DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Megf8 and LanB1

DIOPT Version :9

Sequence 1:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster
Sequence 2:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster


Alignment Length:1837 Identity:343/1837 - (18%)
Similarity:546/1837 - (29%) Gaps:760/1837 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly  1159 GNCSLALNSSSHHDAEWAYAQCPDVDECGLGLHDCHKEAKCTNTQGSYNCHCRRGYIGDGKFSCV 1223
            |:||...::|.....:.|::|..:.|    |:  .|...:||:.....||.....:..|      
  Fly   286 GSCSCYGHASQCLPLDPAFSQADNED----GM--VHGRCECTHNTKGMNCEECEDFFND------ 338

  Fly  1224 RTCYELCQNGNCSGPPDYTCRCALGWTGA-----DCGLSCGCNNHS-TC--NERL---------G 1271
                                   |.|..|     :....|.||:|: :|  :|.:         |
  Fly   339 -----------------------LPWKPAFGKKTNACKKCECNDHAVSCHFDEAVFTASGFVSGG 380

  Fly  1272 KCDQCQDWSEGEKCERCRQGSY----GNATAPHGCLPCECNGHGNQDLGVCNVSN--------GE 1324
            .||.|...:.|:.||.|....|    .:.|:...|.||:|:..|:.|.|:|:..|        |.
  Fly   381 VCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGICDSLNELEEGAVAGA 445

  Fly  1325 CYCKDNTQGLNCELCAPGYYG----DPRGGGKCYYQCESRGILTNIGKSAIGSYQSYRSPWGASL 1385
            |:||....|..|..|..||:.    :|.|...|  .|...|.|.|.               |..:
  Fly   446 CHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPC--TCNPLGTLNNS---------------GCVM 493

  Fly  1386 EVKECLWILQPKTLQAEKSLLQLEFQWQSLAMDCDENAVYIYDSLPDLTGATQQNQLLAVVCAPY 1450
            ...||         :.:|.:         ...||::       .:|:..|.::            
  Fly   494 RTGEC---------KCKKYV---------TGKDCNQ-------CMPETYGLSE------------ 521

  Fly  1451 SSPRIIEARSSHVTVHYKQGSERRHFGFNALYSVMNCVAGSCISPHICDAQQRCVCPAGYVGASC 1515
                                                       ||..|..   |.|.||  |:  
  Fly   522 -------------------------------------------SPEGCSL---CNCDAG--GS-- 536

  Fly  1516 EIEICPSNCNAKRMQGFCDTEYGRCICSNANYAGADCGTLVQRNHLV--MTELFNTQLLSESLEH 1578
                         ...:||...|:|.| ..:..|..| :..::|:.:  :.|:...:::.|.:. 
  Fly   537 -------------YDNYCDVISGQCRC-RPHMTGRSC-SQPKQNYFIPLLPEVHEAEVVDECIS- 585

  Fly  1579 LRKTIPRFGHSVNADRRGSLWMFGGYSPNHGPLNDFRQFDTKNSTWLQVTVESSTPEDRMPLGRY 1643
                   :|.:.|.                                   ::.:.||:..      
  Fly   586 -------YGANGNC-----------------------------------SLVAETPDGS------ 602

  Fly  1644 FHASEIYVKKQIIYIYGGIG-----ANSQLLNDFWMFSIQNQRWSQIKVEVEPPEADYEVDVPPP 1703
                           :.|||     .||:|     :|::.                    |:|..
  Fly   603 ---------------FTGIGFTRVPENSEL-----VFTVG--------------------DIPRS 627

  Fly  1704 LAGHTLTHIRYQEHESLILLGGLSLNKSRPLELWEFNLDTGRWQQLAAVGARMPVLYGHTSVYHQ 1768
            :....:  ||||             :.||           |.|                      
  Fly   628 MPYDAV--IRYQ-------------STSR-----------GDW---------------------- 644

  Fly  1769 ETNSVYLFGGYSTEPQSNLYALDLQKLSWTELPSFRELNSPASLLPRARYFHSAVTTEHYMILYG 1833
            |...:.|......:|:.....|.....|.|.:        |.||..|:|    .|...:.:.|..
  Fly   645 ENAFITLVRPDQVDPEGGCGELAAATSSETRI--------PFSLPDRSR----QVVALNEVCLEA 697

  Fly  1834 GRTQPFNGTDVLIAYVYACNQWVRLTEDVELIGRVPASSYAEDMAIDPDTGAIYVIGGWDGSSTH 1898
            |:...|.        :|    :.|...||:   ...|:...:.:.:.|......:..|       
  Fly   698 GKVYKFR--------IY----FERKRHDVD---SPTATILVDSLTLIPRIDVTPIFQG------- 740

