DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cka and strn4

DIOPT Version :9

Sequence 1:	NP_001245936.1	Gene:	Cka / 34096	FlyBaseID:	FBgn0044323	Length:	749	Species:	Drosophila melanogaster
Sequence 2:	XP_021321999.1	Gene:	strn4 / 562780	ZFINID:	ZDB-GENE-070501-3	Length:	768	Species:	Danio rerio

Alignment Length:	815	Identity:	335/815 - (41%)
Similarity:	455/815 - (55%)	Gaps:	145/815 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GGGVGGANSSIGGVLSNSLGGGGSGGLSISGLNAGGQNANVGGMGNVGGDDGGNGMVGGGVN-NQ 90
            ||..||.:.|          ..|||    :|.|..|..|.:|...:.........|.|...: :|
Zfish     7 GGMAGGTSQS----------PAGSG----TGRNPNGPKAVLGPAPSAVAAAAAGPMAGSSQSRDQ 57

  Fly    91 QATTPQYTIPGILHFIQHEWSRFELERSQWDVDRAELQARIAMLLGERKCLESLKSDLTRRIKML 155
            |......::||||||||:|||||:.|:.:|:.:|.||:|::|.|.||||..|::|.||.||||||
Zfish    58 QDGDAGLSLPGILHFIQYEWSRFQAEKYRWEAERDELRAQVAFLQGERKGQENMKQDLVRRIKML 122

  Fly   156 EYALRQERAKFYRLKYGTDPPQLNEFKPSNEDAGLA-GEVATDSEVPYSSVSNTTWRQGRQMLRQ 219
            ||||:|||||..:||.|||... .|.||..|...:. |...:|||    ..:...|::|||:||:
Zfish   123 EYALKQERAKHQKLKSGTDQSP-GEKKPETEAEPIPNGPANSDSE----PTNQMPWKEGRQLLRK 182

  Fly   220 YLAEIGYTDNIIDVRSNRVRSILGLNNNAEHDGSGG-----------GLGGGLGGGTGGENLSPN 273
            ||.|:||:|.|:|:||.||||:|| .|:.|.:|...           |:||      |||:|...
Zfish   183 YLEEVGYSDTILDMRSKRVRSLLG-RNSPEANGPPSSEPTTEPEPHVGVGG------GGESLLVR 240

  Fly   274 INGNESNKRASETEGRHTPAKKVQQSIDEIIVDTEAAVMANFEFLGATEMSDDDEI--SDDLEMV 336
            ....:..:||    |:.:..:::..|           |:....||...|..|:|:.  .:|.:.:
Zfish   241 QIEEQIKRRA----GKESSKERMGSS-----------VLDKIPFLRGCEDDDEDDSDEEEDFQGM 290

  Fly   337 ATDNDDTDVKLAKRAKSGKDMLTEDL------EADVGEQLLNDMNLMT--EEVDGS--------- 384
            .||..|.......|||.|.:.:|.||      :.|..|..|.:.:.:.  ||.:|:
Zfish   291 TTDCIDGRKNKKSRAKMGGEPMTTDLDPEDEDDEDDSEDALGEFDFLASGEEGEGAGEARISGDG 355

  Fly   385 ---------------------------------------------------------LGLGELAQ 392
                                                                     :.|||||.
Zfish   356 RELGSENRRNKLQGIMSDFPPKPTPPPSIPGQARSGEGGALGFSSDVFILDAVGGGDMNLGELAD 420

  Fly   393 LTVNNESDGAYD-ANSKDGTGGSAGGAGYRKTWNAKYTLRSHFDGVRSLIFHPEEPVLITASEDH 456
            |||.|::|...| .:|::         .::||||.::|||||||.:|:|.|||.:.||::||||.
Zfish   421 LTVANDNDLTIDLQDSRE---------EFKKTWNPRFTLRSHFDAIRALSFHPSQAVLLSASEDG 476

  Fly   457 TLKLWNLQKTVQAKKSASLDVEPLYTFRAHTGPVLCLGMSSSGETCYSGGLDGNIECWQLPSPNI 521
            |||||||.|.:.:||:|:|||||:||||||:|.||.|.|...||:|:||||||.|..|::|..|:
Zfish   477 TLKLWNLNKAMHSKKNAALDVEPIYTFRAHSGAVLSLAMGEEGESCFSGGLDGTIRGWKIPDLNV 541

  Fly   522 DPYDCYDPNVHSGTLEGHTDAVWGLTTMQS--NIVSCSADGTVKLWSPYNKEPLLRTYTASEAEG 584
            ||||.|||.|.|..|.||.||||||....|  .:.||||||||::|.|:|..|.:..:...:..|
Zfish   542 DPYDNYDPGVESSVLSGHEDAVWGLAFSSSLQRLASCSADGTVRIWDPHNSSPCVSVFNKEKEHG 606

  Fly   585 VPSSVDFVRNEVDHIVVAYNSAHCIVYDTETGKQVVRLEAAQEMSGNTGKFINKVVSHPTLPITI 649
            .|:||.||..:...:||:::....::||..|.:.::.|| .|...|:  :.||:|||||:.||:|
Zfish   607 TPTSVAFVNADPSQVVVSFDGGETLLYDLNTEQSIMVLE-TQTKDGS--ELINRVVSHPSQPISI 668

  Fly   650 TAHEDRHIRFWDNTSGTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNLDNKTCVQEIT 714
            ||||:|.|||.||.:|.::|||||||:.||.||.|..|.||:|||||||:|||.|||:|||||||
Zfish   669 TAHENRTIRFLDNNTGKVIHSMVAHLDAVTCLATDPKGTYLISGSHDCSVRLWMLDNRTCVQEIT 733

  Fly   715 AHRKKFDESIFDVAFHATKPYIASAGADGLAKVFV 749
            |||||.||:|.|||||.::|:|||||||.|||:||
Zfish   734 AHRKKHDEAIHDVAFHPSQPFIASAGADALAKIFV 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cka	NP_001245936.1	Striatin	98..228	CDD:285445	68/130 (52%)
		WD40	427..>748	CDD:225201	184/322 (57%)
		WD40	429..748	CDD:238121	184/320 (58%)
		WD40 repeat	439..485	CDD:293791	29/45 (64%)
		WD40 repeat	491..538	CDD:293791	26/46 (57%)
		WD40 repeat	543..578	CDD:293791	17/36 (47%)
		WD40 repeat	587..629	CDD:293791	12/41 (29%)
		WD40 repeat	636..672	CDD:293791	23/35 (66%)
		WD40 repeat	678..717	CDD:293791	29/38 (76%)
		WD40 repeat	724..748	CDD:293791	17/23 (74%)
strn4	XP_021321999.1	Striatin	65..191	CDD:311929	68/130 (52%)
		WD40	446..767	CDD:238121	184/323 (57%)
		WD40 repeat	459..505	CDD:293791	29/45 (64%)
		WD40 repeat	511..558	CDD:293791	26/46 (57%)
		WD40 repeat	563..600	CDD:293791	17/36 (47%)
		WD40 repeat	609..645	CDD:293791	9/35 (26%)
		WD40 repeat	655..691	CDD:293791	23/35 (66%)
		WD40 repeat	697..737	CDD:293791	30/39 (77%)
		WD40 repeat	743..767	CDD:293791	17/23 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579008
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55995
OrthoDB	1	1.010	-	-		D194096at33208
OrthoFinder	1	1.000	-	-		FOG0001711
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101735
Panther	1	1.100	-	-	LDO	PTHR15653
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860