DRSC/TRiP Functional Genomics Resources

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Protein Alignment Megf8 and Megf8

DIOPT Version :10

Sequence 1:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster
Sequence 2:NP_446080.1 Gene:Megf8 / 114029 RGDID:621190 Length:2789 Species:Rattus norvegicus


Alignment Length:3019 Identity:1002/3019 - (33%)
Similarity:1394/3019 - (46%) Gaps:481/3019 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 CDRSRKVFTEPYGEISDGPSGFNYTQDSHCEWLIKARNDSQYITLTFHSMGTECSYDYIYVYDGD 94
            |...|:|..|..|.::||..  ||:.:.:|||||:|.:....|.|.|..:.|||:|||::|||||
  Rat    30 CKGQRQVLREAPGFVTDGAG--NYSVNGNCEWLIEAPSPQHRILLDFLFLDTECTYDYLFVYDGD 92

  Fly    95 SFNSTLLGSFSGRTQPQRLVARSGSMLILMYSDTNYVLDGFRASYYISNCLNNCHNHGKCVG-HQ 158
            |....||.|.||.|:|..:.|.||.||:.::||.||.|.||.||:..|.|...|.|||:|.. ..
  Rat    93 SPQGPLLASLSGSTRPPPIEASSGKMLLHLFSDANYNLLGFNASFRFSLCPGGCQNHGQCKSPGV 157

  Fly   159 CVCHGEWVGPDCEDEACPQRCGESQGRGRCQKSI--CHCSRGYSGRLCDLS--DHPAGSSWRWLA 219
            |||...|.||||..:.|...||   ..|.|..::  |.|..|:.||.|||.  ::.....|..::
  Rat   158 CVCEPGWGGPDCGLQECSAYCG---SHGTCASTLGPCRCEPGFLGRACDLHLWENQGAGWWHSVS 219

  Fly   220 TDAEGMTARAAHSAVYMEDEDALYVFGGYDLNNVISTLQIYRFSTSQWEDEWGIALQSRRHFYHP 284
            ......:||...:..::.....|.||||.|||..:..|.:|.|||:.||.               
  Rat   220 AGDPAFSARVGAAGAFLSPPGLLAVFGGQDLNKALGDLVLYNFSTNTWES--------------- 269

  Fly   285 QKIDHTLLKAVLQHKNEDEAKLWGLNSDVSFFRNILYTLAESNLHQRRTRSSLPLTIVNANSTDE 349
                                  |.|..                                      
  Rat   270 ----------------------WDLTP-------------------------------------- 274

  Fly   350 ELNEYLEDILEEVTDHKPHGRYGHAADSVPGGFVIYGGKHANGSFYSDLWQYNNTESGGKWKQMA 414
                            .|..|:.|.|.:..|..|:.||:.|||...:|:|.::.. .||.|:.:|
  Rat   275 ----------------APAARHSHVAVAWAGFLVLMGGELANGLLTNDVWAFSPL-GGGHWELLA 322

  Fly   415 --IRSAVKPPALARHTLNTAGS-YLYIFGGSLETGEFSSSVYRIPLPLSEDSQWELVQPRGGKTL 476
              ..|:..||.||.|....... :||:.||..:...|||.::|..|..:....||.|.|.||:  
  Rat   323 PPASSSSGPPGLAGHAAALVDDIWLYVSGGRTQHDLFSSGLFRFRLDHTSRGYWEQVIPAGGR-- 385

  Fly   477 DVRLAAHSTVYYKATNSLIVFGGIMTSLARFSKLSDRIYAFQLDQMHWTEILYPRTALRDTNIPR 541
            ......||.|::..:.:|:|.||...|.||||...:....|.:|:..|| .|..|..|:.   ||
  Rat   386 PPAATGHSMVFHAPSRTLLVHGGHRPSTARFSVRVNSTELFHVDRRVWT-TLKGRDGLQG---PR 446

