DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cka and Strn4

DIOPT Version :9

Sequence 1:	NP_001245936.1	Gene:	Cka / 34096	FlyBaseID:	FBgn0044323	Length:	749	Species:	Drosophila melanogaster
Sequence 2:	NP_598550.2	Gene:	Strn4 / 97387	MGIID:	2142346	Length:	760	Species:	Mus musculus

Alignment Length:	765	Identity:	343/765 - (44%)
Similarity:	453/765 - (59%)	Gaps:	128/765 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 GMGNVGGDDGGNGMVGGGVNNQQATTPQYTIPGILHFIQHEWSRFELERSQWDVDRAELQARIAM 133
            |.|.||...||.|..|     ..|.....::|||||||||||:|||.|:::|:.:||||||::|.
Mouse    40 GPGPVGKGGGGGGSPG-----PTAGPEPLSLPGILHFIQHEWARFEAEKARWEAERAELQAQVAF 99

  Fly   134 LLGERKCLESLKSDLTRRIKMLEYALRQERAKFYRLKYGTDPPQLNEFKPSNEDAGLAGEVATD- 197
            |.||||..|:||:||.||||||||||:|||||:::||:|||   ||:           ||..||
Mouse   100 LQGERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTD---LNQ-----------GEKKTDL 150

  Fly   198 ----SEVPYSSV----SNTTWRQGRQMLRQYLAEIGYTDNIIDVRSNRVRSILGLNNNAEHDGSG 254
                |..|..||    |...|::|||:|||||.|:||||.|:|:||.||||:||  .:.|.:|:|
Mouse   151 SEQVSNGPVESVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVRSLLG--RSLELNGAG 213

  Fly   255 GGLGG------GLGGGTGGENL-----SPNINGNESNKRASETEG-------------------- 288
            ..:.|      |.||.:|||:|     ...|..|.:.|...|..|
Mouse   214 EPVEGAPRASPGPGGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGSVLEQIPFLQNCEDEDSDE 278

  Fly   289 -------RH------TPAKK-VQQSIDEIIVDTEAAVMANFEFLGATEMSDDDEISDDLEMVATD 339
                   :|      .|:|. |.:..||...|.....:..|:|||:.|   |.|.|.|.....::
Mouse   279 DDELDSVQHKKQRVRLPSKALVPEMEDEDEEDDSEDAINEFDFLGSGE---DGEGSPDPRRCTSE 340

  Fly   340 NDDTDVKLAKRAKSGKDMLTEDLEADVGE-------------------------QLLNDMNLMTE 379
            .:..::: ::|.|      .:.:.||:.:                         ...:|:.:|..
Mouse   341 GNPHELE-SRRVK------LQGILADLRDVDGLPPKVTVPPPGTPQPRPHEGSFGFSSDVFIMDT 398

  Fly   380 EVDGSLGLGELAQLTVNNESDGAYD-ANSKDGTGGSAGGAGYRKTWNAKYTLRSHFDGVRSLIFH 443
            ...|.:.||:||.|||.|::|.:.| ::|||         .::||||.|:|||||:||:|||.||
Mouse   399 IGGGEVSLGDLADLTVTNDNDLSCDLSDSKD---------AFKKTWNPKFTLRSHYDGIRSLAFH 454

  Fly   444 PEEPVLITASEDHTLKLWNLQKTVQAKKSASLDVEPLYTFRAHTGPVLCLGMSSSGETCYSGGLD 508
            ..:..|:|||||.|||||||||.|.|||:|:|||||::.||||.||||.:.|.|:.|.|||||.|
Mouse   455 HSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVTMGSNSEYCYSGGAD 519

  Fly   509 GNIECWQLPSPNIDPYDCYDPNVHSGTLEGHTDAVWGL--TTMQSNIVSCSADGTVKLWSPYNKE 571
            ..|..|::|..|:||||.|||:|.|..||||.||||||  :.....:.||||||||::|.|.:..
Mouse   520 ARIHSWKIPDLNMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSG 584

  Fly   572 P-LLRTYTASEAEGVPSSVDFVRNEVDHIVVAYNSAHCIVYDTETGKQVVRLEAAQEMSGNTGKF 635
            | .|.|:......|:|:||.|...|..|:|.::.|...::||.|.|..::.||:    .|::|..
Mouse   585 PSCLCTFPMDGEHGIPTSVAFTSTEPAHVVASFRSGDTVLYDLEAGSALLTLES----RGSSGPA 645

  Fly   636 -INKVVSHPTLPITITAHEDRHIRFWDNTSGTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSI 699
             ||:|||||:.|:|||||:||.|||.||.:|..||||||||:.||.||||.:|::|:|||||||:
Mouse   646 QINQVVSHPSQPLTITAHDDRGIRFLDNRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSL 710

  Fly   700 RLWNLDNKTCVQEITAHRKKFDESIFDVAFHATKPYIASAGADGLAKVFV 749
            |||:||||||||||||||||.:|:|..||.|.:|..|||||||.||||||
Mouse   711 RLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVFV 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cka	NP_001245936.1	Striatin	98..228	CDD:285445	76/138 (55%)
		WD40	427..>748	CDD:225201	187/324 (58%)
		WD40	429..748	CDD:238121	186/322 (58%)
		WD40 repeat	439..485	CDD:293791	30/45 (67%)
		WD40 repeat	491..538	CDD:293791	24/46 (52%)
		WD40 repeat	543..578	CDD:293791	17/37 (46%)
		WD40 repeat	587..629	CDD:293791	13/41 (32%)
		WD40 repeat	636..672	CDD:293791	24/35 (69%)
		WD40 repeat	678..717	CDD:293791	30/38 (79%)
		WD40 repeat	724..748	CDD:293791	15/23 (65%)
Strn4	NP_598550.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65		9/29 (31%)
		Striatin	64..189	CDD:285445	76/138 (55%)
		Caveolin-binding. /evidence=ECO:0000255	71..79		6/7 (86%)
		Calmodulin-binding. /evidence=ECO:0000255	165..182		8/16 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..233		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..346		16/76 (21%)
		WD40	423..>753	CDD:225201	190/342 (56%)
		WD40	437..759	CDD:238121	187/325 (58%)
		WD 1	443..482		26/38 (68%)
		WD40 repeat	450..496	CDD:293791	30/45 (67%)
		WD 2	496..535		20/38 (53%)
		WD40 repeat	502..549	CDD:293791	24/46 (52%)
		WD 3	549..588		19/38 (50%)
		WD40 repeat	554..594	CDD:293791	17/39 (44%)
		WD 4	595..635		13/39 (33%)
		WD40 repeat	601..637	CDD:293791	11/35 (31%)
		WD 5	642..681		23/38 (61%)
		WD40 repeat	647..683	CDD:293791	24/35 (69%)
		WD 6	684..723		28/38 (74%)
		WD40 repeat	689..728	CDD:293791	30/38 (79%)
		WD 7	730..759		17/28 (61%)
		WD40 repeat	735..759	CDD:293791	15/23 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835683
Domainoid	1	1.000	161	1.000	Domainoid score	I3989
eggNOG	1	0.900	-	-		E1_KOG0642
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55995
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001711
OrthoInspector	1	1.000	-	-		otm44127
orthoMCL	1	0.900	-	-		OOG6_101735
Panther	1	1.100	-	-	LDO	PTHR15653
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1258
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.710