  Fly  1899 SHVTKITLPDDICQLWSNGKYQCRHYMGCSYCTIQNTYSYSSHCFSHGRTP-CANHNGTL--VVN 1960
            |.:..|...|       ..||.|:.               |.:..::...| |.|.:..|  .|:
  Fly   741 SVLADIRKKD-------YEKYNCKS---------------SLYDMNYKSDPKCQNLDNILSVFVH 783

  Fly  1961 NGAA---CDDDWMASRNCSSFATCGACLAAWPTHQEVAP--VCHWCDDC--GIRGRCVPAG---V 2015
            :||:   |:.....|:.|.|  ..|.|        :..|  |...||.|  |..| ..|.|   .
  Fly   784 DGASMCNCNPTGSLSKVCES--NGGYC--------QCKPNVVGRQCDQCAPGTYG-FGPEGCKAC 837

  Fly  2016 DC---GRRSAWCNKELSVGVLGLCP-LPQCYQLSCESCMLQPQCNWARNELGTVECIAKELVEKN 2076
            ||   |.:..:|:.     :.|.|. :|..|...|..|  ||. .|...|....:|        |
  Fly   838 DCNSIGSKDKYCDL-----ITGQCQCVPNTYGRECNQC--QPG-YWNFPECRVCQC--------N 886

  Fly  2077 QYRVVESCPLPCHTYENCSLCLSQTPTQDHQECKWSTMLNLCLTPSSQPLLCAGGVCGLVLEASE 2141
            .:...      |...:  ..|:         :|:.||....|.:       |..|..|..|..||
  Fly   887 GHAAT------CDPIQ--GTCI---------DCQDSTTGYSCDS-------CLDGYYGNPLFGSE 927

  Fly  2142 LQ----RCPEPCHVYTQCSSCLEHAHCGWCAREGFNGDGICTEGALEHKQEHPSGSTCDL----I 2198
            :.    ||||     |..|..   ||...|:.:..|.:.:|      |.||..|||.|::    .
  Fly   928 IGCRPCRCPE-----TVASGL---AHADGCSLDTRNNNMLC------HCQEGYSGSRCEICADNF 978

  Fly  2199 YASWRNDSQLTHADVVSWHYVQCPAENECING-----HHNCDTVSEQCIDLDTAVGYKCVCAQGY 2258
            :.:..|....:          :|    ||.|.     ..|||..:..|:        ||:    |
  Fly   979 FGNPDNGGTCS----------KC----ECSNNVDLYDTGNCDRQTGACL--------KCL----Y 1017

  Fly  2259 REEQGACLPVCSQG----CVRGNCVSPDQCQCDFGYVGANCSIQCLCNGHSNCESSSRLDICLKC 2319
            :.....| .:|..|    .::.||   .||:|||  :|.|.:|       ::|:..:....||. 
  Fly  1018 QTTGDHC-ELCKDGFFGDALQQNC---QQCECDF--LGTNNTI-------AHCDRFTGQCPCLP- 1068

  Fly  2320 HNNTMGEQCEKCQPLFVGNPREGH-------ACQPCLDYCHGHSDVCVAYDADPAVFNMTRSELE 2377
              |..|.:|::|        .|.|       .|:.|              :.||         :.
  Fly  1069 --NVQGVRCDQC--------AENHWKIASGEGCESC--------------NCDP---------IG 1100

  Fly  2378 RILQEGPAYNATCLRCGNHTAGDRCDSCLTGYFRGSEDLHKECRPCQCHGHGNI---CDPVTGEK 2439
            .:.::..:|...| :|.....|..|:.|...|:...   :::|:||:|...|..   ||..||  
  Fly  1101 ALHEQCNSYTGQC-QCKPGFGGRACNQCQAHYWGNP---NEKCQPCECDQFGAADFQCDRETG-- 1159

  Fly  2440 CNCANNTESDATCTAG-GGKNSAQLCWMVQCSKCRDSYAGNPTDGHQCYKQITVESRMCFD---- 2499
             ||        .|..| ||         .:|::|...|.|.......|.:        ||:    
  Fly  1160 -NC--------VCHEGIGG---------YKCNECARGYIGQFPHCSPCGE--------CFNNWDL 1198

  Fly  2500 ---------------AKPIEECKSKPAAL-------KPGQTVFFVIQPRFMN-VDIRIIIDVTQG 2541
                           ||.|::..:..|..       |..|.:..::|...:: |||..:...||.
  Fly  1199 ILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKLDYETQS 1263

