DRSC/TRiP Functional Genomics Resources

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Protein Alignment Megf8 and LanA

DIOPT Version :9

Sequence 1:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster
Sequence 2:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster


Alignment Length:2533 Identity:507/2533 - (20%)
Similarity:739/2533 - (29%) Gaps:986/2533 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   736 CTWCVQNAKCHHRDDNYGICGDSSGWW-------GDKGTEIR----------------------R 771
            |.:|.......:......|.| :..||       |.|..|:.                      |
  Fly    76 CDYCDPTVPERNHPPENAIDG-TEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPR 139

  Fly   772 PSLCT---STDRRPGLTYIKY-HFPINYTMPD---YVG------------IVNATMVDFASPPFT 817
            |.|.|   |||.  |.|:..: ||  :.|..|   |.|            ::..|......|   
  Fly   140 PGLWTLEKSTDY--GKTWTPWQHF--SDTPADCETYFGKDTYKPITRDDDVICTTEYSKIVP--- 197

  Fly   818 TYFEHKLE-GEMLARLVGFVRPQ--HQWNNSAIQVCTSYSSAVLRAGLGLN-LDELVNVTTQSSN 878
                  || ||:...|:. .||.  :.:|::.:|..|..::..:|.....| |..|::|..|.  
  Fly   198 ------LENGEIPVMLLN-ERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQD-- 253

  Fly   879 QSYCSNVQLPTTEQPFTIDFQTRR--------RIGGNGIYNAYQKTKMELQHLHNGQLNAFTFEY 935
                     ||.         |||        .|||..:.|.:                |.|.:.
  Fly   254 ---------PTV---------TRRYFYSIKDISIGGRCMCNGH----------------ADTCDV 284

  Fly   936 LEP-----YYSGKCTQYSNCLHCLTDASC------AWCPLTNI---------CHLRSVNETEVCK 980
            .:|     ..:.:|..::..:.|  :..|      .|...||.         ||..| ||   ||
  Fly   285 KDPKSPVRILACRCQHHTCGIQC--NECCPGFEQKKWRQNTNARPFNCEPCNCHGHS-NE---CK 343

  Fly   981 ME--------TLDTFHWSYLISQPSQCSNC---TNYVSCEACARS---GECEWWTEDARCGRIGK 1031
            .:        :|| .|..|  .....|.||   |..::|..|...   .:.:.|.|...|.    
  Fly   344 YDEEVNRKGLSLD-IHGHY--DGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCS---- 401

  Fly  1032 TNSSVRAVEHCPRSCRERHGCQECLGERGRCVWCEASAQ---CFSFSVYTSEYQFGMCREWVDQV 1093
                       |..|........|..|.|.|. |.|:.|   |.|.:.  ..|.:..|||....:
  Fly   402 -----------PCQCDYFFSTGHCEEETGNCE-CRAAFQPPSCDSCAY--GYYGYPNCRECECNL 452

  Fly  1094 VSRQTQEIADHKPQQTP---HFLQQQCKSCEQ----HRNCSSCLRTLSCGWCFDRDNPIEGICMQ 1151
            .............||.|   :|....||.|.:    ...|.:|    .|       |.|..|  .
  Fly   453 NGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKAC----EC-------NKIGSI--T 504

  Fly  1152 GDFSYSAGNCSLALN--SSSHHDAEWAYAQCPDVDECGLGLHDCHK---EAKCTNTQGSYNCHCR 1211
            .|.:.:.|.|....|  ..:....:..|...|....|     ||..   |::..|.| |..|.||
  Fly   505 NDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYC-----DCDNQGTESEICNKQ-SGQCICR 563

  Fly  1212 RGYIGDGKFSCVRTCYEL--CQNGNCSGPPDYTCRCALGWTGADCGLSCGCNNHSTCNERLGKCD 1274
            .|:.|.....|:...|..  |:..|||.            ||:.   :..|:|...||       
  Fly   564 EGFGGPRCDQCLPGFYNYPDCKPCNCSS------------TGSS---AITCDNTGKCN------- 606

  Fly  1275 QCQDWSEGEKCERCRQGSYGNATAPHGCLPCECNGHGNQDLGVCNVSNGECYCKDNTQGLNCELC 1339
             |.:...|::|..|..|.|...    .||||.|:.||:|.:. || |:|:|.|:.|..|..|:.|
  Fly   607 -CLNNFAGKQCTLCTAGYYSYP----DCLPCHCDSHGSQGVS-CN-SDGQCLCQPNFDGRQCDSC 664

