
EGF_Lam 2299..2346 CDD:238012
EGF_Lam 2422..2487 CDD:238012
LanB2NP_524006.1 LamNT 61..296 CDD:214532 57/308 (19%)
EGF_Lam 298..347 CDD:238012 12/61 (20%)
Laminin_EGF 359..414 CDD:395007 10/58 (17%)
EGF_Lam 414..458 CDD:214543 7/45 (16%)
Laminin_EGF 461..511 CDD:395007 5/49 (10%)
LamB 572..697 CDD:214597 22/129 (17%)
EGF_Lam 743..791 CDD:238012 20/66 (30%)
EGF_Lam 793..836 CDD:214543 14/42 (33%)
Laminin_EGF 847..897 CDD:395007 20/49 (41%)
Laminin_EGF 902..953 CDD:395007 15/120 (13%)
EGF_Lam 956..1001 CDD:214543 12/46 (26%)
Laminin_EGF 1004..1046 CDD:395007 11/43 (26%)
SMC_prok_B <1054..1621 CDD:274008 11/31 (35%)
Blue background indicates that the domain is not in the aligned region.

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