DRSC/TRiP Functional Genomics Resources

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Protein Alignment Megf8 and Atrnl1

DIOPT Version :10

Sequence 1:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster
Sequence 2:NP_852080.3 Gene:Atrnl1 / 226255 MGIID:2147749 Length:1378 Species:Mus musculus


Alignment Length:1798 Identity:374/1798 - (20%)
Similarity:569/1798 - (31%) Gaps:725/1798 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly  1304 PCECNGHGNQDLGVCNVSNGECY---CKDNTQGLNCELCAPGYYGDPRGGGKCYYQCESR----- 1360
            |||              ..|.|:   |.::|    | ||.||:.||     :|.: |:.|     
Mouse    61 PCE--------------RTGSCFSGRCVNST----C-LCDPGWVGD-----QCQH-CQGRFKLTE 100

  Fly  1361 --GILTNIGKSAIGSYQSYRSPWGASLEVKECLWILQ--PKTLQAEKSLLQLEFQWQSLAMDCDE 1421
              |.||:             .|.....:.| |.|:::  |      .::|:|.|  ...|.:|..
Mouse   101 PSGYLTD-------------GPINYKYKTK-CTWLIEGYP------NAVLRLRF--NHFATECSW 143

  Fly  1422 NAVYIYDS---------------LPDLTGATQQNQLLAVVCAPYSSPRIIEARSSHVTVHYKQGS 1471
            :.:|:||.               :|::.|    |:.:         |.:: ..|.:..:|:...:
Mouse   144 DHMYVYDGDSIYAPLVAVLSGLIVPEVRG----NETV---------PEVV-TTSGYALLHFFSDA 194

  Fly  1472 ERRHFGFNALYSVMNCV-----AGSCISPHICDAQQRCVCPAGYVGASCEIEICPSNCNAKRMQG 1531
            .....|||..||:.:|.     .|.|.:.....:|..|.|...:.|.:|:|..|.:||.:.. .|
Mouse   195 AYNLTGFNIFYSINSCPNNCSGHGKCTTSVSVASQVYCECDKYWKGEACDIPYCKANCGSPD-HG 258

  Fly  1532 FCD-TEYGRCICSNANYAGADCGTLVQRNHLVMTELF----NTQLLSESLEHLRKTIPRFGHSVN 1591
            :|| |....|:| |.::.|.||..     ::..||.:    |.:..|.|       :.|..|  .
Mouse   259 YCDLTGEKLCVC-NDSWQGPDCSL-----NVPSTESYWILPNVKPFSPS-------VGRASH--K 308

  Fly  1592 ADRRGS-LWMFGGYSPNHGPLNDFRQFDTKNSTWLQVTVESSTPEDRMPLGRYFHASEIYVKKQI 1655
            |...|. :|:.|||:.|:........::.::|.|....|      .|.||.||.|:..:|  ::.
Mouse   309 AVLHGKFMWVIGGYTFNYSSFQMVLNYNLESSIWNVGAV------SRGPLQRYGHSLALY--QEN 365

  Fly  1656 IYIYGG--IGANSQLLNDFWMFSIQNQRWSQIKVEVEPPEADYEVDVPPPLAGHTLTHIRYQEHE 1718
            |::|||  ..::..:.::.|:|::::|.||.....|......|.|:      ||: .||  .|.:
Mouse   366 IFMYGGRMETSDGNVTDELWVFNVRSQSWSTKTPTVLGHSQQYAVE------GHS-AHI--MELD 421

  Fly  1719 S----LILLGGLSLNKSRPLELWEFNLDTGRWQQLAAVGARMPVLYGHTSVYHQETNSVYLFGGY 1779
            |    :|::.|.|........:.|:::.:..|......||.:...|||||||.:.|.|:|:.|||
Mouse   422 SRDVVMIVIFGYSAIYGYTSSIQEYHISSNTWLVPETKGAIVQGGYGHTSVYDEVTKSIYVHGGY 486

  Fly  1780 STEPQS------NLYALDLQKLSWTELPSFRELNSPASLLPRARYFHSAVTTEHYMILYGGRTQP 1838
            ...|.:      :||..::...:||.|   :|...       |||.||||.....|:::||.|. 
Mouse   487 KALPGNKYGLVDDLYKYEVNTRTWTIL---KESGF-------ARYLHSAVLINGAMLIFGGNTH- 540

