Protein Alignment Megf8 and Ndg

DIOPT Version :10

• Sequence 1: NP_609180.3
• Gene: Megf8 / 34099
• FlyBaseID: FBgn0031981
• Length: 2892
• Species: Drosophila melanogaster
• Sequence 2: NP_610575.1
• Gene: Ndg / 36089
• FlyBaseID: FBgn0026403
• Length: 1350
• Species: Drosophila melanogaster
• Alignment Length: 1106
• Identity: 229/1106 - (20%)
• Similarity: 356/1106 - (32%)
• Gaps: 335/1106 - (30%)

  Fly  1543 SNANYAGADCGTLVQRNHLVMTELFNTQLLSESLEHLRKTIPRFGHSVNADRRG-----SLWMFG 1602
            ||.:.:.:|.||.:        .||.::  .:|:.....::.|:..|..::...     :.|...
  Fly   110 SNVDTSFSDEGTSI--------SLFESK--EQSILDRASSLVRYAFSSQSEFEARQVIVATWRNV 164

  Fly  1603 GY-SPNHGPLNDFR------------QFDTKNS--TWLQ-VTVESSTPEDRMPLGRYFHASEIYV 1651
            || ......||.|:            ||...:.  .||| .|.....|:.|...|........|.
  Fly   165 GYFDSKTDRLNTFQVALIANEQSTFVQFIYPDGGLNWLQGETAGLGLPDIRAQAGFVAEDGRFYT 229

  Fly  1652 KKQIIYIYGGIGANSQLLND--------FWMFS---IQNQRWSQIKVEVEPPEADYEVDVPPPLA 1705
                  :.|....|::.|::        .|:|.   |:|::      .|..|:....:...|.||
  Fly   230 ------LNGSGSENARFLSESTNLGVPGVWLFEVAPIENEQ------NVRSPDNAESLTESPALA 282

  Fly  1706 GHTLTHIRYQEHE----------------SLILLGGLS-LNKSRPLELWEFNLDTGRWQQLAAVG 1753
            .....| .:|.||                |.....|.| |...:|:.:      ||   .|....
  Fly   283 LSCQAH-AHQCHEKAECHDKAEGYCCVCGSGFYGNGKSCLANDQPIRV------TG---TLTGEL 337

  Fly  1754 ARMPVLYGHTSVYHQETNSVYLFGGYSTEPQSNLYALDLQKLSWTEL-PSFRELNSPASL-LPRA 1816
            .:.||                     |.|.:...|.:..:..::|.: |...||.:...| ||
  Fly   338 NKQPV---------------------SEEAKLQSYVVTSEGRTYTTINPLTPELGAQLRLVLP-- 379

  Fly  1817 RYFHSAVTTEHYMI------------LYGG------RTQPFNGTDVLIAYVY-ACNQWVRLTEDV 1862
                 .:||..::.            |.||      |.|..:|.::.:...: ..|.|.:|:..:
  Fly   380 -----LLTTVPWLFAKSVGGVANGYQLTGGVYTHVSRLQFDSGENLHVNQTFEGLNYWDQLSVKI 439

  Fly  1863 ELIGRVPASSYAEDMAIDPDTGAIYVIGGWDGSSTHSHVTKITLPDDICQLWSNGKYQCRHYMGC 1927
            |:.|.|||.: |:.:.|.||....|.... .|......|..|.:.::            :..:|.
  Fly   440 EIYGEVPAVA-ADAVLILPDYVEEYTFER-PGELKSVQVLNINITEE------------QRVLGL 490

  Fly  1928 SYCTIQNTYSYSSHCFSHGRTPCANHNGTLVVNNGAACDDDWM---ASRNCSSFATCGACLAAWP 1989
            .   ::....|.| |.   |...|:.:.|.|:...:....|::   .:....:.:..|
  Fly   491 Q---VEQRILYRS-CL---RDDEADPSATKVLQKISKVALDYVERDQALRIGAMSKVG------- 541

  Fly  1990 THQEVAPVCHWCD----DCGIRGRCVP----AGVDCGRRSAWCNKELSVGVLGLC-PLPQCYQLS 2045
                |.|..:.|:    ||.....|||    ...||....|....|..|.|   | .:.:| ...
  Fly   542 ----VTPESNACNDGTADCVENSVCVPYEDTYRCDCYHGFAAQLDERGVEV---CLDIDEC-ATG 598

  Fly  2046 CESCMLQPQCNWARNELGTVECIAKELVEKNQYRVVESCPLPCHTYENCSLCLSQTPTQDHQECK 2110
            ...|.....|:   |..|...|...|..|.|.||.:.:     .|.:|    :...|..:.|...
  Fly   599 SHVCDENAVCD---NTEGGFNCYCTEGFEGNGYRCLSN-----STADN----IEYPPAVEGQAEP 651

