DRSC/TRiP Functional Genomics Resources

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Protein Alignment Megf8 and FBN1

DIOPT Version :10

Sequence 1:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster
Sequence 2:NP_000129.3 Gene:FBN1 / 2200 HGNCID:3603 Length:2871 Species:Homo sapiens


Alignment Length:2963 Identity:537/2963 - (18%)
Similarity:823/2963 - (27%) Gaps:1180/2963 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   141 ISNCLNNCHNHGKCVGHQCVCHGEWVGPDCEDEACPQRCGESQGRGRC-QKSICHCSRGYSGRLC 204
            |.:|...|.|.|.|....|:|...::|..|....|...|   ...||| ..:.|.|:.|::|..|
Human   116 IQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGC---LNGGRCVAPNRCACTYGFTGPQC 177

  Fly   205 DLSDHPAGSSWRWLATD-AEGMTARAAHSAVYMEDEDALYVFGGYDLNNVISTLQIYRFSTSQWE 268
            : .|:..|..:..::.. .:|                        .|:.::.|..:...:..:  
Human   178 E-RDYRTGPCFTVISNQMCQG------------------------QLSGIVCTKTLCCATVGR-- 215

  Fly   269 DEWGIALQSRRHFYHP--------------QKID----------------------------HTL 291
             .||...:......||              |.:|                            |.|
Human   216 -AWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKL 279

  Fly   292 LKAVLQHKNEDE-AKLWGL-------NSDVSFFRNI---LYTLAESN-------------LHQRR 332
            .:...:.::.|| :.:.|:       |:..|:|...   .||..:..             |...|
Human   280 NEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGR 344

  Fly   333 TRSSLPLTIVNAN----------------------STDEELN-------------EYLEDILEEV 362
            ..:.||.:|....                      ...|:.|             ||....|..:
Human   345 CSNQLPQSITKMQCCCDAGRCWSPGVTVAPEMCPIRATEDFNKLCSVPMVIPGRPEYPPPPLGPI 409

  Fly   363 TDHKPHGRYGHAADSVPGGF--------------VIYGGKH------ANGSFYSDLWQYNNTESG 407
            ....|          ||.||              .:|..:.      .|.:.|..|.:| ..::|
Human   410 PPVLP----------VPPGFPPGPQIPVPRPPVEYLYPSREPPRVLPVNVTDYCQLVRY-LCQNG 463

  Fly   408 GKWKQMAIRSAVKPPALARHTLNTAGSYLYIFGGSLETGEFSSSVYRIPLPLSEDSQWELVQPRG 472
                     ..:..|...|...| .|..|.:.|..::..|...:      |.:..   |.:..:|
Human   464 ---------RCIPTPGSYRCECN-KGFQLDLRGECIDVDECEKN------PCAGG---ECINNQG 509

  Fly   473 GKTLDVRLAAHSTVYYKATNSL--IVFGGIMTSLARFSKLSDRIYAFQLDQMHWT---------- 525
            ..|...|....||:.......:  .:..|.:.:..|........:.......|.|          
Human   510 SYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMD 574

  Fly   526 EILYPRTALRDTNIPRERAFHTATISGNYMVVFGGYTHRHNKDE---ICYDNQ------MYWYHL 581
            |.......|....|..:.:|......|..:...|.|....|:.|   ||.:.:      .|    
Human   575 ECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSY---- 635

  Fly   582 SCHIWINQVVSADDSLYPKPQGVFAHAAALRRNHTLLIVGGY-HGNVNADLFAYELPQVLRVENT 645
            .|..:....|..|..:.     |..|..:       ...||| .|.....||...........:|
Human   636 RCECFPGLAVGLDGRVC-----VDTHMRS-------TCYGGYKRGQCIKPLFGAVTKSECCCAST 688

  Fly   646 LY---NPEISCRLHSS---HTACLSNPECGWCSADSSCYGRTIGANCTTNLQTTRCP-GICPSLG 703
            .|   .|...|...:|   ...|.|.|  |..||.|..      ..|.  |....|| |||.:|.
Human   689 EYAFGEPCQPCPAQNSAEYQALCSSGP--GMTSAGSDI------NECA--LDPDICPNGICENLR 743