  Fly  1839 FNGTDV----------LIAYVYACNQWVRLTE-----DVELIGRVPASSYAEDMAIDPDTGAIYV 1888
             |.|.:          .:||..||::|..|.:     ||...|.       ..:.|:   |::|:
Mouse   541 -NDTSLSNGAKCFSADFLAYDIACDEWKTLPKPNLHRDVNRFGH-------SAVVIN---GSMYI 594

  Fly  1889 IGGWDGSSTHSHVTKITLPDDI-------CQLWSNGKYQCRHYMGCSYCTIQNTYSYSSHCFSHG 1946
            .||:..          .|.:||       |:.:.:.:. ||: .|.....:.|    .:||.|  
Mouse   595 FGGFSS----------VLLNDILVYKPPNCKAFRDEEL-CRN-AGPGIKCVWN----KNHCES-- 641

  Fly  1947 RTPCANHNGTLVVN---NGAACDDDWMASRNCSSFATCGACLAAWPTHQEVAPVCHWCDDCGIRG 2008
             ....|.|..|...   ..||.||      .|..:|.|.:|.|.       ...|.||||    .
Mouse   642 -WESGNTNNILRAKCPPKTAATDD------RCYRYADCASCTAN-------TNGCQWCDD----K 688

  Fly  2009 RCVPAGVDCG-----------RRSAWCNKELSVGVLGLCPLPQCYQLSCESCMLQPQCNWAR--- 2059
            :|:.|..:|.           |....|||                ..||:||.|...|.|.:   
Mouse   689 KCISASSNCSTSVRNYTKCHIRNEQICNK----------------LTSCKSCSLNLNCQWDQRQQ 737

  Fly  2060 --------------NELG----------------------------------TVECIAKELVEKN 2076
                          |.:|                                  .||.:..|:.:..
Mouse   738 ECQALPAHLCGEGWNHVGDACLRINSSRESYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKFT 802

  Fly  2077 QYRV------------------------------------------------------------- 2080
            |.:|                                                             
Mouse   803 QQKVSPWVGLRKINISYWGWEDMSPFTNTSLQWLPGEPNDSGFCAYLERAAVAGLKANPCTSMAD 867

  Fly  2081 --------------VESCPLPCHTYENCSLCLSQTPTQDHQECKWSTMLNLCLTPSSQPLLCAGG 2131
                          ...|..||....:|:.|     |....||.|.:....|:..::..:....|
Mouse   868 GLVCEKPVVSPNQNARPCKKPCSLRTSCANC-----TSSGMECMWCSSTKRCVDSNAYIISFPYG 927

  Fly  2132 VCGLVLEASELQRCPEPCHVYTQCSSCLEHAHCGWCAREGFNGDGICTEGALEHKQEHPSGSTCD 2196
            .|   ||.......|:.|.....|..|||...||||......|.|.|.||:.....:.......|
Mouse   928 QC---LEWQTATCSPQNCSGLRTCGQCLEQPGCGWCNDPSNTGRGYCIEGSSRGPMKLAGVHNSD 989

  Fly  2197 LIYASWRNDSQLTHADV-VSWHYVQCPAENECINGHHNCDTVSEQCIDLDTAVGYKCVCAQGYRE 2260
            ::.     |:.|...:. ..|.::||||                                     
Mouse   990 VVL-----DTSLCPKEKNYEWSFIQCPA------------------------------------- 1012

  Fly  2261 EQGACLPVCSQGCVRGNCVSPDQCQCDFGYVGANCSIQCLCNGHSNCESSSRLDICLKCHNNTMG 2325
                                                  |.|||||.|.::   ::|.:|.|.|.|
Mouse  1013 --------------------------------------CQCNGHSTCINN---NVCEQCKNLTTG 1036

  Fly  2326 EQCEKCQPLFVGNPREGHACQPCLDYCHGHSDVCVAYDADPAVFNMTRSELERILQEGPAYNATC 2390
            .||::|.|.:.|:|..|                                                
Mouse  1037 RQCQECMPGYYGDPTNG------------------------------------------------ 1053

  Fly  2391 LRCGNHTAGDRCDSCLTGYFRGSEDLHKECRPCQCHGHGNICDPVTGEKCNCANNTESDATCTAG 2455
                                       .:|..|.|.||.|:|...|| ||          .||..
Mouse  1054 ---------------------------GQCTACTCGGHANVCHLHTG-KC----------FCTTK 1080

  Fly  2456 GGKNSAQLCWMVQCSKC--RDSYAGNPTDGHQCYKQITVESRMCFDAKPIEECKSKPAALKPGQT 2518
            |.|..       ||..|  .:.|.|||..| .||..:.::.:..|..  ::|......|:.    
Mouse  1081 GIKGD-------QCQLCDSENRYVGNPLRG-TCYYSLLIDYQFTFSL--LQEDDRHHTAIN---- 1131