  Fly   542 ERAFHTATISGNYMVVFGGYTHRHNKDEICYDNQMYWYHLSCHIWINQVVSA----DDSLYPKPQ 602
            |||||||::.||||||:||..|.|.::|.||::.:::|||.||.|::....|    .:.....|.
  Rat   447 ERAFHTASVLGNYMVVYGGNVHTHYQEEKCYEDGIFFYHLGCHQWVSGAELAPPGTPEGRAAPPS 511

  Fly   603 GVFAHAAALRRNHTLLIVGGYHGNVNADLFAYELPQ-VLRVENTLYNPEISCRLHSSHTACLSNP 666
            |.::|.||:.....||:.|||.|....||.||::|. |.:.....|:.:. |.:::.|:.|..:|
  Rat   512 GRYSHVAAVLGGSVLLVAGGYSGRPRGDLMAYKVPPFVFQAPALDYHLDY-CSMYTDHSVCSRDP 575

  Fly   667 ECGWCSADSSCY-----GRTIGANCTTNLQTTRCPGICPSLGDCHSCLVHGSQWGKSSGNKAAFS 726
            ||.||  ..:|.     |...|| |    ....|.|:...|.||.:||              |||
  Rat   576 ECSWC--QGACQSAPPPGTPSGA-C----PAASCLGLGRLLSDCQACL--------------AFS 619

  Fly   727 --VASKLGLNECTWCVQNAKCHHRDDNYGICGD----SSGWWGDKGTEIRRPSLCTSTDRRPGLT 785
              .|...|.....|||.|..|..|.:.....|:    :.||||.....:.....|.:....|||.
  Rat   620 SPTAPPRGPGTLGWCVHNESCLPRPEQARCRGEQISGTVGWWGPAPVFVTSLEACVTQSFLPGLH 684

  Fly   786 YIKYHFPINYTMPDYVGIVNATMVDFASPPFTTYFEHKLEGEMLARLVGFVRPQHQW-------N 843
            .:.:..|.|.:.||.|.||.:|.:.. :|...|      :..::.|  ||:.|....       .
  Rat   685 LLTFQQPPNASQPDKVSIVRSTTITL-TPSAET------DVSLVYR--GFIYPMLPGGPGGPGAE 740

  Fly   844 NSAIQVCTSYSSAVLRAGLG---LNLDELVNVTTQSSNQSYCSNVQLPTTEQPFTIDFQTRRRIG 905
            :.|:.........:.|...|   .|::|:.....|...::  ..:|.|.:.:.|.:.        
  Rat   741 DVAVWARAQRLHVLARMARGPDTENMEEVGRWVAQQEKET--RRLQRPGSSRLFPLP-------- 795

  Fly   906 GNGIYNAYQKTKMELQHLHNGQLNA-----------------------FTFEYLEPYYSGKCTQY 947
            |.|     .|..:|::    ||||.                       .:|.:||||.|..|:.|
  Rat   796 GRG-----NKYAVEIR----GQLNGSAGPGHSELTLLWDRTGVPGGSEISFFFLEPYRSLACSSY 851

  Fly   948 SNCLHCLTDASCAWCPLTNICHLRSVNETEVCKMETLDTFHWSYLISQPSQCSNCTNYVSCEACA 1012
            |:||.||.|..|.||..:..||||.....  |:.   |....|.|:..|:.|..|..:..|.||.
  Rat   852 SSCLGCLADQGCGWCLNSATCHLRQGRAH--CED---DGNGESLLVLVPALCPLCEEHRDCHACT 911

  Fly  1013 RSGECEWWTE-----DARCGRIGKTNSSVRAVEHCPRSCRERHGCQECLGERGRCVWCEASAQCF 1072
            :...|||...     ||.|.|.|:...:::..|.||..|.:|..|::||....:|.||:::..||
  Rat   912 QDPFCEWHQSTNRKGDAACSRRGRGRGALKNPEECPPLCSQRLTCEDCLANSSQCAWCQSTHTCF 976

  Fly  1073 SFSVYTSEYQFGMCREWVDQVVSRQTQEIADHKPQQTPHFLQQQCKSCEQHRNCSSCLRTLSCGW 1137
            .|:.|.:.|..|.||.|.|.|.|                  :.:|:||.....|..||::..|||
  Rat   977 LFAAYLARYPHGGCRGWDDSVHS------------------EPRCRSCHGFLTCHECLQSHECGW 1023

