DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Megf8 and MEGF8

DIOPT Version :10

Sequence 1:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster
Sequence 2:NP_001258867.1 Gene:MEGF8 / 1954 HGNCID:3233 Length:2845 Species:Homo sapiens


Alignment Length:3097 Identity:1018/3097 - (32%)
Similarity:1413/3097 - (45%) Gaps:564/3097 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 STSPSA---PCDRSRKVFTEPYGEISDGPSGFNYTQDSHCEWLIKARNDSQYITLTFHSMGTECS 84
            |.||.|   .|...|:|..|..|.::||..  ||:.:.:|||||:|.:....|.|.|..:.|||:
Human    20 SLSPGARAGDCKGQRQVLREAPGFVTDGAG--NYSVNGNCEWLIEAPSPQHRILLDFLFLDTECT 82

  Fly    85 YDYIYVYDGDSFNSTLLGSFSGRTQPQRLVARSGSMLILMYSDTNYVLDGFRASYYISNCLNNCH 149
            |||::||||||....||.|.||.|:|..:.|.||.||:.::||.||.|.||.||:..|.|...|.
Human    83 YDYLFVYDGDSPRGPLLASLSGSTRPPPIEASSGKMLLHLFSDANYNLLGFNASFRFSLCPGGCQ 147

  Fly   150 NHGKCVGHQ----CVCHGEWVGPDCEDEACPQRCGESQGRGRCQKSI--CHCSRGYSGRLCDLS- 207
            :||:|   |    |.|...|.||||..:.|...||   ..|.|...:  |.|..|:.||.|||. 
Human   148 SHGQC---QPPGVCACEPGWGGPDCGLQECSAYCG---SHGTCASPLGPCRCEPGFLGRACDLHL 206

  Fly   208 -DHPAGSSWRWLATDAEGMTARAAHSAVYMEDEDALYVFGGYDLNNVISTLQIYRFSTSQWEDEW 271
             ::.....|..::......:||...:..::.....|.||||.||||.:..|.:|.||.:.||.  
Human   207 WENQGAGWWHNVSARDPAFSARIGAAGAFLSPPGLLAVFGGQDLNNALGDLVLYNFSANTWES-- 269

  Fly   272 GIALQSRRHFYHPQKIDHTLLKAVLQHKNEDEAKLWGLNSDVSFFRNILYTLAESNLHQRRTRSS 336
                                               |.|:.                         
Human   270 -----------------------------------WDLSP------------------------- 274

  Fly   337 LPLTIVNANSTDEELNEYLEDILEEVTDHKPHGRYGHAADSVPGGFVIYGGKHANGSFYSDLWQY 401
                                         .|..|:.|.|.:..|..|:.||:.|:||..:|:|.:
Human   275 -----------------------------APAARHSHVAVAWAGSLVLMGGELADGSLTNDVWAF 310

  Fly   402 NNTESGGKWKQMA--IRSAVKPPALARHTLNTAGS-YLYIFGGSLETGEFSSSVYRIPLPLSEDS 463
            :.. ..|.|:.:|  ..|:..||.||.|....... :||:.||......|||.::|..|..:...
Human   311 SPL-GRGHWELLAPPASSSSGPPGLAGHAAALVDDVWLYVSGGRTPHDLFSSGLFRFRLDSTSGG 374

  Fly   464 QWELVQPRGGKTLDVRLAAHSTVYYKATNSLIVFGGIMTSLARFSKLSDRIYAFQLDQMHWTEIL 528
            .||.|.|.||:  ......||.|::..:.:|:|.||...|.||||...:....|.:|:..|| .|
Human   375 YWEQVIPAGGR--PPAATGHSMVFHAPSRALLVHGGHRPSTARFSVRVNSTELFHVDRHVWT-TL 436

  Fly   529 YPRTALRDTNIPRERAFHTATISGNYMVVFGGYTHRHNKDEICYDNQMYWYHLSCHIWINQVVSA 593
            ..|..|:.   |||||||||::.||||||:||..|.|.::|.||::.:::|||.||.|::....|
Human   437 KGRDGLQG---PRERAFHTASVLGNYMVVYGGNVHTHYQEEKCYEDGIFFYHLGCHQWVSGAELA 498