  Fly  2542 ELDVFMSPQDDSFIVETNETTGYHEIFLDNRYN----WGPKIKREHPLNVALPRHDNVTIQKLFS 2602
            ..|...:........|.|         ||:.||    .|.:::       :|..|..: :|:| |
  Fly  1264 LRDQLQASHGRLSETEQN---------LDDIYNSLSLSGVELE-------SLQNHSRL-VQQL-S 1310

  Fly  2603 PERRIGGGGLGGGGGERIGANTYYVPQLQDCKSHGGHNFIVKDQHA----------KDLSTHVTL 2657
            .|.:..|                  .|||:....|..|.   .:||          ||.:..:..
  Fly  1311 KELKENG------------------IQLQESNIEGALNL---TRHAYERVSNLSTLKDEANELAS 1354

  Fly  2658 NHCNTLLRLFGLKNRLVLTLPQHAHN---LSATRFFIALRASSGPEPS----------------- 2702
            |......|:..|.|::.......|:|   :...|..:....|..||.:                 
  Fly  1355 NTDRNCKRVENLSNKIQAEADDLANNNKLIEDYRAELTSLTSQIPELNNQVCGKPGDPCDSLCGG 1419

  Fly  2703 -------------YGSVVFRQDQLHI--DLFVFFSVFFSCFFLFLAVCVIVWKVKQAADLRRARR 2752
                         :|:....::.|.:  |                |...|..|..||....||..
  Fly  1420 AGCGHCGGFLSCEHGAKTHSEEALKVAKD----------------AETAITSKKDQADQTIRALT 1468

  Fly  2753 Q---HVVEMLHLAKRPFAQ-----------------IFLASNGLDMDSPQPTSSSSSARAMRQRA 2797
            |   :..|....|||.|.|                 :|:|.|....:.   |:|.|.::.:.|:.
  Fly  1469 QAKLNASEAYEKAKRGFEQSERYLNQTNANIKLAENLFIALNNFQENK---TASPSESKELAQKT 1530

  Fly  2798 RQALLLQE----QSAGD 2810
            ....|..|    ::.||
  Fly  1531 LDLDLKLEPEEIETLGD 1547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Megf8NP_609180.3 CUB 33..141 CDD:238001
KELCH repeat 228..268 CDD:276965
Kelch_4 369..414 CDD:290154
KELCH repeat 370..420 CDD:276965
KELCH repeat 425..476 CDD:276965
KELCH repeat 480..540 CDD:276965
EGF_3 1186..1220 CDD:289699 7/33 (21%)
EGF_Lam 1257..1302 CDD:238012 16/60 (27%)
EGF_Lam 1304..1354 CDD:238012 19/61 (31%)
CUB 1372..1484 CDD:238001 8/111 (7%)
Kelch_4 1584..1628 CDD:290154 2/43 (5%)
KELCH repeat 1585..1638 CDD:276965 4/52 (8%)
KELCH repeat 1642..1685 CDD:276965 7/47 (15%)
Kelch_3 1656..1710 CDD:290151 9/58 (16%)
KELCH repeat 1760..1813 CDD:276965 8/52 (15%)
Kelch_4 1760..1802 CDD:290154 6/41 (15%)
KELCH repeat 1817..1867 CDD:276965 9/49 (18%)
EGF_Lam 2299..2346 CDD:238012 9/53 (17%)
EGF_Lam 2422..2487 CDD:238012 18/68 (26%)
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 343/1837 (19%)
EGF_Lam 287..343 CDD:238012 15/90 (17%)
Laminin_EGF 355..415 CDD:278482 16/59 (27%)
Laminin_EGF 418..475 CDD:278482 17/56 (30%)
EGF_Lam 477..526 CDD:238012 15/145 (10%)
EGF_Lam 529..567 CDD:214543 13/56 (23%)
EGF_Lam 789..834 CDD:214543 14/55 (25%)
Laminin_EGF 837..885 CDD:278482 14/55 (25%)
Laminin_EGF 883..930 CDD:278482 14/78 (18%)
Laminin_EGF 933..988 CDD:278482 19/68 (28%)
Laminin_EGF 991..1043 CDD:278482 16/71 (23%)
Laminin_EGF 1043..1091 CDD:278482 16/67 (24%)
Laminin_EGF 1094..1142 CDD:278482 11/74 (15%)
Laminin_EGF 1142..1190 CDD:278482 17/67 (25%)
COG6 1212..>1398 CDD:303003 44/224 (20%)
TelA 1439..1782 CDD:226371 27/128 (21%)
ApoLp-III_like 1545..1702 CDD:304399 2/3 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45445162
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10574
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.030

Return to query results.
Submit another query.