  Fly  2111 WSTMLNLCLTPSSQPLLCAGGVCGLVLEASELQR------------CPE---PCHVYTQCSSCLE 2160
            .|..     :|:..|....|       :..|.:|            .||   |.|. .:|..|.:
  Fly   652 TSEP-----SPNPSPYPDQG-------QDQEREREDDQYPQPNPYPYPEEQIPQHP-DECYRCSK 703

  Fly  2161 HAHC--GWC-AREGFNGDG-----ICTEGALEHK--------QEHPSGSTCDLIYASWRNDSQLT 2209
            .|.|  |.| ..|||:|||     ||..|.:...        :.|.....||.:     .:.:..
  Fly   704 DADCYQGRCTCHEGFDGDGYTCTNICGHGEVWENGRCEPLLLERHDVDPLCDAL-----GECRCP 763

  Fly  2210 HADVVSWHYVQCPAENECINGHHNCD----TVSEQCIDLDTAVGYK------CVCAQGYREEQGA 2264
            :...:|....:|....| .:|..|.|    .|.|.|....|...|.      |.|..|:|.:...
  Fly   764 YGYELSEDSQRCTYVQE-FDGERNADLIPCDVDENCHINATCNWYGQELRHICTCQPGFRGDGYN 827

  Fly  2265 CLPVCSQGC--------VRGNCV-----SPDQCQCDFGYV--GANCSIQCLCNGHSNCESSSRLD 2314
            |.|:....|        |..:||     ...:|||..||.  |.||.:...|....:|..::..|
  Fly   828 CDPISDDSCAIRPDICDVHADCVYEEHLGKSECQCQAGYTGNGFNCQLAAECQSAEHCGENAFCD 892

  Fly  2315 --ICLKCHNNTMGEQCEKCQPLFVGNPREGHACQPCLDYCHGHSDVCVAYDADPAVFNMTRSELE 2377
              :|             :||                .|:....||.||......:||..:.:..:
  Fly   893 DGVC-------------RCQ----------------ADFERDVSDRCVPAGRCGSVFCGSNAICK 928

  Fly  2378 RILQEGPAYNATCLRCGNHTAGDRCDSC----LTGYFRGSEDLHKECRP--------CQC----H 2426
            ....||..|   | .|.:...||....|    |:.:...:..:|..|.|        |||    .
  Fly   929 WDSAEGVQY---C-DCLDGYQGDALTGCTSKPLSCHVLNNCGIHATCEPTEDPANYECQCIAGFK 989

  Fly  2427 GHGNICDPVTGEKCNCANN---TESDATCTAGGGKNSAQLCWMVQCSKCRDSYAGNPTDGHQCYK 2488
            |.|.:|.    |:.||.||   .:.:|.|.:   .||..:|      .|...:.||   |..|.:
  Fly   990 GDGYVCI----EEQNCLNNPTLCDMNAQCRS---TNSGLVC------VCNQGFFGN---GSLCQE 1038

  Fly  2489 Q 2489
            :
  Fly  1039 R 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Megf8	NP_609180.3	CUB	33..141	CDD:238001
		NanM	<210..455	CDD:442289
		KELCH repeat	228..268	CDD:276965
		KELCH repeat	370..420	CDD:276965
		KELCH repeat	425..476	CDD:276965
		NanM	431..>630	CDD:442289
		KELCH repeat	480..540	CDD:276965
		EGF_3	1186..1222	CDD:463759
		EGF_Lam	1257..1302	CDD:238012
		EGF_Lam	1304..1354	CDD:238012
		KELCH repeat	1585..1638	CDD:276965	15/73 (21%)
		NanM	1596..1892	CDD:442289	73/365 (20%)
		KELCH repeat	1642..1685	CDD:276965	8/53 (15%)
		KELCH repeat	1760..1813	CDD:276965	8/54 (15%)
		KELCH repeat	1817..1867	CDD:276965	12/68 (18%)
		EGF_Lam	2299..2346	CDD:238012	6/48 (13%)
		EGF_Lam	2422..2487	CDD:238012	21/79 (27%)
Ndg	NP_610575.1	NIDO	108..262	CDD:214712	32/167 (19%)
		EGF_3	285..320	CDD:463759	6/35 (17%)
		G2F	322..549	CDD:214774	52/295 (18%)
		EGF_CA	591..622	CDD:429571	6/34 (18%)
		EGF_3	797..828	CDD:463759	7/30 (23%)
		EGF_3	836..873	CDD:463759	10/36 (28%)
		EGF_3	963..995	CDD:463759	8/31 (26%)
		EGF_3	1001..1036	CDD:463759	12/46 (26%)
		NHL	1074..>1254	CDD:302697
		NHL repeat	1074..1112	CDD:271320
		LY	1107..1145	CDD:214531
		NHL repeat	1117..1156	CDD:271320
		LY	1152..1195	CDD:214531
		NHL repeat	1161..1202	CDD:271320
		NHL repeat	1210..1244	CDD:271320