DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and TGM5

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_963925.2	Gene:	TGM5 / 9333	HGNCID:	11781	Length:	720	Species:	Homo sapiens

Alignment Length:	748	Identity:	242/748 - (32%)
Similarity:	362/748 - (48%)	Gaps:	87/748 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHF-NRDYSPSKDAISF------ 111
            |.|...||....|:..|||...    ..:.|:||||:.|.|.::| ||.:.|..|.|.|
Human     5 LEVALTDLQSSRNNVRHHTEEI----TVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETGP 65

  Fly   112 ----------IFTVADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPS 166
                      :|::|....|||                      |.|.:|::...:..|.:..|.
Human    66 LPDLALGTRAVFSLARHHSPSP----------------------WIAWLETNGATSTEVSLCAPP 108

  Fly   167 TCPVTEWKLDIDTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGS 231
            |..|..:.|.|..........:|.|. ...:|||||||:|.|||:...||:||||:|...|::||
Human   109 TAAVGRYLLKIHIDSFQGSVTAYQLG-EFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGS 172

  Fly   232 YNRLRPSVWKIGQFERHVLECSLKVLG------TVGRIPPAYRGDPVRVARALSALVNSVDDDGV 290
            .|.:||..|..||||..:::..||:|.      |......|.||.||.|:|.:.|::||.||:||
Human   173 KNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGV 237

  Fly   291 LLGNWSEDFSGGVAPTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCY 354
            |.|||||:::.|..|.:|||||.||:|:..|. :.|::.|||.|:.|:.|:.|.||||:|:||.:
Human   238 LNGNWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNF 302

  Fly   355 SSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATP 419
            .|.|||..:|.:|.:.|...:.|..:..|:|||:|||||.||.|.||    ...:.||||:||||
Human   303 DSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDL----PPAYGGWQVLDATP 363

  Fly   420 QEASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHL 484
            ||.|:.:|..|||||.|:|.|::...:|..|||:.||||.:.|...|..:  :.|.:||.::|:.
Human   364 QEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKE--QKLHQDTSSVGNF 426

  Fly   485 ISTKAVLKWEREDITDTYKHAERSEEERSTMLKALK----QSRHAFSR----------------- 528
            ||||::...||:|||:.||:.|.|.:||...||||:    :|.|...|
Human   427 ISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSP 491

  Fly   529 ------YYLNDNFNDIEFDMELKDDIKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGA 587
                  .....:...:....:|.|...:||....||...|.|.....:.. .:|..::|:.|...
Human   492 RSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKV-NLSAQSLLHDGSPL 555

  Fly   588 VEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKP 652
            .........:.|.||.:.....::.:.:|...||:....:|||..:.|.:...........:..|
Human   556 SPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYP 620

  Fly   653 DIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPGI-EQPLKFKIAEIPVGGTAAATF 716
            .|...:..||:|.| .|.:.:...|||...:...|.||||.|: ::..|..:..:.....|:...
Human   621 SITINVLGAAVVNQ-PLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIIL 684

  Fly   717 KYTPPYAGRGTMLAKFTSKELDDVDGYRHYEIE 749
            :..|..:|:..:.|...|.:..|:.|||:..::
Human   685 ETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVD 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	35/139 (25%)
		TGc	324..419	CDD:214673	43/94 (46%)
		Transglut_C	538..644	CDD:279295	21/105 (20%)
		Transglut_C	652..750	CDD:279295	26/99 (26%)
TGM5	NP_963925.2	Transglut_N	4..121	CDD:307149	36/141 (26%)
		TGc	270..363	CDD:214673	43/96 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..499		2/28 (7%)
		Transglut_C	507..606	CDD:307191	21/99 (21%)
		Transglut_C	620..717	CDD:307191	26/97 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5146
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41720
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920