DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cka and strn

DIOPT Version :9

Sequence 1:	NP_001245936.1	Gene:	Cka / 34096	FlyBaseID:	FBgn0044323	Length:	749	Species:	Drosophila melanogaster
Sequence 2:	NP_001074111.1	Gene:	strn / 791160	ZFINID:	ZDB-GENE-070112-1172	Length:	782	Species:	Danio rerio

Alignment Length:	807	Identity:	369/807 - (45%)
Similarity:	472/807 - (58%)	Gaps:	185/807 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 GDDGGNGMVGGGVNNQQATTPQYTIPGILHFIQHEWSRFELERSQWDVDRAELQARIAMLLGERK 139
            ||.||           :|....|:|||||||:||||:||||||:||:|:||||||:||.|.||||
Zfish    29 GDGGG-----------EAARAHYSIPGILHFLQHEWARFELERAQWEVERAELQAQIAFLQGERK 82

  Fly   140 CLESLKSDLTRRIKMLEYALRQERAKFYRLKYGTDPPQLNEFKPSNEDAGLAGEVATDSEVPYSS 204
            ..|:||.||.||||||||||:||||||::|||||:..| .:.||.:.|:....|   :..:|..:
Zfish    83 GQENLKKDLVRRIKMLEYALKQERAKFHKLKYGTELNQ-GDMKPPSYDSDDGNE---NEALPEPA 143

  Fly   205 VSNTTWRQGRQMLRQYLAEIGYTDNIIDVRSNRVRSILGLNNNAEHDGSGGGLGGGLGGGTGGE- 268
            .|..:|:||||:|||||.|:||||.|:||:|.||:::|                 ||.|.|||:
Zfish   144 NSQLSWKQGRQLLRQYLQEVGYTDTILDVKSQRVKALL-----------------GLCGETGGDA 191

  Fly   269 NLSPNINGNESNKRASETEGRHTPAKKVQQSIDEIIVDTEAAVMANFEFL--GATEMSDDDE--- 328
            ...|.:||.|.   ||..:..||...|.:.|       ..|.|:..|:|:  .|.|.||::|
Zfish   192 RDEPMVNGTEP---ASLKDSTHTMIGKAEMS-------DSATVLEAFKFIEKAAAEFSDEEEDED 246

  Fly   329 -----------------------------ISDDL----------------EMVATDNDDT----- 343
                                         :|:||                :|:.....||
Zfish   247 SEGQNRSIVDLATMVRRKVSPSPSSSSTDVSEDLDTDEVLKGFDFLANTEDMMEGQTQDTPAAGD 311

  Fly   344 -------------DV------------KLAKRAKSG---------KDML-----TEDL------- 362
                         ||            |..::.|.|         :|||     .|||
Zfish   312 WEKEEQSPLCESWDVDEGLISKLKEQYKKERKGKKGVKRPNRCKLQDMLANLRDAEDLSSIQPPV 376

  Fly   363 ------------EADVGEQLLNDMNLMT--------------EEVDGSLGLGELAQLTVNNESDG 401
                        |..:|.  .:::..||              |.::..|||||||.|||.||::.
Zfish   377 APPARPSLPRLNEHQLGR--TDEVEAMTFPPSSGKSFIMGTDEALENELGLGELAGLTVANEAES 439

  Fly   402 -AYD-ANSKDGTGGSAGGAGYRKTWNAKYTLRSHFDGVRSLIFHPEEPVLITASEDHTLKLWNLQ 464
             :|| .|:||         ..|||||.|:|||:|||.:|.|.|||.||||||||||||||:||||
Zfish   440 LSYDITNNKD---------ALRKTWNPKFTLRNHFDSIRGLAFHPVEPVLITASEDHTLKMWNLQ 495

  Fly   465 KTVQAKKSASLDVEPLYTFRAHTGPVLCLGMSSSGETCYSGGLDGNIECWQLPSPNIDPYDCYDP 529
            ||...||.|:|||||:||||||.|||||:.||||||.|:||||||.|:.|..|:|||||||.|:.
Zfish   496 KTAPTKKCAALDVEPIYTFRAHRGPVLCVVMSSSGEQCFSGGLDGTIQSWNTPNPNIDPYDSYES 560

  Fly   530 NVHSGTLEGHTDAVWGL--TTMQSNIVSCSADGTVKLWSPYNKEPLLRTYTASEAEGVPSSVDFV 592
            :|..|:|.|||||||||  ::....::||||||||:|||..:.||.:..:..::..|||||||.|
Zfish   561 SVLRGSLSGHTDAVWGLVFSSAHQRLLSCSADGTVRLWSAADTEPAIACFNTNKELGVPSSVDVV 625

  Fly   593 RNEVDHIVVAYNSAHCIVYDTETGKQVVRLEAAQEMSGNTGKFINKVVSHPTLPITITAHEDRHI 657
            .::..|:|.|:::....:|:.||.:.::.||:......:....||||:|||||||||||.|||||
Zfish   626 CSDPAHMVTAFSNGRTGIYNMETRQLILELESQSAGKPDAPCQINKVLSHPTLPITITAQEDRHI 690

  Fly   658 RFWDNTSGTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNLDNKTCVQEITAHRKKFDE 722
            ||:||.:|.|:|||||||:.|||||||.:||||:|||||||:||||:::|||:||.|||||||||
Zfish   691 RFFDNNTGKLIHSMVAHLDAVTSLAVDPNGLYLMSGSHDCSVRLWNMESKTCIQEFTAHRKKFDE 755

  Fly   723 SIFDVAFHATKPYIASAGADGLAKVFV 749
            ||.|||||.:|.||.|||||.||||||
Zfish   756 SINDVAFHPSKCYIGSAGADALAKVFV 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cka	NP_001245936.1	Striatin	98..228	CDD:285445	79/129 (61%)
		WD40	427..>748	CDD:225201	203/322 (63%)
		WD40	429..748	CDD:238121	202/320 (63%)
		WD40 repeat	439..485	CDD:293791	35/45 (78%)
		WD40 repeat	491..538	CDD:293791	29/46 (63%)
		WD40 repeat	543..578	CDD:293791	17/36 (47%)
		WD40 repeat	587..629	CDD:293791	13/41 (32%)
		WD40 repeat	636..672	CDD:293791	28/35 (80%)
		WD40 repeat	678..717	CDD:293791	29/38 (76%)
		WD40 repeat	724..748	CDD:293791	17/23 (74%)
strn	NP_001074111.1	Striatin	41..167	CDD:285445	79/129 (61%)
		WD40	431..>775	CDD:225201	213/352 (61%)
		WD40	457..781	CDD:238121	203/323 (63%)
		WD40 repeat	471..516	CDD:293791	35/44 (80%)
		WD40 repeat	522..569	CDD:293791	29/46 (63%)
		WD40 repeat	574..613	CDD:293791	17/38 (45%)
		WD40 repeat	623..656	CDD:293791	8/32 (25%)
		WD40 repeat	669..705	CDD:293791	28/35 (80%)
		WD40 repeat	711..747	CDD:293791	27/35 (77%)
		WD40 repeat	757..781	CDD:293791	17/23 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579007
Domainoid	1	1.000	165	1.000	Domainoid score	I3874
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	664	1.000	Inparanoid score	I731
OMA	1	1.010	-	-		QHG55995
OrthoDB	1	1.010	-	-		D194096at33208
OrthoFinder	1	1.000	-	-		FOG0001711
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101735
Panther	1	1.100	-	-	O	PTHR15653
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910