  Fly   594 ----DDSLYPKPQGVFAHAAALRRNHTLLIVGGYHGNVNADLFAYELPQ-VLRVENTLYNPEISC 653
                .:.....|.|.::|.||:.....||:.|||.|....||.||::|. |.:.....|:.:. |
Human   499 PPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAGGYSGRPRGDLMAYKVPPFVFQAPAPDYHLDY-C 562

  Fly   654 RLHSSHTACLSNPECGWCSADSSCY-----GRTIGANCTTNLQTTRCPGICPSLGDCHSCLVHGS 713
            .:::.|:.|..:|||.||  ..:|.     |..:|| |    ....|.|:...||||.:||    
Human   563 SMYTDHSVCSRDPECSWC--QGACQAAPPPGTPLGA-C----PAASCLGLGRLLGDCQACL---- 616

  Fly   714 QWGKSSGNKAAFS--VASKLGLNECTWCVQNAKCHHRDDNYGICGD----SSGWWGDKGTEIRRP 772
                      |||  .|...|.....|||.|..|..|.:.....|:    :.||||.....:...
Human   617 ----------AFSSPTAPPRGPGTLGWCVHNESCLPRPEQARCRGEQISGTVGWWGPAPVFVTSL 671

  Fly   773 SLCTSTDRRPGLTYIKYHFPINYTMPDYVGIVNATMVDFASPPFTTYFEHKLEGEMLARLVGFVR 837
            ..|.:....|||..:.:..|.|.:.||.|.||.:|.:.. :|...|      :..::.|  ||:.
Human   672 EACVTQSFLPGLHLLTFQQPPNTSQPDKVSIVRSTTITL-TPSAET------DVSLVYR--GFIY 727

  Fly   838 PQHQWNNSAIQVCTSYSSAVLRAGLGLNLDELVNVTTQSSNQSYCSNV-QLPTTEQPFTI----- 896
            |                  :|..|.|....|.|.|.|::......:.: :.|.||....:     
Human   728 P------------------MLPGGPGGPGAEDVAVWTRAQRLHVLARMARGPDTENMEEVGRWVA 774

  Fly   897 --DFQTRR--RIGGNGIY---NAYQKTKMELQHLHNGQLNA-----------------------F 931
              :.:|||  |.|...::   ....|..:|:|    ||||.                       .
Human   775 HQEKETRRLQRPGSARLFPLPGRDHKYAVEIQ----GQLNGSAGPGHSELTLLWDRTGVPGGSEI 835

  Fly   932 TFEYLEPYYSGKCTQYSNCLHCLTDASCAWCPLTNICHLRSVNETEVCKMETLDTFHWSYLISQP 996
            :|.:||||.|..||.||:||.||.|..|.||..:..||||.....  |..   |....|.|:..|
Human   836 SFFFLEPYRSSSCTSYSSCLGCLADQGCGWCLTSATCHLRQGGAH--CGD---DGAGGSLLVLVP 895

  Fly   997 SQCSNCTNYVSCEACARSGECEWWTE-----DARCGRIGKTNSSVRAVEHCPRSCRERHGCQECL 1056
            :.|..|..:..|.||.:...|||...     ||.|.|.|:...::::.|.||..|.:|..|::||
Human   896 TLCPLCEEHRDCHACTQDPFCEWHQSTSRKGDAACSRRGRGRGALKSPEECPPLCSQRLTCEDCL 960

  Fly  1057 GERGRCVWCEASAQCFSFSVYTSEYQFGMCREWVDQVVSRQTQEIADHKPQQTPHFLQQQCKSCE 1121
            ....:|.||:::..||.|:.|.:.|..|.||.|.|.|.|                  :.:|:||:
Human   961 ANSSQCAWCQSTHTCFLFAAYLARYPHGGCRGWDDSVHS------------------EPRCRSCD 1007