  Fly  1138 CFDRDNPIEGICMQGDFS--YSAGNCSL----ALNSSSHHDAEWAYAQCPDVDECGLGLHDCHKE 1196
            |.:.|||..|.|:|||||  ...|||||    .|.......|.||||:|||||||.|||..||..
  Rat  1024 CGNEDNPTLGRCLQGDFSGPLGGGNCSLWVGEGLGLPVALPARWAYARCPDVDECRLGLARCHPR 1088

  Fly  1197 AKCTNTQGSYNCHCRRGYIGDGKFSCVRTCYELCQNGNCSGPPDYTCRCALGWT----------- 1250
            |.|.||..||.|||:|||.|||...|.|||.|.|.:|.||||||:||.|.||||           
  Rat  1089 ATCLNTPLSYECHCQRGYQGDGITHCNRTCLEDCGHGVCSGPPDFTCVCDLGWTSDLPPPTPAPG 1153

  Fly  1251 --GADCGLSCGCNNHSTCNER-LGKCDQCQDWSEGEKCERCRQGSYGNATAPHGCLPCECNGHGN 1312
              ...|...||||.||.|..| .|.||:||||:.||.|||||.||:||||...||.||:|||||:
  Rat  1154 PPAPRCSRDCGCNFHSHCRRRGPGYCDECQDWTWGEHCERCRPGSFGNATGSGGCRPCQCNGHGD 1218

  Fly  1313 QDLGVCNVSNGECYCKDNTQGLNCELCAPGYYGDPRGGGKCYYQCESRGILTNIGKSAIGS--YQ 1375
            ...|.|:..:|.|:|:|:|:|.:|::|:||||||||.||.|:.:|..|.:|||:...|:||  :.
  Rat  1219 PRRGHCDNLSGLCFCQDHTEGAHCQICSPGYYGDPRAGGSCFRECGGRALLTNVSSVALGSRRFG 1283

  Fly  1376 SYRSPWGASLE----VKECLWI------LQPKTLQAEKSLLQLEFQWQSLAMDCDENAVYIYDSL 1430
            ....|.|.:..    :..|:|:      |||.........|.|.|...| :..|..:.|..:|..
  Rat  1284 GLLPPGGGTARAGPGLSYCVWVVSATEALQPCAPGTLCPPLTLTFSPDS-STPCTLSYVLAFDGF 1347

  Fly  1431 PDL--TGATQQNQ-LLAVVCAP-YSSPRIIEARSSHVTVHYK-QGSERRHFGFNALYSVMNCVA- 1489
            |..  ||..|.:: |:|..|.. ...|..::|.|..:.:|:: .||.  .:||||......|.: 
  Rat  1348 PRFLDTGVVQSDRSLIAAFCGQRRDRPLTVQALSGLLVLHWEANGSS--SWGFNASVGSARCGSG 1410

  Fly  1490 --GSCISPHICDAQQ------RCVCPAGYVGASCEIEICPSNCNAKRMQGFCDTEYGRCICSNAN 1546
              |||..|..|..|.      .|.||.|:.|..|.:.:||.||||....|.|:...|.|||:. .
  Rat  1411 GPGSCPVPQECVPQDGAAGAGLCRCPQGWAGPHCRMALCPENCNAHTGAGICNQSLGVCICAE-G 1474

  Fly  1547 YAGADCGTLVQRNHLVMTELFNTQLLSESLEHLRKTIPRFGHSVNADRRGSLWMFGGYSPNHGPL 1611
            :.|.||.|.:....||...|.:::|   |.:...:.:.|.||::......:||||||.....|.|
  Rat  1475 FGGPDCATKLDGGQLVWETLMDSRL---SADTASRFLHRLGHTMVEGPDATLWMFGGLGLPQGLL 1536