  Fly  1340 APGYYGDPRGGGKCY-YQCESRGIL---TNIGKSAIGSYQSYRSPWGASL--EVKECLWILQPKT 1398
            ..|:|..|    .|. ..|:..|::   ...|...:|.....:......:  |.|...|.|....
  Fly   665 KEGFYNFP----SCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNECKPLYWNLNISN 725

  Fly  1399 LQAEKSLLQLEFQWQSLAMDC-DENAVYIYDSLPDLTGATQQNQLLAVVCAPYSSPRIIEARSSH 1462
            .:..:            ..|| .:..:...|:....:|...        |.|::..|        
  Fly   726 TEGCE------------ICDCWTDGTISALDTCTSKSGQCP--------CKPHTQGR-------- 762

  Fly  1463 VTVHYKQGSERRHFGFN----ALYSVMNC---VAGSCISPHICD-AQQRCVCPAGYVGASC---- 1515
                  :..|.|...|:    :|:...:|   |.||..|  :|| ...:|.|.....|.:|    
  Fly   763 ------RCQECRDGTFDLDSASLFGCKDCSCDVGGSWQS--VCDKISGQCKCHPRITGLACTQPL 819

  Fly  1516 ---------------EIEICPSNCNAK------RMQGFCDTEYGRCICSNANYAGADCGTLVQRN 1559
                           |....||....:      ...||....|   :..||          :|.:
  Fly   820 TTHFFPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSKGY---VVFNA----------IQND 871

  Fly  1560 HLVMTELFNTQL-------LSESLEHLRKTIPRFGHSVNADRRGSLWMFGGYSPNHGPLNDFRQF 1617
            ......:|.:.|       ::.:.|::..||     ||.:|               .||    :.
  Fly   872 VRNEVNVFKSSLYRIVLRYVNPNAENVTATI-----SVTSD---------------NPL----EV 912

  Fly  1618 DTKNSTWLQVTVESSTPEDRMPLGRYFHASEIYVKKQIIYIYGG-----IGANSQLLNDFWMFSI 1677
            |......||.|.|........|||         ||...|.:..|     ..||..::.|:::.. 
  Fly   913 DQHVKVLLQPTSEPQFVTVAGPLG---------VKPSAIVLDPGRYVFTTKANKNVMLDYFVLL- 967

  Fly  1678 QNQRWSQIKVEVEPPEADYEVDV-------PPPLAGHTL-THIRYQEHE------SLILLGGLSL 1728
                          |.|.||..:       |..|....| .|.:|...|      :..::|    
  Fly   968 --------------PAAYYEAGILTRHISNPCELGNMELCRHYKYASVEVFSPAATPFVIG---- 1014

  Fly  1729 NKSRPLELWEFNLDTGRWQQLAAVGARMPVLYGHTSVYH-------------------------- 1767
            ..|:|....|...|....|.::.|| .:|||.|..:..|                          
  Fly  1015 ENSKPTNPVETYTDPEHLQIVSHVG-DIPVLSGSQNELHYIVDVPRSGRYIFVIDYISDRNFPDS 1078

  Fly  1768 ------------QETNSVYLFGG-YST-----------EPQSNLYALDLQKL------------- 1795
                        .|| ||.|:.. |||           |....:...|||.:             
  Fly  1079 YYINLKLKDNPDSET-SVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRFP 1142

  Fly  1796 ----------SWT-----------------ELPSFREL------------------NSP--ASLL 1813
                      .|:                 ..|.||.:                  |.|  |||.
  Fly  1143 IISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASLD 1207

  Fly  1814 PRARYFHSAVTTEHYMILYG--GRTQPFNGTDVLIAY---------VY----------------- 1850
            .|.:..|.....|..:::..  ..|:| |...:|:.|         ||                 
  Fly  1208 ERVKLVHLDSQNEATIVIESKVDATKP-NLFVILVKYYQPSHPKYQVYYTLTAGKNQYDGKFDIQ 1271

  Fly  1851 ------ACNQWVR----------------LTED------VELIGRVPASSYAEDMAID---PDTG 1884
                  .|...:|                :|.|      ::.:..||...|.:|:.::   ..|.
  Fly  1272 HCPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQTK 1336