  Fly  1122 QHRNCSSCLRTLSCGWCFDRDNPIEGICMQGDFS--YSAGNCSL----ALNSSSHHDAEWAYAQC 1180
            ....|..||::..||||.:.|||..|.|:|||||  ...|||||    .|.......|.||||:|
Human  1008 GFLTCHECLQSHECGWCGNEDNPTLGRCLQGDFSGPLGGGNCSLWVGEGLGLPVALPARWAYARC 1072

  Fly  1181 PDVDECGLGLHDCHKEAKCTNTQGSYNCHCRRGYIGDGKFSCVRTCYELCQNGNCSGPPDYTCRC 1245
            ||||||.|||..||..|.|.||..||.|||:|||.|||...|.|||.|.|.:|.||||||:||.|
Human  1073 PDVDECRLGLARCHPRATCLNTPLSYECHCQRGYQGDGISHCNRTCLEDCGHGVCSGPPDFTCVC 1137

  Fly  1246 ALGWT-------------GADCGLSCGCNNHSTCNER-LGKCDQCQDWSEGEKCERCRQGSYGNA 1296
            .||||             ...|...|||:.||.|.:| .|.||:||||:.||.|||||.||:|||
Human  1138 DLGWTSDLPPPTPAPGPPAPRCSRDCGCSFHSHCRKRGPGFCDECQDWTWGEHCERCRPGSFGNA 1202

  Fly  1297 TAPHGCLPCECNGHGNQDLGVCNVSNGECYCKDNTQGLNCELCAPGYYGDPRGGGKCYYQCESRG 1361
            |...||.||:|||||:...|.|:..:|.|:|:|:|:|.:|:||:||||||||.||.|:.:|..|.
Human  1203 TGSRGCRPCQCNGHGDPRRGHCDNLSGLCFCQDHTEGAHCQLCSPGYYGDPRAGGSCFRECGGRA 1267

  Fly  1362 ILTNIGKSAIGSYQ--SYRSPWGASLE----VKECLWI------LQPKTLQAEKSLLQLEFQWQS 1414
            :|||:...|:||.:  ....|.|.:..    :..|:|:      |||.........|.|.|...|
Human  1268 LLTNVSSVALGSRRVGGLLPPGGGAARAGPGLSYCVWVVSATEELQPCAPGTLCPPLTLTFSPDS 1332

  Fly  1415 LAMDCDENAVYIYDSLPDL--TGATQQNQ-LLAVVCAP-YSSPRIIEARSSHVTVHYK-QGSERR 1474
             :..|..:.|..:|..|..  ||..|.:: |:|..|.. ...|..::|.|..:.:|:: .||.  
Human  1333 -STPCTLSYVLAFDGFPRFLDTGVVQSDRSLIAAFCGQRRDRPLTVQALSGLLVLHWEANGSS-- 1394

  Fly  1475 HFGFNALYSVMNCVA---GSCISPHICDAQQ------RCVCPAGYVGASCEIEICPSNCNAKRMQ 1530
            .:||||......|.:   |||..|..|..|.      .|.||.|:.|..|.:.:||.||||....
Human  1395 SWGFNASVGSARCGSGGPGSCPVPQECVPQDGAAGAGLCRCPQGWAGPHCRMALCPENCNAHTGA 1459

  Fly  1531 GFCDTEYGRCICSNANYAGADCGTLVQRNHLVMTELFNTQLLSESLEHLRKTIPRFGHSVNADRR 1595
            |.|:...|.|||:. .:.|.||.|.:....||...|.:::|   |.:...:.:.|.||::.....
Human  1460 GTCNQSLGVCICAE-GFGGPDCATKLDGGQLVWETLMDSRL---SADTASRFLHRLGHTMVDGPD 1520

  Fly  1596 GSLWMFGGYSPNHGPLNDFRQFDTKNSTWLQVT--VESSTPEDRMPLGRYFHASEIYVK--KQII 1656
            .:||||||.....|.|.:..::......|.|:.  .|...|.   |..|.|||: .||.  :..:
Human  1521 ATLWMFGGLGLPQGLLGNLYRYSVSERRWTQMLAGAEDGGPG---PSPRSFHAA-AYVPAGRGAM 1581

