Protein Alignment Megf8 and dsd

DIOPT Version :10

• Sequence 1: NP_609180.3
• Gene: Megf8 / 34099
• FlyBaseID: FBgn0031981
• Length: 2892
• Species: Drosophila melanogaster
• Sequence 2: XP_309653.6
• Gene: dsd / 1270925
• VectorBaseID: AGAMI1_014526
• Length: 1317
• Species: Anopheles gambiae
• Alignment Length: 1742
• Identity: 381/1742 - (21%)
• Similarity: 565/1742 - (32%)
• Gaps: 621/1742 - (35%)

  Fly  1288 CRQG------SYGNA--TAPHGCLPCEC-NGHGNQDLGVCNVSNGECYCKDNTQGLNCELCAPGY 1343
            |..|      |:|.|  ..|..|....| ||      |||  .||.|.|.|..||..|:.|
Mosquito    55 CHLGPTVLVSSHGLAGVADPGKCSEVRCMNG------GVC--KNGTCLCPDGWQGSECQFC---- 107

  Fly  1344 YGDPRGGGKCYYQCESRGILTNIGKSAIGSYQSYRSPWGASLEVKECLWILQPK----------T 1398
                  |||......|..|...:|..:||              || |.|::..:          |
Mosquito   108 ------GGKVRLTEPSGSIHDGLGNYSIG--------------VK-CSWLIDAREHNSITDKVST 151

  Fly  1399 LQAEKSLLQLEFQWQSLAMDCDENAVYIYDSLPDLTGATQQNQLLAVVCA-----PYSSPRIIE- 1457
            .....|:::|..  :..|.:|..:.:|:||      |.:.::.||||...     .::..||.|
Mosquito   152 EPGRPSVIRLHL--EEFATECGWDHLYVYD------GDSVESPLLAVFSGLMYRKNFTIRRIPEV 208

  Fly  1458 -ARSSHVTVHYKQGSERRHFGFNALY---------SVMNCVA-GSCISPHICDAQQRCVCPAGYV 1511
             |.|....:|:.........|||..|         |::||.. |.|.:       ..|.|.:|:.
Mosquito   209 FAHSGSALLHFFSDDAYNMSGFNISYQVNACPTNDSLLNCSGNGDCWN-------GECSCNSGFT 266

  Fly  1512 GASCEIEICPSNCNAKRMQGFCDTEYGRCICSNANYAGADCGTLVQRNHLVMTELFNTQLLSE-- 1574
            ||:|.:..||:.|:|...:|.||.:..||:|| |.|.|.||...:...:....:...|:..:.
Mosquito   267 GAACNVPRCPNYCSAHLGRGVCDRKQQRCVCS-AGYTGNDCSQAIAHGYWTAIDAGETEGFTPPG 330

  Fly  1575 SLEHLRKTIPRFGHSVNADRRGSLWMFGGYSPNHGPLND-FRQFDTKNSTWLQVTVESSTPEDR- 1637
            |..|        |.:|..|   :|::..|.|  :|.... ...:|.....|     |::..|.|
Mosquito   331 SASH--------GAAVFHD---TLYVIAGES--YGKAEALLYMYDFNGKVW-----ETAHTESRP 377

  Fly  1638 MPLGRYFHASEIYVKKQIIYIYGGIGANSQLLNDFWMFSIQNQRWSQIKVEVEPPEADYEVDVPP 1702
            .|..||..::.|:..|  |::|||:.....:..:.|.|.:..:.|..|.|:.|.....||:..|.
Mosquito   378 APELRYGASTVIFGDK--IFMYGGVIEGRGVCGELWAFDVSAKIWENITVKAEQCNDTYEMCGPL 440

  Fly  1703 PLAGHTLTHI-RY-QEHESLILLGGLSLNKSRPL-----------ELWEFNLDTGRWQQLAAVGA 1754
            ..||||.|.: .| |.....:|.||.|..|...:           .:.|||..|..|:.:...|.
Mosquito   441 RSAGHTATIVSNYDQVGGKKVLTGGGSSQKMVVIFGHSPQFGYLNTVQEFNFGTREWRIVPTRGY 505

