DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7367 and LPL

DIOPT Version :10

Sequence 1:NP_609175.2 Gene:CG7367 / 34094 FlyBaseID:FBgn0031976 Length:389 Species:Drosophila melanogaster
Sequence 2:NP_000228.1 Gene:LPL / 4023 HGNCID:6677 Length:475 Species:Homo sapiens


Alignment Length:269 Identity:93/269 - (34%)
Similarity:132/269 - (49%) Gaps:42/269 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 EFPQRHKRDTWQE-------MAEK-----FNPELDTKILVHGWKSSTMSNS--IQSIRGAYIERG 168
            :|..|...||.::       :||.     ||....|.:::|||..:.|..|  .:.:...|....
Human    40 KFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREP 104

  Fly   169 QVNVFAINWKDQADNIYYLTPARYTVQVGRAVAKLIDLLVEEKDADPNRIHLIGHSLGAHIMGYA 233
            ..||..::|..:|.. :|...|.||..||:.||:.|:.:.||.:...:.:||:|:|||||..|.|
Human   105 DSNVIVVDWLSRAQE-HYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIA 168

  Fly   234 GSYTKYRVNRITGLDPARPAFEDCIGPENHLDDTDANFVDVIH-----SCAGYLGFRKPIGMVDF 293
            ||.|..:||||||||||.|.||....| :.|...||:||||:|     |....:|.:||:|.||.
Human   169 GSLTNKKVNRITGLDPAGPNFEYAEAP-SRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDI 232

  Fly   294 YPNGGGPPQPGCK--------------ELSQIFTGCSHGRSYEYYAESI---NSPKGFYGVPCSG 341
            ||| ||..||||.              ::.|: ..|||.||...:.:|:   .:|...|  .||.
Human   233 YPN-GGTFQPGCNIGEAIRVIAERGLGDVDQL-VKCSHERSIHLFIDSLLNEENPSKAY--RCSS 293

  Fly   342 LDELKGKNC 350
            .:..:...|
Human   294 KEAFEKGLC 302

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7367NP_609175.2 Pancreat_lipase_like 115..374 CDD:238363 93/269 (35%)
LPLNP_000228.1 Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:30559189 32..53 4/12 (33%)
lipo_lipase 33..473 CDD:132274 93/269 (35%)
Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706 243..266 2/23 (9%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000269|PubMed:27929370 417..421
Important for heparin binding. /evidence=ECO:0000269|PubMed:11342582 430..434
Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:26725083, ECO:0000269|PubMed:30559189 443..467
Blue background indicates that the domain is not in the aligned region.

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