DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cka and Strn3

DIOPT Version :9

Sequence 1:	NP_001245936.1	Gene:	Cka / 34096	FlyBaseID:	FBgn0044323	Length:	749	Species:	Drosophila melanogaster
Sequence 2:	XP_036013597.1	Gene:	Strn3 / 94186	MGIID:	2151064	Length:	853	Species:	Mus musculus

Alignment Length:	890	Identity:	388/890 - (43%)
Similarity:	497/890 - (55%)	Gaps:	221/890 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 NSLGGGGSGGLSISGLNAGGQNANVGGMGNVGGDDGGNGMVGGG-----------VNNQQATTPQ 96
            :.|.|||.||..:    |.......|..||:....|.||..|||           ...:.:...|
Mouse     2 DELAGGGGGGQGM----AAPPRPQQGPGGNLSLPPGANGAPGGGGPPAAEAAGPPAGPELSRPQQ 62

  Fly    97 YTIPGILHFIQHEWSRFELERSQWDVDRAELQARIAMLLGERKCLESLKSDLTRRIKMLEYALRQ 161
            ||||||||:|||||:|||:||:.|:|:|||||||||.|.||||..|:||.||.||||||||||:|
Mouse    63 YTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQ 127

  Fly   162 ERAKFYRLKYGTDPPQLNEFKPSNEDAGLAGEVATDSEVPYS-SVSNTTWRQGRQMLRQYLAEIG 225
            ||||:::|||||:..|.:...|:.|     .|...|.|.|.: ..|..||:||||:|||||.|:|
Mouse   128 ERAKYHKLKYGTELNQGDLKMPTFE-----SEETKDVEAPPAPQNSQLTWKQGRQLLRQYLQEVG 187

  Fly   226 YTDNIIDVRSNRVRSILGLNNNAEHDGSGGGLGGGLGGGTGGENLSPNINGNESNKRASE----- 285
            |||.|:||||.||||:|||:|:..:            |....:||...:||.||.|:..:
Mouse   188 YTDTILDVRSQRVRSLLGLSNSEPN------------GSVEAKNLEQILNGGESPKQKGQEIKRP 240

  Fly   286 -----------------TEGRHTPAKKVQQSIDEIIV------------------DTEAAVMANF 315
                             .|..:...:.:.:..|::.:                  |||.| :..|
Mouse   241 PGDVLETFNFLENADDSDEEENDMIEGIPEGKDKLRIHKHKIGNEGLAADLTDDPDTEEA-LKEF 304

  Fly   316 EFL-------GATE--------------------------------------------------- 322
            :||       ||.|
Mouse   305 DFLVTAEDGEGAGEARSSGDGTEWDLFKARIIHFYSYPSFNFRKKNKVSIIDSTSFLGIPASSLL 369

  Fly   323 --------------MSDDDEISDDLEMVATDNDDTDVKLA-------KRAKSGK----------- 355
                          :.|.|::|...|:.     |.|..|.       |:.:.||
Mouse   370 LLPISYKQYQTICCLPDKDDLSPTAEVW-----DVDQGLISKLKEQYKKERKGKKGVKRVNRTNL 429

  Fly   356 -DMLTEDLEAD---------------VGEQLLNDMNLMTEEVD--------------GS------ 384
             ||:| ||..|               ...::.:......||.:              ||
Mouse   430 CDMIT-DLGDDELPHIPSGIINQSRSASTRMADHEGARAEEAEPITFPSGGGKSFIMGSDDVLLS 493

  Fly   385 -LGLGELAQLTVNNESDGAYD--ANSKDGTGGSAGGAGYRKTWNAKYTLRSHFDGVRSLIFHPEE 446
             ||||:||.|||.|::|.:||  || ||         .:|||||.||||||||||||:|.|||.|
Mouse   494 VLGLGDLADLTVTNDADYSYDLPAN-KD---------AFRKTWNPKYTLRSHFDGVRALAFHPVE 548