  Fly   704 DCHSCLVHGSQWGKSSGNKAAFSVASKLGLNEC---TWCVQNAKCHHRDDNYGICGDSSGWWGDK 765
            ..:.|:.:......|:|...       :.:|||   :....|.:|.:...:: :|....|:    
Human   744 GTYKCICNSGYEVDSTGKNC-------VDINECVLNSLLCDNGQCRNTPGSF-VCTCPKGF---- 796

  Fly   766 GTEIRRPSLCTSTD-----RRPGLTYIKYHFPINYTMPDYVGIVNATMVDFASPPFTTYFEHKLE 825
               |.:|.|.|..|     ..|.:..:..:.|.::       |...:......|..|...| .::
Human   797 ---IYKPDLKTCEDIDECESSPCINGVCKNSPGSF-------ICECSSESTLDPTKTICIE-TIK 850

  Fly   826 GEMLARLVGFVRPQHQWNNSAI--QVCTSYSSA-------------------------------- 856
            |.....::. .|.:...|.:.:  |.|:|..:|                                
Human   851 GTCWQTVID-GRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDEC 914

  Fly   857 -----VLRAGLGLNLDELVNVTTQSSNQSYC-SNVQLPTTEQPFTIDFQTRRRIGGNGIYNAYQK 915
                 |.:.||.:|        |:.|.:..| |.:.|..|.: ..:|.                 
Human   915 EVFPGVCKNGLCVN--------TRGSFKCQCPSGMTLDATGR-ICLDI----------------- 953

  Fly   916 TKMELQHLHNGQLNAFTFEYLEPYYSGKCTQYSNCLH----CLTDASCAW-------CPLTN--- 966
             ::|...|.              |...:||......|    |......||       ||:.|   
Human   954 -RLETCFLR--------------YEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPE 1003

  Fly   967 ---IC----------------HLRSVNETEVCKM-----------ETLDTF--HWSYLISQPSQC 999
               :|                ..:.:||   |||           .|:.:|  ......:..|:.
Human  1004 YEELCPRGPGFATKEITNGKPFFKDINE---CKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEE 1065

  Fly  1000 SNCTNYVSC----EACARSGECEWWTEDARCGRIGKTNSSVRA----------VEHCPRS----- 1045
            .|||:...|    :.|.| |:|.....|..|    |.:....:          ::.|.|.     
Human  1066 RNCTDIDECRISPDLCGR-GQCVNTPGDFEC----KCDEGYESGFMMMKNCMDIDECQRDPLLCR 1125

  Fly  1046 ---CRERHGCQEC--------------------------LGERGRCVWCEASAQC---------- 1071
               |....|...|                          |...||||......||          
Human  1126 GGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTP 1190

  Fly  1072 ---FSFSVYTSEYQFGMCREWVDQVVSRQTQEIADHKPQQTPHFL----QQQC---KSCEQHRN- 1125
               |...:.......|.|..:.       |.....::....|.|.    |:.|   ..||.:.| 
Human  1191 DRLFCVDIDECSIMNGGCETFC-------TNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNI 1248

  Fly  1126 -----CSSCLRTLSCGWCFD-----RD------------NPIEGICMQGDFSYSAGNCSLALNSS 1168
                 |::......| .|:|     .|            ||  .||:.|....:.|  |...:..
Human  1249 CDGGQCTNIPGEYRC-LCYDGFMASEDMKTCVDVNECDLNP--NICLSGTCENTKG--SFICHCD 1308

  Fly  1169 SHHDAEWAYAQCPDVDECGLGLHDCHKEAKCTNTQGSYNCHCRRGYIGDGKFSCVRTCYELCQNG 1233
            ..:..:.....|.|::||.:|.|:|.|.|.||||.||:.|.|..|:|||| ..|  |..:.|.||
Human  1309 MGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDG-IKC--TDLDECSNG 1370