  Fly  1755 RMPVLYGHTSVYHQETNSVYLFGGYSTEPQSN------LYALDLQKLSWTELPSFRELNSPASLL 1813
            .:...|||::.|......:|::||..:|..|:      ||:.:..:..||.|.:          .
Mosquito   506 PVKGGYGHSAAYDPLRERIYVYGGIVSESDSSQLLSNKLYSYEPHERLWTLLET----------A 560

  Fly  1814 PRARYFHSA-VTTEHYMILYGGRTQPFNGTD----------VLIAYVYACNQWVRLTEDVELIGR 1867
            |.||:.|:| ..|...|:::||.|.  |.|.          .|:.|...|:.|....
Mosquito   561 PTARFLHTANFLTPGLMMVFGGNTH--NDTSHSFGAKCYSRDLMVYDVLCDSWHAQP-------- 615

  Fly  1868 VPASSYAEDMAIDPDTG-----AIYVIGGWDGSSTHSHVTKITLPDDICQLWSNGKYQC---RHY 1924
            :|...|| |:|....:.     ::||.||:||...:. :.:.| |.| ||.: |...||   |..
Mosquito   616 MPDDLYA-DLARFGHSAVVFERSLYVYGGFDGQMVND-MLQFT-PGD-CQAF-NRTDQCLNARPG 675

  Fly  1925 MGCSYCTIQNTYSYSSHCF--------------SHGRTPCANHNGTLVVNNGAACDDDWMASRNC 1975
            :.|.: .||     .|.|.              ..|...|...:..::..:      :.|....|
Mosquito   676 VKCVW-DIQ-----KSRCLPAAAVQRERLFDRDQEGLEVCPKKSRLVMTQH------ELMDYELC 728

  Fly  1976 SSFATCGACLAAWPTHQEVAPVCHWCDDCGI---RGRCV----PAGVDCGRRSAWCNKELSVGVL 2033
            |...||..|::          ..:.|..|||   :|.||    |......|...:..|.|..
Mosquito   729 SQLTTCQGCVS----------TAYGCMFCGIGNGKGICVKEKCPDVSYTYRADFYPTKALKD--- 780

  Fly  2034 GLCPLPQ---CYQL-SCESCMLQPQCNW---------ARNELGTVECIAKELVEKNQYRVVESCP 2085
              ||...   |.|| .|.:|.....|:|         :||:.|..              :.::||
Mosquito   781 --CPDNDEHVCAQLHGCHACTAVSVCHWDYEHSRCQYSRNKSGDA--------------LNDACP 829

  Fly  2086 LPCHTYENCSLCLSQTPTQDHQECKWSTMLNLCLTPSSQPLLCAGGVCGLVLEASELQRC----P 2146
            ..|....:|..|     ||  :||.|......|:..::.......|.|......|...|.    .
Mosquito   830 PACSGLTSCGNC-----TQ--EECIWCQNEQRCVDKNAYTASFPYGQCREWTTGSSKCRAASSGK 887

  Fly  2147 EPCHVYTQCSSCLEHAHCGWCAREGFNGDGICTEGALEHKQEHPSGSTCDLIYASWRNDSQLTHA 2211
            ..|..|..|:.|.:...||||......|.|.|..|......|.   |.|
Mosquito   888 SQCGFYRTCAQCRDDPACGWCDDGSLTGLGKCLPGGDSGAHEE---SEC---------------- 933

  Fly  2212 DVVSWHYVQCPAENECINGHHNCDTVSEQCIDLDTAVGYKCVCAQGYREEQGACLPVCSQGCVRG 2276
            ....||:..||:
Mosquito   934 PAQRWHFTHCPS----------------------------------------------------- 945

  Fly  2277 NCVSPDQCQCDFGYVGANCSIQCLCNGHSNCESSSRLDICLK-CHNNTMGEQCEKCQPLFVGNPR 2340
                                  |.|||||.|..:.   .|.: |.|.|.|..|:||:|.|.|||.
Mosquito   946 ----------------------CQCNGHSTCPDAK---TCKQPCSNLTFGPNCDKCKPGFWGNPV 985

  Fly  2341 EGHACQPC-----LDYCHGHSDVCVAYDADPAVFNMTRSELERILQEGPAYNATCLRCGNHTAGD 2400
            .|..||.|     ..|||..:..|         |..|:.                      .|||
Mosquito   986 NGGICQKCECNGQAQYCHSETGKC---------FCSTKG----------------------LAGD 1019