  Fly  1612 NDFRQFDTKNSTWLQVT--VESSTPEDRMPLGRYFHASEIYVK--KQIIYIYGGIGANSQLLNDF 1672
            .:..::......|.|:.  .|...|.   |..|.|||: .||.  :..:|:.||:.|.. :..||
  Rat  1537 GNLYRYSVSERRWTQMLAGAEDGGPG---PSPRSFHAA-AYVPAGRGAMYLLGGLTAGG-ITCDF 1596

  Fly  1673 WMFSIQNQRWSQIKVEVEPPEADYEVDVPPPLAGHTLTHIRYQEHESLILLGGLSLNKSRPLELW 1737
            |:.::...:|.|.|       |...::: |.:||||||..|   ..||:|:||.|.......:|.
  Rat  1597 WVLNLTTLQWRQEK-------APQSIEL-PAVAGHTLTARR---GLSLLLVGGYSPENGFNQQLL 1650

  Fly  1738 EFNLDTGRWQQLAAVGARMPVLYGHTSVYHQETNSVYLFGGYS-----TEPQSNLYALDLQKLSW 1797
            |:.|.||.|...|..|.....||||::|||:.|:|:|:|||:.     ..|...||:|.....:|
  Rat  1651 EYQLATGTWVSGAQSGTPPTGLYGHSAVYHEATDSLYVFGGFRFHVELAAPSPELYSLHCPDRTW 1715

  Fly  1798 TEL-PSFRELNSPASLLPRARYFHSAVTTEHYMILYGGRTQPFNGTDVLIAYVYACNQWVRLTED 1861
            :.| ||       ....||.|.||::......|::.|||:.|...:..::.|...||.|  |..|
  Rat  1716 SLLAPS-------QGAKPRPRLFHASALLGDTMVVLGGRSDPDEFSSDVLLYQVNCNTW--LLPD 1771

  Fly  1862 V---ELIGRVPASSYAEDMAIDPDTGA-IYVIGGWDGSSTHSHVTKITLPDDICQLWSNGKYQCR 1922
            :   ..:|.....|.|..:|.   .|: :|:.||:.|.:. ..:..:|||.|.|:|..:.: .|.
  Rat  1772 LTRPAFVGSPMEESVAHAVAA---VGSRLYISGGFGGVAL-GRLLALTLPPDPCRLLPSPE-ACN 1831

  Fly  1923 HYMGCSYCTIQNTYSYSSHCFSHGRTPCANHNGTLVVNNGAACDDDWMASRNCSSFATCGACLAA 1987
            ....|::|.........:|....|..||:...               .:...|....||..|||.
  Rat  1832 QSGACTWCHGACLSGDQAHRLGCGVPPCSPMP---------------RSPEECRRLRTCSECLAR 1881

  Fly  1988 WP------THQEVAPVCHWCDDCGIRGRCVPAGVDCGRRSAWCNKELSVGV-------LGLCPLP 2039
            .|      ..:...|.|.||.:|       |.|...||..: |..|....:       .|.|...
  Rat  1882 HPRTLQPGDGEASVPRCKWCTNC-------PEGACIGRNGS-CTSENDCRINQREVFWAGNCSEA 1938

  Fly  2040 QCYQLSCESCMLQPQCNWARNELGTVE--------------CIAKELVEKNQYRVVES----CPL 2086
            .|....||.|..:.:|.|.|....|.|              |.:..|:..:...|..|    ||.
  Rat  1939 ACGAADCEQCTREGKCMWTRQFKRTGETRRILSVQPTYDWTCFSHSLLNVSPMPVESSPPLPCPT 2003

  Fly  2087 PCHTYENCSLCL-SQTPTQDHQECKWSTMLNLCLTPSSQPLLCAGGVCGLVLEASELQRCPEPCH 2150
            |||...||:.|| |:......|.|.||:.|..||:||..||.|..|.||.:|...|  .|...|.
  Rat  2004 PCHLLPNCTSCLASKGADGGWQHCVWSSSLQQCLSPSYLPLRCMAGGCGRLLRGPE--SCSLGCA 2066