  Fly  1234 N--CSGPPD-------YTCRCALGWTGADCGLSCGCNNHSTCNERLGKC--DQCQDWSEGEKCER 1287
            .  ||...|       |.|.|..|:||.  |.:  |.:...|:|.|..|  .||.:...|.:|| 
Human  1371 THMCSQHADCKNTMGSYRCLCKEGYTGD--GFT--CTDLDECSENLNLCGNGQCLNAPGGYRCE- 1430

  Fly  1288 CRQGSYGNATAPHGCLPCECNGHGNQDLGVCNVSN----GECYCKDNTQGL-NCELCAPGYYGDP 1347
            |..|...:|           :|...:|:..|::.|    |.|:   |..|| .|| |..||..| 
Human  1431 CDMGFVPSA-----------DGKACEDIDECSLPNICVFGTCH---NLPGLFRCE-CEIGYELD- 1479

  Fly  1348 RGGGKCYYQCESRGILTNIGKSAIGSYQSYRSPWGASLEVKECLWILQPKTLQAEKSLLQLEFQW 1412
            |.||.|                               .:|.||   |.|.|              
Human  1480 RSGGNC-------------------------------TDVNEC---LDPTT-------------- 1496

  Fly  1413 QSLAMDCDENAVYIYDSLPDLTGATQQNQLLAVVCAPYSSPRIIEARSSHVTVHYKQGSERRHFG 1477
                                                                             
Human  1497 ----------------------------------------------------------------- 1496

  Fly  1478 FNALYSVMNCVAGSCIS---PHICDAQQRCVCPAGY------VG------ASCEIEICPSNCNAK 1527
                     |::|:|::   .:|||      ||..:      ||      .:|.::|.|...|..
Human  1497 ---------CISGNCVNTPGSYICD------CPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGD 1546

  Fly  1528 RMQGFCDTEYG------RCICSNANYAGADCGTLVQRNHLVMTELFNTQLLSESLEHLRKTIPRF 1586
            ..   |..|.|      .|.||.....|..|                            :..|  
Human  1547 TA---CSNEIGVGVSKASCCCSLGKAWGTPC----------------------------EMCP-- 1578

  Fly  1587 GHSVNADRRGSLWMFG-GYSPNHGPLNDFRQFDTKNSTWLQVTVESSTPEDRMPLGRYFHASEIY 1650
              :||......|...| |:.||  |:.              |.:|.......:|           
Human  1579 --AVNTSEYKILCPGGEGFRPN--PIT--------------VILEDIDECQELP----------- 1614

  Fly  1651 VKKQIIYIYGGIGANSQLLNDFWMFSI---------QNQRWSQIKVEVEPP-----------EAD 1695
                      |:....:.:|.|..|..         ::.|......|.|.|           ..:
Human  1615 ----------GLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGN 1669

  Fly  1696 YEVDVPPPL----AGHTLTHIR--------YQEHESLILLGGLSLNKSRPLELWEFNLDTGRWQQ 1748
            |....||..    .|:....:|        |.::::..  |.|..|.::.:....:|:  ||   
Human  1670 YTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCD--GELLFNMTKKMCCCSYNI--GR--- 1727

  Fly  1749 LAAVGARMPVLYGHTSVYHQETNSVYLFGGYSTEPQSNLYALDLQKLSWTELPSFRELNSPASLL 1813
                                                           :|         |.|....
Human  1728 -----------------------------------------------AW---------NKPCEQC 1736

  Fly  1814 PRARYFHSAVTTEHYMILYGGRTQPF-----------------------NGTDVLIAYVYAC--- 1852
            |       ..:|:.:..|.|.:...|                       ||..:.:...:.|   
Human  1737 P-------IPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECP 1794

  Fly  1853 -----NQWVRLTEDVELIGRVP-----------ASSYAED------------------------- 1876
                 |..:.:.||::.....|           |.||..|                         
Human  1795 VGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNI 1859

  Fly  1877 ----MAIDPDTGAIYVIGGWDGSSTHSHVTKITLPDDICQLWSNGKYQCRHYMGCSYCTIQNTY- 1936
                ..|| ..|:.|.: ...|..|:...| :.|..:.|:..:.|...||:.:|...|...:.: 
Human  1860 CSHGQCID-TVGSFYCL-CHTGFKTNDDQT-MCLDINECERDACGNGTCRNTIGSFNCRCNHGFI 1921