  Fly   447 PVLITASEDHTLKLWNLQKTVQAKKSASLDVEPLYTFRAHTGPVLCLGMSSSGETCYSGGLDGNI 511
            |||:|||||||||||||||||.|||||||||||:||||||.||||.|.:||:||.|:|||:|..|
Mouse   549 PVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATI 613

  Fly   512 ECWQLPSPNIDPYDCYDPNVHSGTLEGHTDAVWGL--TTMQSNIVSCSADGTVKLWSPYNKEPLL 574
            :.|.:||||:||||.|:.||.:|||..||||||||  :.:::.::|||||||::||:|..|.|.:
Mouse   614 QWWNMPSPNVDPYDTYESNVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPQEKLPCV 678

  Fly   575 RTYTASEAEGVPSSVDFVRNEVDHIVVAYNSAHCIVYDTETGKQVVRLEAAQEMSGNTGKFINKV 639
            .||...:..|:|:||||:..:..|:|.::|:...::||.||.:.:|.|.:..:....:...||:|
Mouse   679 CTYNGDKEHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVMLSSQVDSGLQSSNHINRV 743

  Fly   640 VSHPTLPITITAHEDRHIRFWDNTSGTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNL 704
            |||||||:||||||||||:|:||.:|.::|||||||:.|||||||.:|:||:|||||||||||||
Mouse   744 VSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNL 808

  Fly   705 DNKTCVQEITAHRKKFDESIFDVAFHATKPYIASAGADGLAKVFV 749
            |:|||||||||||||.||||:|||||.:|.||||||||.||||||
Mouse   809 DSKTCVQEITAHRKKLDESIYDVAFHPSKAYIASAGADALAKVFV 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cka	NP_001245936.1	Striatin	98..228	CDD:285445	80/130 (62%)
		WD40	427..>748	CDD:225201	210/322 (65%)
		WD40	429..748	CDD:238121	208/320 (65%)
		WD40 repeat	439..485	CDD:293791	39/45 (87%)
		WD40 repeat	491..538	CDD:293791	27/46 (59%)
		WD40 repeat	543..578	CDD:293791	17/36 (47%)
		WD40 repeat	587..629	CDD:293791	13/41 (32%)
		WD40 repeat	636..672	CDD:293791	26/35 (74%)
		WD40 repeat	678..717	CDD:293791	33/38 (87%)
		WD40 repeat	724..748	CDD:293791	18/23 (78%)
Strn3	XP_036013597.1	Striatin	65..190	CDD:400507	79/129 (61%)
		WD40	531..852	CDD:238121	208/320 (65%)
		WD40 repeat	541..587	CDD:293791	39/45 (87%)
		WD40 repeat	593..631	CDD:293791	22/37 (59%)
		WD40 repeat	645..683	CDD:293791	18/37 (49%)
		WD40 repeat	691..727	CDD:293791	12/35 (34%)
		WD40 repeat	740..776	CDD:293791	26/35 (74%)
		WD40 repeat	782..821	CDD:293791	33/38 (87%)
		WD40 repeat	828..852	CDD:293791	18/23 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835685
Domainoid	1	1.000	161	1.000	Domainoid score	I3989
eggNOG	1	0.900	-	-		E1_KOG0642
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H82078
Inparanoid	1	1.050	709	1.000	Inparanoid score	I646
Isobase	1	0.950	-	1	Normalized mean entropy	S2945
OMA	1	1.010	-	-		QHG55995
OrthoDB	1	1.010	-	-		D194096at33208
OrthoFinder	1	1.000	-	-		FOG0001711
OrthoInspector	1	1.000	-	-		otm44127
orthoMCL	1	0.900	-	-		OOG6_101735
Panther	1	1.100	-	-	O	PTHR15653
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1845
SonicParanoid	1	1.000	-	-		X1258
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750