DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cka and Strn

DIOPT Version :9

Sequence 1:	NP_001245936.1	Gene:	Cka / 34096	FlyBaseID:	FBgn0044323	Length:	749	Species:	Drosophila melanogaster
Sequence 2:	XP_006239684.1	Gene:	Strn / 29149	RGDID:	3782	Length:	809	Species:	Rattus norvegicus

Alignment Length:	877	Identity:	372/877 - (42%)
Similarity:	494/877 - (56%)	Gaps:	227/877 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GGGVGGANSSIGGVLSNSLGGGGSGGLS-ISGLNAGGQNANVGGMGNVGGDDGGNGMVGGGVNNQ 90
            |.||..:|        |..|.||:.||. ::...|.|..|...|
  Rat     6 GPGVFFSN--------NHPGAGGAKGLGPLAEAAAAGDGAAAAG--------------------- 41

  Fly    91 QATTPQYTIPGILHFIQHEWSRFELERSQWDVDRAELQARIAMLLGERKCLESLKSDLTRRIKML 155
             |...||::||||||:||||:|||:||:||:|:||||||:||.|.||||..|:||.||.||||||
  Rat    42 -AARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKML 105

  Fly   156 EYALRQERAKFYRLKYGTDPPQLNEFKPSNEDAGLAGEVATDSEVPYSSVSNTTWRQGRQMLRQY 220
            ||||:|||||:::|||||:..| .:.||.:.|:    :...::||.....|...|:||||:||||
  Rat   106 EYALKQERAKYHKLKYGTELNQ-GDMKPPSYDS----DEGNETEVQPQQNSQFMWKQGRQLLRQY 165

  Fly   221 LAEIGYTDNIIDVRSNRVRSILGLNNNA---EHDGSGGGLGGGLGGGTGGENLSPNINGNESNKR 282
            |.|:||||.|:||:|.|||::||.:::.   |.|                :|....|||.|:..:
  Rat   166 LQEVGYTDTILDVKSKRVRALLGFSSDVTDREDD----------------KNQDSVINGTEAEVK 214

  Fly   283 ASETEGRHTPAKKVQQSIDEIIVDTEAAVMANFEFL--GATEMSDDDE----------------- 328
            .:...|:..            :.|: |:|:.||:||  .|.:.||:||
  Rat   215 ETAMIGKSE------------LTDS-ASVLDNFKFLENAAADFSDEDEDEDIDGREKSVIDTSTI 266

  Fly   329 --------ISDDLE----------MVATDNDDTDVKLA--------------------------- 348
                    .|:|.:          :||::..|.:.:.|
  Rat   267 VRKKPLPDTSEDRDTKEALKEFDFLVASEEGDNESRSAGDGTDWEKEDQCLTPEAWNVDQGVITR 331

  Fly   349 ------------------------------KRAKSG----------------KDMLTE------- 360
                                          |::|.|                :|||..
  Rat   332 LKEQYKKERKGKKGVKRKTTEDLFQPLSYIKQSKQGCGRMKKQSPGPNRSKLQDMLANLRDVDEL 396

  Fly   361 -DLEADVG-----------EQLL---NDMNLMT--------------EEVDGSLGLGELAQLTVN 396
             .|:..||           ||.:   :::..:|              |.::..|||||||.|||.
  Rat   397 PSLQPSVGSPSRPSSSRLPEQDISRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVA 461

  Fly   397 NESDG-AYD-ANSKDGTGGSAGGAGYRKTWNAKYTLRSHFDGVRSLIFHPEEPVLITASEDHTLK 459
            ||:|. ||| ||:||         ..|||||.|:||||||||:|:|.|||.||||||||||||||
  Rat   462 NEADSLAYDIANNKD---------ALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLK 517

  Fly   460 LWNLQKTVQAKKSASLDVEPLYTFRAHTGPVLCLGMSSSGETCYSGGLDGNIECWQLPSPNIDPY 524
            :||||||..||||.||||||:||||||.|||||:.|||:||.|||||.||.|:.|...:||:|||
  Rat   518 MWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQSWSTTNPNVDPY 582

  Fly   525 DCYDPNVHSGTLEGHTDAVWGL--TTMQSNIVSCSADGTVKLWSPYNKEPLLRTYTASEAEGVPS 587
            |.|||:|..|.|.|||||||||  :.....::|||||||::||:.....|.|..:..::..|:|:
  Rat   583 DSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWTTTEVAPALTVFNDNQELGIPA 647

  Fly   588 SVDFVRNEVDHIVVAYNSAHCIVYDTETGKQVVRLEAAQEMSGNTGKFINKVVSHPTLPITITAH 652
            |||.|.::..|:|.:::..:..:::.||.::::.||:..:.:.::...||:|:|||||||:||||
  Rat   648 SVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDSTASSSCQINRVISHPTLPISITAH 712

  Fly   653 EDRHIRFWDNTSGTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNLDNKTCVQEITAHR 717
            |||||:|:||.:|.|:||||||||.|||||||.:||||:|||||||||||||::|||:||.||||
  Rat   713 EDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHR 777

  Fly   718 KKFDESIFDVAFHATKPYIASAGADGLAKVFV 749
            |||:|||.|||||.:|.||||||||.||||||
  Rat   778 KKFEESIHDVAFHPSKCYIASAGADALAKVFV 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cka	NP_001245936.1	Striatin	98..228	CDD:285445	76/129 (59%)
		WD40	427..>748	CDD:225201	201/322 (62%)
		WD40	429..748	CDD:238121	200/320 (63%)
		WD40 repeat	439..485	CDD:293791	37/45 (82%)
		WD40 repeat	491..538	CDD:293791	28/46 (61%)
		WD40 repeat	543..578	CDD:293791	15/36 (42%)
		WD40 repeat	587..629	CDD:293791	10/41 (24%)
		WD40 repeat	636..672	CDD:293791	26/35 (74%)
		WD40 repeat	678..717	CDD:293791	31/38 (82%)
		WD40 repeat	724..748	CDD:293791	18/23 (78%)
Strn	XP_006239684.1	Striatin	48..173	CDD:285445	76/129 (59%)
		WD40	<478..807	CDD:225201	205/328 (63%)
		WD40	484..808	CDD:238121	201/323 (62%)
		WD40 repeat	497..543	CDD:293791	37/45 (82%)
		WD40 repeat	549..596	CDD:293791	28/46 (61%)
		WD40 repeat	601..638	CDD:293791	15/36 (42%)
		WD40 repeat	647..683	CDD:293791	8/35 (23%)
		WD40 repeat	696..732	CDD:293791	26/35 (74%)
		WD40 repeat	738..774	CDD:293791	29/35 (83%)
		WD40 repeat	784..808	CDD:293791	18/23 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339309
Domainoid	1	1.000	167	1.000	Domainoid score	I3757
eggNOG	1	0.900	-	-		E1_KOG0642
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	710	1.000	Inparanoid score	I618
OMA	1	1.010	-	-		QHG55995
OrthoDB	1	1.010	-	-		D194096at33208
OrthoFinder	1	1.000	-	-		FOG0001711
OrthoInspector	1	1.000	-	-		otm46219
orthoMCL	1	0.900	-	-		OOG6_101735
Panther	1	1.100	-	-	O	PTHR15653
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1258
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770