  Fly  2519 VFFVIQPRFMNVDIRIIIDVTQGELDVFMSPQDDSFIVETNETTGYHEIFLDNRYNWGPKIKREH 2583
              |:..|...|.::.|.|:.:                               |.:|         
Mouse  1132 --FIANPEQSNKNLDISINAS-------------------------------NNFN--------- 1154

  Fly  2584 PLNVALPRHDNVTIQKLFSPERRIGGGGLGGGGGERIGANTYYV-----PQLQDCKSHGGHNFIV 2643
             ||:.                     ..:|..||...|..|..|     .:.:|..|:...||  
Mouse  1155 -LNIT---------------------WSVGSTGGTISGEETPIVSKTNIKEYRDSFSYEKFNF-- 1195

  Fly  2644 KDQHAKDLSTHVTLNHCNTLLRLFGLKNRLVLTLPQHAHNLSATRFFIALRASSGPEPSYGSVVF 2708
                                      ::...:|...:..|.|              .|....:.|
Mouse  1196 --------------------------RSNPNITFYVYVSNFS--------------WPIKIQIAF 1220

  Fly  2709 RQDQLHIDLFVFFSVFFSCFFLFLAVCVIVWKVKQAADLRRARRQHVVEMLHLAKRPFAQIFLAS 2773
            .|....:||..||..|||||...|.|..:|||:||.....|.|.|.:.|...:|.||||.:.:  
Mouse  1221 SQHNTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLLRERQQMASRPFASVDV-- 1283

  Fly  2774 NGLDMDSPQPTSSSSSARAMRQRARQALLLQEQSAGDSQSVMHHSTRRQSSRIMMVAIEPTFDNL 2838
                              |:...|.|...|:....|..:.               :||||...|.
Mouse  1284 ------------------ALEVGAEQTDFLRGPLEGAPKP---------------IAIEPCAGNR 1315

  Fly  2839 AAVGTVFISLP-GRSRAP----LSIALGSTLISYSRQYPLNTR 2876
            |||.|||:.|| |.|.||    ..:|:.|.||..|:|.|.:.:
Mouse  1316 AAVLTVFLCLPRGSSGAPPPGQSGLAIASALIDISQQKPSDNK 1358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Megf8NP_609180.3 CUB 33..141 CDD:238001
NanM <210..455 CDD:442289
KELCH repeat 228..268 CDD:276965
KELCH repeat 370..420 CDD:276965
KELCH repeat 425..476 CDD:276965
NanM 431..>630 CDD:442289
KELCH repeat 480..540 CDD:276965
EGF_3 1186..1222 CDD:463759
EGF_Lam 1257..1302 CDD:238012
EGF_Lam 1304..1354 CDD:238012 14/52 (27%)
KELCH repeat 1585..1638 CDD:276965 12/53 (23%)
NanM 1596..1892 CDD:442289 87/323 (27%)
KELCH repeat 1642..1685 CDD:276965 13/44 (30%)
KELCH repeat 1760..1813 CDD:276965 20/58 (34%)
KELCH repeat 1817..1867 CDD:276965 20/64 (31%)
EGF_Lam 2299..2346 CDD:238012 19/46 (41%)
EGF_Lam 2422..2487 CDD:238012 22/66 (33%)
Atrnl1NP_852080.3 CUB 92..207 CDD:238001 28/150 (19%)
DSL 234..280 CDD:473190 16/47 (34%)
NanM 302..597 CDD:442289 89/335 (27%)
KELCH repeat 304..352 CDD:276965 13/55 (24%)
Kelch 1 315..364 15/56 (27%)
KELCH repeat 354..407 CDD:276965 14/54 (26%)
Kelch 2 366..414 13/53 (25%)
Kelch 3 426..474 13/47 (28%)
Kelch 4 479..530 19/60 (32%)
KELCH repeat 520..573 CDD:276965 18/54 (33%)
Kelch 5 532..590 16/69 (23%)
Kelch 6 591..637 11/61 (18%)
CLECT_attractin_like 747..873 CDD:153067 7/125 (6%)
PSI 888..937 CDD:396154 13/56 (23%)
EGF_Lam 1012..1057 CDD:238012 20/197 (10%)
Interaction with MC4R. /evidence=ECO:0000269|PubMed:14531729 1287..1324 15/51 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1351..1378 2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

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