  Fly  1657 YIYGGIGANSQLLNDFWMFSIQNQRWSQIKVEVEPPEADYEVDVPPPLAGHTLTHIRYQEHESLI 1721
            |:.||:.|.. :..|||:.::...:|.|.|       |...|:: |.:||||||..|   ..||:
Human  1582 YLLGGLTAGG-VTRDFWVLNLTTLQWRQEK-------APQTVEL-PAVAGHTLTARR---GLSLL 1634

  Fly  1722 LLGGLSLNKSRPLELWEFNLDTGRWQQLAAVGARMPVLYGHTSVYHQETNSVYLFGGYS-----T 1781
            |:||.|.......:|.|:.|.||.|...|..|.....||||::|||:.|:|:|:|||:.     .
Human  1635 LVGGYSPENGFNQQLLEYQLATGTWVSGAQSGTPPTGLYGHSAVYHEATDSLYVFGGFRFHVELA 1699

  Fly  1782 EPQSNLYALDLQKLSWTEL-PS------------------------------FRELN-------- 1807
            .|...||:|.....:|:.| ||                              |||:.        
Human  1700 APSPELYSLHCPDRTWSLLAPSQGAKRDRMRNVRGSSRGLGQVPGEQPGSWGFREVRKKMALWAA 1764

  Fly  1808 -----------SPASLLPRARYFHSAVTTEHYMILYGGRTQPFNGTDVLIAYVYACNQWV--RLT 1859
                       ||....||.|.||::......|::.|||:.|...:..::.|...||.|:  .||
Human  1765 LAGTGGFLEEISPHLKEPRPRLFHASALLGDTMVVLGGRSDPDEFSSDVLLYQVNCNAWLLPDLT 1829

  Fly  1860 EDVELIGRVPASSYAEDMAIDPDTGA-IYVIGGWDGSSTHSHVTKITLPDDICQLWSNGKYQCRH 1923
            .... :|.....|.|..:|.   .|: :|:.||:.|.:. ..:..:|||.|.|:|.|:.: .|..
Human  1830 RSAS-VGPPMEESVAHAVAA---VGSRLYISGGFGGVAL-GRLLALTLPPDPCRLLSSPE-ACNQ 1888

  Fly  1924 YMGCSYCTIQNTYSYSSHCFSHG---------RTPCANHNGTLVVNNGAACDDDWMASRNCSSFA 1979
            ...|::|              ||         |..|          .|:.|.....:...|....
Human  1889 SGACTWC--------------HGACLSGDQAHRLGC----------GGSPCSPMPRSPEECRRLR 1929

  Fly  1980 TCGACLAAWP------THQEVAPVCHWCDDCGIRGRCVPAGVDCGRRSAWCNKELSVGV------ 2032
            ||..|||..|      ..:...|.|.||.:|       |.|...||..: |..|....:      
Human  1930 TCSECLARHPRTLQPGDGEASTPRCKWCTNC-------PEGACIGRNGS-CTSENDCRINQREVF 1986

  Fly  2033 -LGLCPLPQCYQLSCESCMLQPQCNWARNELGTVE--------------CIAKELVEKNQYRVVE 2082
             .|.|....|....||.|..:.:|.|.|....|.|              |.:..|:..:...|..
Human  1987 WAGNCSEAACGAADCEQCTREGKCMWTRQFKRTGETRRILSVQPTYDWTCFSHSLLNVSPMPVES 2051

  Fly  2083 S----CPLPCHTYENCSLCL-SQTPTQDHQECKWSTMLNLCLTPSSQPLLCAGGVCGLVLEASEL 2142
            |    ||.|||...||:.|| |:......|.|.||:.|..||:||..||.|..|.||.:|...| 
Human  2052 SPPLPCPTPCHLLPNCTSCLDSKGADGGWQHCVWSSSLQQCLSPSYLPLRCMAGGCGRLLRGPE- 2115

