Protein Alignment Megf8 and Klhdc1

DIOPT Version :10

• Sequence 1: NP_609180.3
• Gene: Megf8 / 34099
• FlyBaseID: FBgn0031981
• Length: 2892
• Species: Drosophila melanogaster
• Sequence 2: NP_839984.1
• Gene: Klhdc1 / 271005
• MGIID: 2672853
• Length: 406
• Species: Mus musculus
• Alignment Length: 348
• Identity: 89/348 - (25%)
• Similarity: 127/348 - (36%)
• Gaps: 92/348 - (26%)

  Fly  1516 EIEICPSNCNAKRMQGFCDTEYGRCICSNANYAGA--DCGTLVQRNHLVMTELFNTQLLSESLEH 1578
            |.|:.||      |.|.|    |.||.......|.  |.|        ....|:...|.:....:
Mouse    62 EGELPPS------MSGSC----GACIHGRLYVFGGYDDKG--------YSNRLYFVNLRTRDGTY 108

  Fly  1579 LRKTIPRF-GHSVNADRRGSLWM-------FGGYS-PNHGPL--------------------NDF 1614
            ..:.|.:| |.......:.|.|:       ||||. ..|..|                    ||.
Mouse   109 TWEKITKFDGQPPTPRDKLSCWVYKDRLIYFGGYGYRRHSELQECFDVHDASWEEQIFWGWHNDV 173

  Fly  1615 RQFDTKNSTWLQVTVESSTPEDRMPLGRYFHASEIYVKKQIIYIYGGIGANSQLLNDFWMFSIQN 1679
            ..||||..||.|..::...|    |..|..|:..:...|.  |::||....:: :||....::..
Mouse   174 HVFDTKTRTWSQPEIKGGVP----PQPRAAHSCAVLGNKG--YVFGGRVLQTR-MNDLHYLNLDT 231

  Fly  1680 QRWS-QIKVEVEPPEADYEVDVPPPLAGHTLTHIRYQEHESLILLGGLSLNKSRPLELWEFNLDT 1743
            ..|| :|.|..|.|:         ..:.||||.|   ..:.|.|.|||:.:.....:.|..|:.|
Mouse   232 WVWSGRISVNGESPK---------HRSWHTLTAI---TDDKLFLFGGLNADNIPLSDGWIHNITT 284

  Fly  1744 GRWQQLAAVGARMPVLYGHTSVYHQETNSVYLFGGYSTEPQSNLYALD---------LQKLSWTE 1799
            ..|:||..:....|.|: ||:...:| |.:.:|||    .:.||..||         .|...::.
Mouse   285 NCWKQLRHLPYTRPRLW-HTACLGKE-NEIMVFGG----SKDNLLFLDTGHCNDLLIFQTQPYSL 343

  Fly  1800 LPSFRE--------LNSPASLLP 1814
            |.|..:        |.|..||||
Mouse   344 LRSCLDCIGKNAIILKSQISLLP 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Megf8	NP_609180.3	CUB	33..141	CDD:238001
		NanM	<210..455	CDD:442289
		KELCH repeat	228..268	CDD:276965
		KELCH repeat	370..420	CDD:276965
		KELCH repeat	425..476	CDD:276965
		NanM	431..>630	CDD:442289
		KELCH repeat	480..540	CDD:276965
		EGF_3	1186..1222	CDD:463759
		EGF_Lam	1257..1302	CDD:238012
		EGF_Lam	1304..1354	CDD:238012
		KELCH repeat	1585..1638	CDD:276965	20/81 (25%)
		NanM	1596..1892	CDD:442289	71/265 (27%)
		KELCH repeat	1642..1685	CDD:276965	10/43 (23%)
		KELCH repeat	1760..1813	CDD:276965	17/69 (25%)
		KELCH repeat	1817..1867	CDD:276965
		EGF_Lam	2299..2346	CDD:238012
		EGF_Lam	2422..2487	CDD:238012
Klhdc1	NP_839984.1	NanM	10..321	CDD:442289	76/301 (25%)
		KELCH repeat	13..66	CDD:276965	2/3 (67%)
		Kelch 1	24..76		8/23 (35%)
		KELCH repeat	70..120	CDD:276965	13/61 (21%)
		Kelch 2	80..134		10/61 (16%)
		Kelch 3	135..181		12/45 (27%)
		KELCH repeat	197..245	CDD:276965	13/50 (26%)
		Kelch 4	208..258		17/64 (27%)
		KELCH repeat	248..295	CDD:276965	16/49 (33%)
		Kelch 5	260..307		15/47 (32%)
		Kelch 6	311..361		11/53 (21%)