  Fly  1885 AIYVIGGWDGSSTHSHVTKITLPDDICQL--------WSNGKYQCRHYMGCSYCTIQNTYSYSSH 1941
            ......|.|    |.|:|...  .|.|:.        :::|...|    .|.|.   .:.|:..|
  Fly  1337 EFIQNCGHD----HFHITHNA--SDFCKKSVFSLTADYNSGALPC----NCDYA---GSTSFECH 1388

  Fly  1942 CFSHGRTPCANHNGTLVVNNGAACDDDWMASRNCS-----SFATC----GACLA----------- 1986
            .|. |:..|   ...::.....||...:....:|.     :.|.|    |.|:.           
  Fly  1389 PFG-GQCQC---KPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCEK 1449

  Fly  1987 ----AWPTHQEVAPVCHWCDDCGIRGRCVPAGV-------DCGRRSAWCNKELSVGVLGLCP--- 2037
                .:..||.:.     |::|.    |.|.|:       |....:..|.:.:......:|.   
  Fly  1450 CAPNTYGFHQVIG-----CEECA----CNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGY 1505

  Fly  2038 --LPQCYQLSC-------ESC-MLQPQCNWARNELG--TVECIAKELVEKNQYRVVESCPLPCHT 2090
              .|.|.|.||       |.| .:...|...:|.:|  ..:|:      ...|.:.||.|..|.|
  Fly  1506 FNFPHCEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCV------DGTYNLQESNPDGCTT 1564

  Fly  2091 ---YENCSLC---------------LSQTPTQDHQECKWSTMLNLCLTPSSQPLL---------- 2127
               :...|.|               :|.|..:.|:|   |...::...|:.:.||          
  Fly  1565 CFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEE---SIKFDMWPVPADEILLNETTLKADFT 1626

  Fly  2128 ---------CAGGVCGLVLEASELQRCPEPCHVYTQCSSCLEHAHCGWCAREGFNGDGICT---- 2179
                     ...||...:|..:.        |:...........|    ...||:|..|..    
  Fly  1627 LREVNDERPAYFGVLDYLLNQNN--------HISAYGGDLAYTLH----FTSGFDGKYIVAPDVI 1679

  Fly  2180 ----EGALEH-KQEHPSG-----------------------STCD-----------LIYASWRND 2205
                ..||.| ..|.||.                       |..|           .|.|::...
  Fly  1680 LFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQ 1744

  Fly  2206 SQLTH-ADVVSWHYVQCPAENECINGHHNCDTVSEQCIDLDTAVGYKCV-CAQGYREEQ-----G 2263
            :.:|| :||    |:....|:....|.:....| |:|.......|:.|. ||.||..:.     |
  Fly  1745 TLVTHLSDV----YLTLADEDADGTGEYQFLAV-ERCSCPPGYSGHSCEDCAPGYYRDPSGPYGG 1804

  Fly  2264 ACLPVCSQG------CVRGNC------VSPDQCQ-CDFGYVG-------ANCSIQCLC------- 2301
            .|:|....|      |..|.|      ...|.|: |..||.|       .:|.| |.|       
  Fly  1805 YCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMI-CACPLPFDSN 1868

  Fly  2302 NGHSNCESSSRLD-ICLKCHNNTMGEQCEKCQPLFVGNPRE-GHACQPCLDYCHGHSDVCVAYDA 2364
            |..::||.|...| |..:|.....|.:||.|...|.|.|.. |..|:||  .|.|        :.
  Fly  1869 NFATSCEISESGDQIHCECKPGYTGPRCESCANGFYGEPESIGQVCKPC--ECSG--------NI 1923

  Fly  2365 DPAVFNMTRSELERILQEGPAYNAT--CLRCGNHTAGDRCDSCLTGYFRGSEDLHKECRPCQCHG 2427
            :|.             .:|.....|  ||||.|:|.|..|:.|..|::..:..| |.|:.|.|..
  Fly  1924 NPE-------------DQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAIKL-KNCQSCDCDD 1974

  Fly  2428 HG-NICDPVTGEKCNCANNTESD------------------ATCTAGGGKNSAQL---------- 2463
            .| ..|||..| .|.|..|...|                  ..|..|...||.|.          
  Fly  1975 LGTQTCDPFVG-VCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCGAASNSTQCDPHTGHCACK 2038

  Fly  2464 ----------C----WMVQ---CSKCR------DSYAGNPTDGH-QCYKQITVESRMCFDAKP-- 2502
                      |    |..:   |:.|.      ..:..||..|. ||...:..:  .| ||.|  
  Fly  2039 SGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGD--RC-DACPNR 2100