  Fly  2143 QRCPEPCHVYTQCSSCLEHAHCGWCAREGFNGDGICTEGALEHKQEHPSGSTCDLIYASWRNDSQ 2207
             .|...|...|||:.||...||||||..|.:|.|.|.||.|...::   |.||....|||.    
Human  2116 -SCSLGCAQATQCALCLRRPHCGWCAWGGQDGGGRCMEGGLSGPRD---GLTCGRPGASWA---- 2172

  Fly  2208 LTHADVVSWHYVQCPAENECINGHHNCDTVSEQCIDLDTAVGYKCVCAQGYREEQ--GACLPVCS 2270
                      ::.||.|:||.||||:|:. ::.|  .|...||:|.|..||..:.  |.|.|||:
Human  2173 ----------FLSCPPEDECANGHHDCNE-TQNC--HDQPHGYECSCKTGYTMDNMTGLCRPVCA 2224

  Fly  2271 QGCVRGNCVSPDQCQCDFGYVGANCSIQCLCNGHSNCESSSRLDICLKCHNNTMGEQCEKCQPLF 2335
            ||||.|:||.||.|:|.||:||.|||.:|.||.||.|......|.||.|.|:|.|..||:|.|||
Human  2225 QGCVNGSCVEPDHCRCHFGFVGRNCSTECRCNRHSECAGVGARDHCLLCRNHTKGSHCEQCLPLF 2289

  Fly  2336 VGNPREGHACQPCLDYCHGHSDVCVA------YDADPAVFNMTRSELERILQEGPAYN-ATCLRC 2393
            ||:...|..|:||..:|.|:|.:|::      ...:|..:::...|:|..:.|||:.: |.|:.|
Human  2290 VGSAVGGGTCRPCHAFCRGNSHICISRKELQMSKGEPKKYSLDPEEIENWVTEGPSEDEAVCVNC 2354

  Fly  2394 GNHTAGDRCDSCLTGYFRGSEDLHKECRPCQCHGHGNICDPVTGEKCNCANNTESDATCTAGGGK 2458
            .|::.|::|:|||.|||.    |..:|..|||:||.:.|:...|..|.|.||||: .|| .|...
Human  2355 QNNSYGEKCESCLQGYFL----LDGKCTKCQCNGHADTCNEQDGTGCPCQNNTET-GTC-QGSSP 2413

  Fly  2459 NSAQLCWMVQCSKCRDSYAGNPTDGHQCYKQITVESRMCFDAKPIEECKSKP--AALKPGQTVFF 2521
            :..:.|:..||:|||:|:.|:|..|.|||:.|:||...|.|......|..:|  .||.||:||.|
Human  2414 SDRRDCYKYQCAKCRESFHGSPLGGQQCYRLISVEQECCLDPTSQTNCFHEPKRRALGPGRTVLF 2478

  Fly  2522 VIQPRFMNVDIRIIIDVTQGELDVFMSPQDDSFIVETNETTGYHEIFLDNRYNWGPKIKREHPLN 2586
            .:||:|.|||||:.:|||.|.:|:::|...|:|:|.....||.|.:.:.     .|......|  
Human  2479 GVQPKFTNVDIRLTLDVTFGAVDLYVSTSYDTFVVRVAPDTGVHTVHIQ-----PPPAPPPPP-- 2536

  Fly  2587 VALPRHDNVTIQKLFSPERRIGGGGLGGGGGERIGANTYYVPQLQDCKSHGGHNFIVKDQHAKDL 2651
               |..|.       .|.    |.|..||.|...|......|::::....|             |
Human  2537 ---PPADG-------GPR----GAGDPGGAGASSGPGAPAEPRVREVWPRG-------------L 2574

  Fly  2652 STHVTLNHCNTLLRLFGLKNRLVLTLPQHAHNLSATRFFIAL--------RASSGPEPSYGSVVF 2708
            .|:||:...:.:|.:.|:::|||:|.|...|.|.::||::.|        ..::|...|.|.:.|
Human  2575 ITYVTVTEPSAVLVVRGVRDRLVITYPHEHHALKSSRFYLLLLGVGDPSGPGANGSADSQGLLFF 2639