  Fly  1937 -SYSSHCFSHGRTPCANHNGTLVVNNGAACDDDWMASRNCSSFATCGACLAAWPTHQEVAP---V 1997
             |:::.|.....  ||:.||.|       |       ||.....|.|:.........||||   .
Human  1922 LSHNNDCIDVDE--CASGNGNL-------C-------RNGQCINTVGSFQCQCNEGYEVAPDGRT 1970

  Fly  1998 CHWCDDCGIRGR-CVPA---GVDCGRRSAWCNKELSVGVLGLCPLPQCYQL---SCE---SCMLQ 2052
            |...::|.:..| |.|.   .:|...|               |..|..|.|   .||   .|:.:
Human  1971 CVDINECLLEPRKCAPGTCQNLDGSYR---------------CICPPGYSLQNEKCEDIDECVEE 2020

  Fly  2053 PQ------CNWARNELGTVECIAKE--LVEKNQYRVVESCPLPCHTYENCSLCLSQTPTQDH--Q 2107
            |:      |:   |..|:.:|:..|  .:..:..|..:.....|:.......| |...:::|  |
Human  2021 PEICALGTCS---NTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKC-SSPKSRNHSKQ 2081

  Fly  2108 EC-------KWSTMLNLCLTPSSQPL--LCAGGVCGLVL----EASELQRCPEP--CHVYTQC-- 2155
            ||       .|.....||.|...:..  :|..| .|:::    .|.::..|.||  |. :.||  
Human  2082 ECCCALKGEGWGDPCELCPTEPDEAFRQICPYG-SGIIVGPDDSAVDMDECKEPDVCK-HGQCIN 2144

  Fly  2156 -----------------SSCLEHAHC--------GWC----------AREGFNGDGICTEGALEH 2185
                             :.|::...|        |.|          ..|||....:.|...:..
Human  2145 TDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINE 2209

  Fly  2186 KQEHP--SGSTCDLIYASW----------RNDSQLTHADVVSWHYVQCPAENECINGHHNCDTVS 2238
            ..::|  ....|...|.|:          |.|.::            |..|:||..|.|:|....
Human  2210 CAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRM------------CKDEDECEEGKHDCTEKQ 2262

  Fly  2239 EQCIDLDTAVG-YKCVCAQGY-REEQGACLPVCSQGCVRGNCVSPDQCQCDFGYVGANCSIQCLC 2301
            .:|.:|   :| |.|:|..|| |...|       :|||..|     :||...|.           
Human  2263 MECKNL---IGTYMCICGPGYQRRPDG-------EGCVDEN-----ECQTKPGI----------- 2301

  Fly  2302 NGHSNCESSSRLDICLKCHNNTMGEQCEKCQPLFVGNPREGHACQPCLDYCHGHSDVCVAYDADP 2366
                 ||:..    ||    ||.|....:|...|..:|.:    ..|||...|:   |..     
Human  2302 -----CENGR----CL----NTRGSYTCECNDGFTASPNQ----DECLDNREGY---CFT----- 2341

  Fly  2367 AVFNMTRSELERILQEG-----PAYNATCLRCGNHTAGDRCDSCLTGYFRGSEDLHKECRPCQCH 2426
                   ..|:.:.|.|     |...:.|...|....|..|:.|   .|:|:....|.|.    |
Human  2342 -------EVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEIC---PFQGTVAFKKLCP----H 2392

  Fly  2427 GHGNICDPVTGEKC----------NCANNTES-DATCTAG-----GGKNSAQLCWMVQCSKCRDS 2475
            |.|.:.:....::|          .|.|:..| ...|..|     .|.:...|....|..|..:.
Human  2393 GRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNF 2457

  Fly  2476 YAGNPTDGHQCYKQ----ITVESRMCFDAKPIEECKSK 2509
            ...|....:||...    :..:.|.|   |.::||.:|
Human  2458 ICKNTEGSYQCSCPKGYILQEDGRSC---KDLDECATK 2492