  Fly  2401 RCDSCLTGYFRGSEDLHKECRPCQCHGHGNICDPVTGEKCNCANNTESDATCTAGGGKNSAQLCW 2465
            .|                                   |||:..|:
Mosquito  1020 HC-----------------------------------EKCDATNH-------------------- 1029

  Fly  2466 MVQCSKCRDSYAGNPTDGHQCYKQITVESRMCFDAKPIE-----ECKSKPAALKPGQTVFFVIQ- 2524
                      |.|:|:.| .||..:|::.:..|:....|     :...:.:.:||.....|.|.
Mosquito  1030 ----------YHGDPSRG-SCYYDLTIDYQFTFNLSKKEDRHFTQINFRNSPVKPDIDADFTITC 1083

  Fly  2525 --PRFMNVDIRIIIDVTQG--ELDVFMSPQDDSFIVETNETTGYHEIFLDNRYNWGPKIKREHPL 2585
              ...||:.||     |.|  |..:|.:....:|                 ||.:.   |.||..
Mosquito  1084 SVAARMNITIR-----TAGGIEKPLFSAVNCSTF-----------------RYRFS---KAEHQF 1123

  Fly  2586 NVALPRHDNVTIQKLFSPERRIGGGGLGGGGGERIGANTYYVPQLQDCKSHGGHNFIVKDQHAKD 2650
            .|    .||||:                         .|:||                   :..|
Mosquito  1124 GV----EDNVTL-------------------------TTFYV-------------------YVYD 1140

  Fly  2651 LSTHVTLNHCNTLLRLFGLKNRLVLTLPQHAHNLSATRFFIALRASSGPEPSYGSVVFRQDQLHI 2715
            ..                                               .|.:..:.|.| ...:
Mosquito  1141 FQ-----------------------------------------------PPLWIQIAFSQ-YPKL 1157

  Fly  2716 DLFVFFSVFFSCFFLFLAVCVIVWKVKQAADLRRARRQHVVEMLHLAKRPFAQIFLASNGLDMDS 2780
            :|..||..|.:||.|.|.:..|:||:||..|:.|.|::..|||..:|.|||:|:.:.....:.:.
Mosquito  1158 NLQQFFITFSTCFLLLLVMAAILWKIKQHYDMFRRRQRLFVEMEQMASRPFSQVLVEIESREYNE 1222

  Fly  2781 PQPTSSSSSARAMRQRARQALLLQEQSAGDSQSVMHHSTRRQSSRIMMVAIEPTFDNLAAVGTVF 2845
            ..|...:.:| |.|:|.:           ||.|              .:|:||...|.|||.::.
Mosquito  1223 LSPAVENITA-APRKRKK-----------DSPS--------------PIALEPCEGNRAAVLSLL 1261

  Fly  2846 ISLP--GRSRAP----LSIALGSTLISYSRQYPLNTRHFMRAQRGQNVANHP 2891
            :.||  |...:|    ..:|:.|.|::.......:..|....:..:..:.||
Mosquito  1262 VRLPTGGLQHSPPGQSAGLAVASALVTLGNPRRSSIEHPKEPKTKRKQSQHP 1313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Megf8	NP_609180.3	CUB	33..141	CDD:238001
		NanM	<210..455	CDD:442289
		KELCH repeat	228..268	CDD:276965
		KELCH repeat	370..420	CDD:276965
		KELCH repeat	425..476	CDD:276965
		NanM	431..>630	CDD:442289
		KELCH repeat	480..540	CDD:276965
		EGF_3	1186..1222	CDD:463759
		EGF_Lam	1257..1302	CDD:238012	6/21 (29%)
		EGF_Lam	1304..1354	CDD:238012	18/50 (36%)
		KELCH repeat	1585..1638	CDD:276965	12/54 (22%)
		NanM	1596..1892	CDD:442289	83/332 (25%)
		KELCH repeat	1642..1685	CDD:276965	11/42 (26%)
		KELCH repeat	1760..1813	CDD:276965	14/58 (24%)
		KELCH repeat	1817..1867	CDD:276965	14/60 (23%)
		EGF_Lam	2299..2346	CDD:238012	21/47 (45%)
		EGF_Lam	2422..2487	CDD:238012	8/64 (13%)
dsd	XP_309653.6	None