  Fly  2709 RQDQLHIDLFVFFSVFFSCFFLFLAVCVIVWKVKQAADLRRARRQHVVEMLHLAKRPFAQIFLAS 2773
            ||||.|||||||||||||||||||::||::||.|||.|.|:.:|:|:.||..:|.||||::.:..
Human  2640 RQDQAHIDLFVFFSVFFSCFFLFLSLCVLLWKAKQALDQRQEQRRHLQEMTKMASRPFAKVTVCF 2704

  Fly  2774 NGLDMDSPQPTSSSSSAR-------AMRQRARQALLLQEQSAGDSQSVMHHS-------TRRQSS 2824
                  .|.||:.:|:.:       |.|:.......|....||.....|...       ......
Human  2705 ------PPDPTAPASAWKPAGLPPPAFRRSEPFLAPLLLTGAGGPWGPMGGGCCPPAIPATTAGL 2763

  Fly  2825 RIMMVAIEPTFDNLAAVGTVFISLPGRSRAPLSIALGSTLIS 2866
            |...:.:|||.|.:|.|.|:.:.|||...||....|||.|::
Human  2764 RAGPITLEPTEDGMAGVATLLLQLPGGPHAPNGACLGSALVT 2805

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Megf8NP_609180.3 CUB 33..141 CDD:238001 50/107 (47%)
NanM <210..455 CDD:442289 49/247 (20%)
KELCH repeat 228..268 CDD:276965 14/39 (36%)
KELCH repeat 370..420 CDD:276965 16/51 (31%)
KELCH repeat 425..476 CDD:276965 17/51 (33%)
NanM 431..>630 CDD:442289 74/203 (36%)
KELCH repeat 480..540 CDD:276965 19/59 (32%)
EGF_3 1186..1222 CDD:463759 21/35 (60%)
EGF_Lam 1257..1302 CDD:238012 27/45 (60%)
EGF_Lam 1304..1354 CDD:238012 28/49 (57%)
KELCH repeat 1585..1638 CDD:276965 15/54 (28%)
NanM 1596..1892 CDD:442289 102/357 (29%)
KELCH repeat 1642..1685 CDD:276965 14/44 (32%)
KELCH repeat 1760..1813 CDD:276965 25/107 (23%)
KELCH repeat 1817..1867 CDD:276965 14/51 (27%)
EGF_Lam 2299..2346 CDD:238012 22/46 (48%)
EGF_Lam 2422..2487 CDD:238012 27/64 (42%)
MEGF8NP_001258867.1 CUB 49..139 CDD:238001 44/91 (48%)
NanM 227..531 CDD:442289 111/401 (28%)
KELCH repeat 228..275 CDD:276965 18/137 (13%)
Kelch 1 241..287 21/136 (15%)
KELCH repeat 279..331 CDD:276965 16/52 (31%)
Kelch 2 290..338 16/48 (33%)
Kelch 3 346..399 18/54 (33%)
Kelch 4 402..453 23/54 (43%)
KELCH repeat 448..510 CDD:276965 26/61 (43%)
Kelch 5 459..511 18/51 (35%)
Kelch 6 525..575 16/50 (32%)
PSI 950..998 CDD:396154 18/47 (38%)
EGF_3 1078..1112 CDD:463759 21/33 (64%)
EGF_Lam 1210..1259 CDD:238012 28/48 (58%)
Kelch 7 1522..1570 15/50 (30%)
NanM 1557..1858 CDD:442289 91/320 (28%)
KELCH repeat 1566..1612 CDD:276965 16/54 (30%)
Kelch 8 1580..1626 17/54 (31%)
KELCH repeat 1620..1669 CDD:276965 21/51 (41%)
Kelch 9 1632..1679 18/46 (39%)
KELCH repeat 1672..1720 CDD:276965 19/47 (40%)
Kelch 10 1685..1735 13/49 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1726..1745 0/18 (0%)
KELCH repeat 1785..1838 CDD:276965 15/53 (28%)
Kelch 11 1796..1843 13/47 (28%)
Kelch 12 1852..1898 15/61 (25%)
EGF_CA 2180..2214 CDD:238011 15/36 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2523..2564 11/61 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2817..2845
Blue background indicates that the domain is not in the aligned region.

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