  Fly  2151 VYTQCSSCLEHAHCGWCAREGFNGDGICTEGALEHKQEHPSGSTCDLIYASWRNDSQLTHADVVS 2215
            ..|||:.||...||||||..|.:|.|.|.||.|...::   |.||....|||.            
  Rat  2067 QATQCALCLRRPHCGWCAWGGQDGGGHCMEGGLSGPRD---GLTCGRPGASWA------------ 2116

  Fly  2216 WHYVQCPAENECINGHHNCDTVSEQCIDLDTAVGYKCVCAQGYREEQ--GACLPVCSQGCVRGNC 2278
              ::.||.|:||.||||:|:. ::.|  .|...||:|.|..||..:.  |.|.|||:||||.|:|
  Rat  2117 --FLSCPPEDECANGHHDCNE-TQNC--HDQPHGYECSCKTGYTMDNVTGVCRPVCAQGCVNGSC 2176

  Fly  2279 VSPDQCQCDFGYVGANCSIQCLCNGHSNCESSSRLDICLKCHNNTMGEQCEKCQPLFVGNPREGH 2343
            |.||.|:|.||:||.|||.:|.||.||.|......|.||.|.|:|.|..||:|.|||||:...|.
  Rat  2177 VEPDHCRCHFGFVGRNCSTECRCNRHSECAGVGARDHCLLCRNHTKGSHCEQCLPLFVGSALGGG 2241

  Fly  2344 ACQPCLDYCHGHSDVCVAYD------ADPAVFNMTRSELERILQEGPAYN-ATCLRCGNHTAGDR 2401
            .|:||..:|.|:|.|||:..      .:|..:::...|:|..:.|||:.: |.|:.|.|::.|||
  Rat  2242 TCRPCHAFCRGNSHVCVSRKELEMARREPEKYSLDPEEIEAWVAEGPSEDEAVCVNCQNNSYGDR 2306

  Fly  2402 CDSCLTGYFRGSEDLHKECRPCQCHGHGNICDPVTGEKCNCANNTESDATCTAGGGKNSAQLCWM 2466
            |:|||.|||.    |..:|..|||:||.:.|:...|..|.|.||||: ..| .|...:..:.|:.
  Rat  2307 CESCLHGYFL----LDGKCTKCQCNGHADTCNEQDGTGCPCQNNTET-GVC-QGSSPSDRRDCYK 2365

  Fly  2467 VQCSKCRDSYAGNPTDGHQCYKQITVESRMCFDAKPIEECKSKP--AALKPGQTVFFVIQPRFMN 2529
            .||:|||:|:.|:|..|.|||:.|:||...|.|......|..:|  .||.||:||.|.:||:|.|
  Rat  2366 YQCAKCRESFHGSPLGGQQCYRLISVEQECCLDPTSQTNCFHEPKRRALGPGRTVLFGVQPKFTN 2430

  Fly  2530 VDIRIIIDVTQGELDVFMSPQDDSFIVETNETTGYHEIFLDNRYNWGPKIKREHPLNVALPRHDN 2594
            ||||:.:|||.|.:|:::|...|:|:|.....||.|.:          .|:...|.....|..|.
  Rat  2431 VDIRLTLDVTFGAVDLYVSTSYDTFVVRVAPDTGVHTV----------HIQPPPPPPPPPPPADG 2485

  Fly  2595 VTIQKLFSPERRIGGGGLGGGGGERIGANTYYVPQLQDCKSHGGHNFIVKDQHAKDLSTHVTLNH 2659
            |  .::.|.   :||.|.|.|.|..:      .|::::....|             |.|:||:..
  Rat  2486 V--PRVASD---LGGLGTGSGSGSPV------EPRVREVWPRG-------------LITYVTVTE 2526

  Fly  2660 CNTLLRLFGLKNRLVLTLPQHAHNLSATRFFIAL--------RASSGPEPSYGSVVFRQDQLHID 2716
            .:.:|.:..:::|||:|.|...|.|.::||::.|        ..::|...|.|.:.|||||.|||
  Rat  2527 PSAVLVVRSVRDRLVITYPHEHHALKSSRFYLLLLGVGDPNGPGANGSADSQGLLFFRQDQAHID 2591