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Megf8NP_609180.3 CUB 33..141 CDD:238001 537/2963 (18%)
NanM <210..455 CDD:442289 48/366 (13%)
KELCH repeat 228..268 CDD:276965 2/39 (5%)
KELCH repeat 370..420 CDD:276965 10/69 (14%)
KELCH repeat 425..476 CDD:276965 9/50 (18%)
NanM 431..>630 CDD:442289 36/220 (16%)
KELCH repeat 480..540 CDD:276965 8/71 (11%)
EGF_3 1186..1222 CDD:463759 19/35 (54%)
EGF_Lam 1257..1302 CDD:238012 13/46 (28%)
EGF_Lam 1304..1354 CDD:238012 18/54 (33%)
KELCH repeat 1585..1638 CDD:276965 10/53 (19%)
NanM 1596..1892 CDD:442289 52/399 (13%)
KELCH repeat 1642..1685 CDD:276965 5/51 (10%)
KELCH repeat 1760..1813 CDD:276965 3/52 (6%)
KELCH repeat 1817..1867 CDD:276965 10/80 (13%)
EGF_Lam 2299..2346 CDD:238012 10/46 (22%)
EGF_Lam 2422..2487 CDD:238012 15/80 (19%)
FBN1NP_000129.3 EGF_CA 910..940 CDD:429571 7/37 (19%)
TB 966..1008 CDD:459903 9/41 (22%)
EGF_CA 1070..1104 CDD:214542 8/38 (21%)
EGF_CA 1113..1149 CDD:214542 5/35 (14%)
EGF_CA 1155..1188 CDD:214542 7/32 (22%)
vWFA <1194..1235 CDD:469594 7/47 (15%)
EGF_3 1326..1361 CDD:463759 19/35 (54%)
EGF_3 1367..1402 CDD:463759 13/38 (34%)
EGF_CA 1446..1486 CDD:214542 18/75 (24%)
EGF_CA 1487..1518 CDD:214542 14/127 (11%)
TB 1549..1589 CDD:459903 11/71 (15%)
EGF_CA 1606..1638 CDD:214542 5/52 (10%)
EGF_CA 1648..1687 CDD:214542 7/38 (18%)
TB 1705..1748 CDD:459903 11/112 (10%)
EGF_CA 1766..1796 CDD:429571 3/29 (10%)
EGF_CA 1808..1840 CDD:214542 6/31 (19%)
vWFA <1847..1886 CDD:469594 6/40 (15%)
EGF_CA 1930..1972 CDD:214542 14/57 (25%)
EGF_CA 1973..2008 CDD:238011 10/49 (20%)
EGF_CA 2013..2043 CDD:429571 6/32 (19%)
TB 2068..2111 CDD:459903 10/43 (23%)
EGF_CA 2127..2165 CDD:214542 6/38 (16%)
EGF_CA 2166..2205 CDD:214542 7/38 (18%)
vWFA <2289..2328 CDD:469594 16/67 (24%)
TB <2357..2390 CDD:459903 9/35 (26%)
vWFA <2442..2482 CDD:469594 6/39 (15%)
EGF_CA 2485..2514 CDD:429571 3/8 (38%)
EGF_CA 2524..2566 CDD:214542
EGF_CA 2567..>2596 CDD:214542
EGF_CA 2607..2638 CDD:214542
Fibrillin_U_N 48..82 CDD:436338
TB 194..>227 CDD:459903 5/59 (8%)
EGF_CA 246..>276 CDD:214542 1/29 (3%)
EGF_CA 288..329 CDD:214542 8/40 (20%)
TB 343..389 CDD:459903 6/45 (13%)
EGF_CA 490..521 CDD:214542 6/39 (15%)
EGF_CA 530..571 CDD:214542 4/40 (10%)
EGF_CA 572..612 CDD:214542 7/39 (18%)
EGF_CA 613..646 CDD:214542 6/36 (17%)
TB 668..711 CDD:459903 8/42 (19%)
EGF_CA 765..806 CDD:238011 11/48 (23%)
TB 860..>890 CDD:459903 6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

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