DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cka and STRN

DIOPT Version :9

Sequence 1:	NP_001245936.1	Gene:	Cka / 34096	FlyBaseID:	FBgn0044323	Length:	749	Species:	Drosophila melanogaster
Sequence 2:	XP_011531375.1	Gene:	STRN / 6801	HGNCID:	11424	Length:	809	Species:	Homo sapiens

Alignment Length:	878	Identity:	371/878 - (42%)
Similarity:	489/878 - (55%)	Gaps:	229/878 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GGGVGGANSSIGGVLSNSLGGGGSGGLS-ISGLNAGGQNANVGGMGNVGGDDGGNGMVGGGVNNQ 90
            |.||..:|        |..|.||:.||. ::...|.|..|...|
Human     6 GPGVFFSN--------NHPGAGGAKGLGPLAEAAAAGDGAAAAG--------------------- 41

  Fly    91 QATTPQYTIPGILHFIQHEWSRFELERSQWDVDRAELQARIAMLLGERKCLESLKSDLTRRIKML 155
             |...||::||||||:||||:|||:||:||:|:||||||:||.|.||||..|:||.||.||||||
Human    42 -AARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKML 105

  Fly   156 EYALRQERAKFYRLKYGTDPPQLNEFKPSNEDAGLAGEVATDSEVPYSSVSNTTWRQGRQMLRQY 220
            ||||:|||||:::|||||:..| .:.||.:.|:    :...::||.....|...|:||||:||||
Human   106 EYALKQERAKYHKLKYGTELNQ-GDMKPPSYDS----DEGNETEVQPQQNSQLMWKQGRQLLRQY 165

  Fly   221 LAEIGYTDNIIDVRSNRVRSILGLNNNA---EHDGSGGGLGGGLGGGTGGENLSPNINGNESNKR 282
            |.|:||||.|:||:|.|||::||.:::.   |.|                :|....:||.|:.
Human   166 LQEVGYTDTILDVKSKRVRALLGFSSDVTDREDD----------------KNQDSVVNGTEAE-- 212

  Fly   283 ASETEGRHTPAKKVQQSIDEIIVDTEAAVMANFEFL--GATEMSDDDEISDDLE----------- 334
                      .|:........:.|: |:|:.||:||  .|.:.||:|| .||::
Human   213 ----------VKETAMIAKSELTDS-ASVLDNFKFLESAAADFSDEDE-DDDVDGREKSVIDTST 265

  Fly   335 -------------------------MVATDNDDTDVKLA-------------------------- 348
                                     :|.::..|.:.:.|
Human   266 IVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVIT 330

  Fly   349 -------------------------------KRAKSG----------------KDMLTE------ 360
                                           |::|.|                :|||..
Human   331 KLKEQYKKERKGKKGVKRKTTEDLFQPLSYIKQSKQGCGRMKNQSLGPNRSKLQDMLANLRDVDE 395

  Fly   361 --DLEADVG-----------EQLLN---DMNLMT--------------EEVDGSLGLGELAQLTV 395
              .|:..||           |..:|   ::..:|              |.::..|||||||.|||
Human   396 LPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTV 460

  Fly   396 NNESDG-AYD-ANSKDGTGGSAGGAGYRKTWNAKYTLRSHFDGVRSLIFHPEEPVLITASEDHTL 458
            .||:|. .|| ||:||         ..|||||.|:||||||||:|:|.|||.|||||||||||||
Human   461 ANEADSLTYDIANNKD---------ALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTL 516

  Fly   459 KLWNLQKTVQAKKSASLDVEPLYTFRAHTGPVLCLGMSSSGETCYSGGLDGNIECWQLPSPNIDP 523
            |:||||||..||||.||||||:||||||.|||||:.|||:||.|||||.||.|:.|...:|||||
Human   517 KMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDP 581

  Fly   524 YDCYDPNVHSGTLEGHTDAVWGL--TTMQSNIVSCSADGTVKLWSPYNKEPLLRTYTASEAEGVP 586
            ||.|||:|..|.|.|||||||||  :.....::|||||||::||:.....|.|..:..::..|:|
Human   582 YDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIP 646

  Fly   587 SSVDFVRNEVDHIVVAYNSAHCIVYDTETGKQVVRLEAAQEMSGNTGKFINKVVSHPTLPITITA 651
            :|||.|.::..|:|.:::..:..:::.||.::::.||:..:.:.|:...||:|:|||||||:|||
Human   647 ASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITA 711

  Fly   652 HEDRHIRFWDNTSGTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNLDNKTCVQEITAH 716
            ||||||:|:||.:|.|:||||||||.|||||||.:||||:|||||||||||||::|||:||.|||
Human   712 HEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAH 776

  Fly   717 RKKFDESIFDVAFHATKPYIASAGADGLAKVFV 749
            ||||:|||.|||||.:|.||||||||.||||||
Human   777 RKKFEESIHDVAFHPSKCYIASAGADALAKVFV 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cka	NP_001245936.1	Striatin	98..228	CDD:285445	76/129 (59%)
		WD40	427..>748	CDD:225201	203/322 (63%)
		WD40	429..748	CDD:238121	202/320 (63%)
		WD40 repeat	439..485	CDD:293791	37/45 (82%)
		WD40 repeat	491..538	CDD:293791	29/46 (63%)
		WD40 repeat	543..578	CDD:293791	15/36 (42%)
		WD40 repeat	587..629	CDD:293791	10/41 (24%)
		WD40 repeat	636..672	CDD:293791	26/35 (74%)
		WD40 repeat	678..717	CDD:293791	31/38 (82%)
		WD40 repeat	724..748	CDD:293791	18/23 (78%)
STRN	XP_011531375.1	Striatin	48..173	CDD:285445	76/129 (59%)
		WD40	458..>802	CDD:225201	215/352 (61%)
		WD40	484..808	CDD:238121	203/323 (63%)
		WD40 repeat	497..543	CDD:293791	37/45 (82%)
		WD40 repeat	549..596	CDD:293791	29/46 (63%)
		WD40 repeat	601..637	CDD:293791	15/35 (43%)
		WD40 repeat	645..683	CDD:293791	9/37 (24%)
		WD40 repeat	696..732	CDD:293791	26/35 (74%)
		WD40 repeat	738..774	CDD:293791	29/35 (83%)
		WD40 repeat	784..808	CDD:293791	18/23 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145618
Domainoid	1	1.000	163	1.000	Domainoid score	I3962
eggNOG	1	0.900	-	-		E1_KOG0642
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	724	1.000	Inparanoid score	I625
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55995
OrthoDB	1	1.010	-	-		D194096at33208
OrthoFinder	1	1.000	-	-		FOG0001711
OrthoInspector	1	1.000	-	-		otm42075
orthoMCL	1	0.900	-	-		OOG6_101735
Panther	1	1.100	-	-	O	PTHR15653
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1845
SonicParanoid	1	1.000	-	-		X1258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800