  Fly  2717 LFVFFSVFFSCFFLFLAVCVIVWKVKQAADLRRARRQHVVEMLHLAKRPFAQIFLASNGLDMDSP 2781
            ||||||||||||||||::||::||.|||.|.|:.:|:|:.||..:|.||||::.:.... |...|
  Rat  2592 LFVFFSVFFSCFFLFLSLCVLLWKAKQALDQRQEQRRHLQEMTKMASRPFAKVTVCFPP-DPAGP 2655

  Fly  2782 QPTSSSSSARAMRQRARQALL--LQEQSAGDSQSVMHHS-------TRRQSSRIMMVAIEPTFDN 2837
            .|....:.......|..:..|  |....||.....|...       ......|...:.:|||.|.
  Rat  2656 APAWKPAGLPPPAFRRSEPFLAPLLLTGAGGPWGPMGGGCCPPALPATTAGLRAGPITLEPTEDG 2720

  Fly  2838 LAAVGTVFISLPGRSRAPLSIALGSTLIS 2866
            :|.|.|:.:.|||...||....|||.|::
  Rat  2721 MAGVATLLLQLPGGPHAPNGACLGSALVT 2749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Megf8NP_609180.3 CUB 33..141 CDD:238001 50/107 (47%)
NanM <210..455 CDD:442289 50/247 (20%)
KELCH repeat 228..268 CDD:276965 14/39 (36%)
KELCH repeat 370..420 CDD:276965 17/51 (33%)
KELCH repeat 425..476 CDD:276965 17/51 (33%)
NanM 431..>630 CDD:442289 74/203 (36%)
KELCH repeat 480..540 CDD:276965 19/59 (32%)
EGF_3 1186..1222 CDD:463759 21/35 (60%)
EGF_Lam 1257..1302 CDD:238012 28/45 (62%)
EGF_Lam 1304..1354 CDD:238012 27/49 (55%)
KELCH repeat 1585..1638 CDD:276965 15/54 (28%)
NanM 1596..1892 CDD:442289 96/309 (31%)
KELCH repeat 1642..1685 CDD:276965 14/44 (32%)
KELCH repeat 1760..1813 CDD:276965 20/58 (34%)
KELCH repeat 1817..1867 CDD:276965 14/52 (27%)
EGF_Lam 2299..2346 CDD:238012 22/46 (48%)
EGF_Lam 2422..2487 CDD:238012 26/64 (41%)
Megf8NP_446080.1 CUB 49..139 CDD:238001 43/89 (48%)
NanM 227..531 CDD:442289 74/306 (24%)
KELCH repeat 228..275 CDD:276965 16/46 (35%)
Kelch 1 241..287 15/45 (33%)
KELCH repeat 279..331 CDD:276965 2/51 (4%)
Kelch 2 290..338 2/47 (4%)
Kelch 3 346..399 12/52 (23%)
Kelch 4 402..453 17/53 (32%)
KELCH repeat 448..510 CDD:276965 23/61 (38%)
Kelch 5 459..511 18/51 (35%)
Kelch 6 525..575 26/49 (53%)
PSI 950..998 CDD:396154 17/47 (36%)
EGF_3 1078..1112 CDD:463759 8/33 (24%)
EGF_Lam 1163..1209 CDD:238012 25/49 (51%)
EGF_Lam 1210..1259 CDD:238012 28/61 (46%)
Kelch 7 1522..1570 17/47 (36%)
NanM 1540..1802 CDD:442289 86/271 (32%)
KELCH repeat 1566..1617 CDD:276965 14/50 (28%)
Kelch 8 1580..1626 12/45 (27%)
KELCH repeat 1621..1668 CDD:276965 15/50 (30%)
KELCH repeat 1673..1721 CDD:276965 14/47 (30%)
Kelch 10 1685..1735 16/49 (33%)
KELCH repeat 1729..1773 CDD:276965 16/43 (37%)
Kelch 11 1740..1787 20/51 (39%)
Kelch 12 1796..1841 14/45 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2466..2508 18/41 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2762..2789 8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

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