DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cka and strn3

DIOPT Version :9

Sequence 1:	NP_001245936.1	Gene:	Cka / 34096	FlyBaseID:	FBgn0044323	Length:	749	Species:	Drosophila melanogaster
Sequence 2:	XP_031746409.1	Gene:	strn3 / 779917	XenbaseID:	XB-GENE-999798	Length:	784	Species:	Xenopus tropicalis

Alignment Length:	775	Identity:	378/775 - (48%)
Similarity:	471/775 - (60%)	Gaps:	150/775 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 PQYTIPGILHFIQHEWSRFELERSQWDVDRAELQARIAMLLGERKCLESLKSDLTRRIKMLEYAL 159
            ||||||||||:|||||:|||:||:.|:|::||||||||.|.||||..|:||.||.||||||||||
Frog    40 PQYTIPGILHYIQHEWARFEMERAHWEVEKAELQARIAFLQGERKGQENLKKDLVRRIKMLEYAL 104

  Fly   160 RQERAKFYRLKYGTDPPQLNEFKPSNEDAGLAGEVATDSEV-PYSSVSNTTWRQGRQMLRQYLAE 223
            :|||||:::|||||:..|.:...|:.|     .|...|||| |....|..||:||||:|||||.|
Frog   105 KQERAKYHKLKYGTELNQGDLKTPTFE-----SEETKDSEVSPGPQNSQLTWKQGRQLLRQYLQE 164

  Fly   224 IGYTDNIIDVRSNRVRSILGLNNNAEHDGSGGGLGGGLGGGTGGENLSPNINGNES--------- 279
            :||||.|:||||.||||:|||:            |....|....:||...:||.:|
Frog   165 VGYTDTILDVRSQRVRSLLGLS------------GSEPNGSVETKNLEQILNGGDSLSLKQKGQA 217

  Fly   280 NKRAS------------------ETEG---RHTPAKKVQQSID------------EIIVDTEAAV 311
            |||.|                  |.||   ...|.::.:|.::            |:..|||.|
Frog   218 NKRNSGDVLETFNFLESADDSDEEDEGDLIEDVPDRREKQQMNKKHKIGNEGLAAELADDTEEA- 281

  Fly   312 MANFEFL-------GATE---MSDDDEISDDLEMVATDNDDTD-----------------VKLAK 349
            :..|:||       ||.|   ..|..|...|:....|:..|.|                 .|.||
Frog   282 LKEFDFLVTAEDGEGAGEARSSGDGTEWEKDVLSPTTEVWDVDQGLINKLKEEYTKERKGTKGAK 346

  Fly   350 RAKSGKDMLTEDLEADVGEQLLNDMN--------------------------------------- 375
            |....|   ..|:.||:||:.|:.:.
Frog   347 RVNRTK---LHDMIADLGEEDLSHIPAEILSPARTPSSRITDHEGGRAEEGAEPFAYTEPIAFPP 408

  Fly   376 ------LMTEE--VDGSLGLGELAQLTVNNESDGAYD-ANSKDGTGGSAGGAGYRKTWNAKYTLR 431
                  :|..|  ::..||||:||.|||.|::|.:|| .::||         .:|||||.|||||
Frog   409 GSGKPFIMASEDVLESVLGLGDLADLTVTNDADFSYDIPSNKD---------AFRKTWNPKYTLR 464

  Fly   432 SHFDGVRSLIFHPEEPVLITASEDHTLKLWNLQKTVQAKKSASLDVEPLYTFRAHTGPVLCLGMS 496
            |||||||:|.|||.||||:|||||||||||||||||..||||||||||:||||||.||||.|.:.
Frog   465 SHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPTKKSASLDVEPIYTFRAHIGPVLSLVVG 529

  Fly   497 SSGETCYSGGLDGNIECWQLPSPNIDPYDCYDPNVHSGTLEGHTDAVWGL--TTMQSNIVSCSAD 559
            .|||.|||||||..|:.|::||||:||||.|||:|.:|||.|||||||||  :.::.:::|||||
Frog   530 CSGEHCYSGGLDSTIQWWKIPSPNVDPYDTYDPSVLAGTLVGHTDAVWGLSHSGVKDSLLSCSAD 594

  Fly   560 GTVKLWSPYNKEPLLRTYTASEAEGVPSSVDFVRNEVDHIVVAYNSAHCIVYDTETGKQVVRLEA 624
            |||:||||......:.||..:...|:|:||||:..:..|.|.::.|...:|||.||.:.|::|.:
Frog   595 GTVRLWSPPTGTQCIGTYNGNREHGIPTSVDFIGCDPAHAVASFTSGCIVVYDLETSESVIQLSS 659

  Fly   625 AQEMSGNTGKFINKVVSHPTLPITITAHEDRHIRFWDNTSGTLVHSMVAHLEPVTSLAVDAHGLY 689
            ..:........|||:|||||||:||.|.|||||:|:||.||..:|||||||:.|||||||.:|:|
Frog   660 PSDSGAPFSNHINKIVSHPTLPVTIAAFEDRHIKFFDNKSGKSIHSMVAHLDAVTSLAVDPNGIY 724

  Fly   690 LLSGSHDCSIRLWNLDNKTCVQEITAHRKKFDESIFDVAFHATKPYIASAGADGLAKVFV 749
            |:||||||||||||||:|||||||||||||.||||:|||||.:|.:|||||||.||||||
Frog   725 LMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHPSKAFIASAGADALAKVFV 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cka	NP_001245936.1	Striatin	98..228	CDD:285445	81/130 (62%)
		WD40	427..>748	CDD:225201	211/322 (66%)
		WD40	429..748	CDD:238121	209/320 (65%)
		WD40 repeat	439..485	CDD:293791	38/45 (84%)
		WD40 repeat	491..538	CDD:293791	29/46 (63%)
		WD40 repeat	543..578	CDD:293791	17/36 (47%)
		WD40 repeat	587..629	CDD:293791	14/41 (34%)
		WD40 repeat	636..672	CDD:293791	25/35 (71%)
		WD40 repeat	678..717	CDD:293791	33/38 (87%)
		WD40 repeat	724..748	CDD:293791	17/23 (74%)
strn3	XP_031746409.1	Striatin	44..169	CDD:400507	80/129 (62%)
		WD40	462..783	CDD:238121	209/320 (65%)
		WD40 repeat	472..518	CDD:293791	38/45 (84%)
		WD40 repeat	524..571	CDD:293791	29/46 (63%)
		WD40 repeat	576..613	CDD:293791	17/36 (47%)
		WD40 repeat	622..658	CDD:293791	13/35 (37%)
		WD40 repeat	671..707	CDD:293791	25/35 (71%)
		WD40 repeat	713..752	CDD:293791	33/38 (87%)
		WD40 repeat	759..783	CDD:293791	17/23 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3919
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	604	1.000	Inparanoid score	I921
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D334070at2759
OrthoFinder	1	1.000	-	-		FOG0001711
OrthoInspector	1	1.000	-	-		otm49303
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060