  Fly  2503 --------IEECKSKPAALKPGQTVFFVIQPRFMNVDIRIIIDVTQGELDVFMSPQDDSFIVETN 2559
                    .:||.:...||                      :|||..     |..|.||.:.:.|
  Fly  2101 WVLIKDEGCQECNNCHHAL----------------------LDVTDR-----MRYQIDSVLEDFN 2138

  Fly  2560 ETT---------GYHEIFLDNRYNWGPKIKREHPLNVALPRHDNVTIQKLFSPERRIGGGGLGGG 2615
            ..|         .|::...|   ...||:|...|.:|.|            ||.::         
  Fly  2139 SVTLAFFTSQKLNYYDQLAD---ELEPKVKLLDPNSVDL------------SPSKK--------- 2179

  Fly  2616 GGERIGANTYYVPQLQ-DCKSHGGHNFIVKDQHAKDLSTHVTLNHCNTLLRLFGLKNRLVLTL 2677
                  ||:    :|: |.||           :||.::        .||...|.::.|...||
  Fly  2180 ------ANS----ELESDAKS-----------YAKQVN--------QTLANAFDIRERSSTTL 2213

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Megf8NP_609180.3 CUB 33..141 CDD:238001
KELCH repeat 228..268 CDD:276965
Kelch_4 369..414 CDD:290154
KELCH repeat 370..420 CDD:276965
KELCH repeat 425..476 CDD:276965
KELCH repeat 480..540 CDD:276965
EGF_3 1186..1220 CDD:289699 12/36 (33%)
EGF_Lam 1257..1302 CDD:238012 10/44 (23%)
EGF_Lam 1304..1354 CDD:238012 19/49 (39%)
CUB 1372..1484 CDD:238001 16/118 (14%)
Kelch_4 1584..1628 CDD:290154 8/43 (19%)
KELCH repeat 1585..1638 CDD:276965 10/52 (19%)
KELCH repeat 1642..1685 CDD:276965 7/47 (15%)
Kelch_3 1656..1710 CDD:290151 12/66 (18%)
KELCH repeat 1760..1813 CDD:276965 22/162 (14%)
Kelch_4 1760..1802 CDD:290154 15/131 (11%)
KELCH repeat 1817..1867 CDD:276965 13/105 (12%)
EGF_Lam 2299..2346 CDD:238012 17/55 (31%)
EGF_Lam 2422..2487 CDD:238012 24/117 (21%)
LanANP_476617.1 LamNT 18..271 CDD:214532 48/229 (21%)
EGF_Lam 272..>314 CDD:238012 7/59 (12%)
EGF_Lam 332..389 CDD:238012 17/63 (27%)
EGF_Lam 402..443 CDD:238012 12/43 (28%)
EGF_Lam 448..491 CDD:238012 7/42 (17%)
Laminin_EGF 495..543 CDD:278482 12/65 (18%)
Laminin_EGF 541..589 CDD:278482 15/53 (28%)
Laminin_EGF 587..634 CDD:278482 19/73 (26%)
EGF_Lam 631..673 CDD:238012 19/47 (40%)
Laminin_EGF 677..729 CDD:278482 8/51 (16%)
Laminin_EGF 732..782 CDD:278482 11/71 (15%)
EGF_Lam 785..828 CDD:238012 11/44 (25%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 34/180 (19%)
Laminin_EGF 1375..1423 CDD:278482 11/58 (19%)
EGF_Lam 1420..1457 CDD:238012 4/36 (11%)
Laminin_EGF 1466..1516 CDD:278482 10/53 (19%)
Laminin_EGF 1514..1562 CDD:278482 12/53 (23%)
LamB 1632..1760 CDD:214597 24/143 (17%)
Laminin_EGF <1775..1801 CDD:278482 7/25 (28%)
EGF_Lam 1808..1851 CDD:238012 11/42 (26%)
EGF_Lam 1859..1907 CDD:214543 15/47 (32%)
EGF_Lam 1916..1968 CDD:238012 19/75 (25%)
EGF_Lam 1969..2015 CDD:238012 11/46 (24%)
EGF_Lam 2016..>2054 CDD:238012 6/37 (16%)
EGF_Lam 2063..>2097 CDD:238012 8/36 (22%)
Laminin_I 2129..2385 CDD:283627 29/138 (21%)
Tar 2278..2662 CDD:223910
Laminin_II 2566..2700 CDD:283628
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45445165
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10574
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.030

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