DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm1l3

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_001331914.1	Gene:	tgm1l3 / 793448	ZFINID:	ZDB-GENE-120718-1	Length:	848	Species:	Danio rerio

Alignment Length:	719	Identity:	256/719 - (35%)
Similarity:	376/719 - (52%)	Gaps:	46/719 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DKTDGASSA------VLGVLKVDL--CLE-DNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFN 99
            |..|..::|      ||.|..|||  |.: .|.:||||:.|..    :.|:||||:.|::.:..:
Zfish   149 DCADDCNAARCCEDLVLQVRCVDLMKCWKSQNRQEHHTNGFRG----DHLIVRRGQCFQMWVELS 209

  Fly   100 RDYSPSKDAISFIFTVADDTKPSPGHGTLNALVPHDGIDYLGDTLE---WGAGI-ESHEGQTLTV 160
            |.::|..|.:.....:.:  .||..:||| .:||      |.:..:   |.|.| |..:.:....
Zfish   210 RPFNPKCDQLHLELKLGN--VPSIPNGTL-VIVP------LVEEFKKNRWEAKIVEKCQNRIKLS 265

  Fly   161 LIKPPSTCPVTEWKLDIDTKLLGDGSRSYPLPLP---IYVLFNPWCPDDQVYLEDRDQRKEYVMH 222
            :...|:.| :..:.|.|.|  .|...|:.....|   ||:||||||.||.|||::..||.|||::
Zfish   266 VYSLPTAC-IGRYSLTIVT--CGPKGRATSSCNPSNDIYMLFNPWCKDDAVYLDEDAQRTEYVLN 327

  Fly   223 DTTLIWRGSYNRLRPSVWKIGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDD 287
            ||..|:.|:.:::....|..|||:..||...|.||...|.....: ||||.|||.:||:||:.||
Zfish   328 DTGKIFYGTKHQIASRTWHFGQFDEGVLAACLFVLEKCGGACSGW-GDPVNVARVVSAMVNANDD 391

  Fly   288 DGVLLGNWSEDFSGGVAPTKWTGSVEILQQFYKT-QKSVKFAQCWNFSGVLTTIARSLGIPSRII 351
            .|||:||||..::.|.|||.|.||..||:|::|. ...||:.|...|:||..|:.|..|||:|.:
Zfish   392 SGVLMGNWSNCYADGTAPTAWCGSSAILKQYHKCGGVPVKYGQSLAFAGVTNTLLRCFGIPARPV 456

  Fly   352 TCYSSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVD 416
            |.:.|||||..|:|||:::|.|...:|:...||||.:|||||.||.|.||..|    |.|||.:|
Zfish   457 TNFCSAHDTDVSMTVDIYLDENYDLIDSLNRDSIWTFHVWNEAWMARSDLPAG----FGGWQAID 517

  Fly   417 ATPQEASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAI 481
            |||||.|..::|.||.||||:::|.:...:|..|:|||||:|.::|:... .....::..|..|:
Zfish   518 ATPQETSQGVFRCGPTSVAAIRSGQVFLKYDAPFIFAEVNSDVVFWQRKA-CGTFAVVHVDKNAV 581

  Fly   482 GHLISTKAVLKWEREDITDTYKHAERSEEERSTMLKALKQSRHAFSR-YYLNDNFNDIEFDMELK 545
            ||.||||||...:|.|||:.|||.|.|||||..:..||   ||...: .|......|:..|:.:|
Zfish   582 GHCISTKAVGSDKRVDITNHYKHPEGSEEERRAVETAL---RHGSKKCAYPLPCAEDVICDITMK 643

  Fly   546 -DDIKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRM 609
             |.:.:|:...:.:.:.||..| |...|......|..|||:....||......||:...:..:..
Zfish   644 GDGVCVGKDAVLCIALKNKCSS-TRSVTLHSQLSAAYYTGIHKSLVKKDQTCFELKATETKVLEW 707

  Fly   610 EVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILR 674
            .:.:|:|.:.|...:...::.|.:|..|......:.:||:..|.:....|...:|. ||:.|.:.
Zfish   708 SLKYEDYKNHLVDHSTMMVTVAGRVTQTQQIVAKRFNFRLPTPGLAISPGCDCVVG-KEVPVKIT 771

  Fly   675 LENPLPIPLHKGVFTVEGPGIEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDD 739
            .:||||..|...:|.:||.|::........:|....|...|.|:.|...|...:||.....:|..
Zfish   772 FQNPLPCVLKNAIFRIEGLGLKHCRSINYGDIAGLATVNLTEKFIPKCHGPHKLLASLDCPQLTQ 836

  Fly   740 VDGY 743
            |.|:
Zfish   837 VHGF 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	36/129 (28%)
		TGc	324..419	CDD:214673	46/94 (49%)
		Transglut_C	538..644	CDD:279295	23/106 (22%)
		Transglut_C	652..750	CDD:279295	26/92 (28%)
tgm1l3	XP_001331914.1	Cornifin	42..>128	CDD:280537
		Transglut_N	166..283	CDD:279240	36/130 (28%)
		YebA	<428..565	CDD:224224	68/140 (49%)
		TGc	429..520	CDD:214673	46/94 (49%)
		Transglut_C	639..730	CDD:279295	20/91 (22%)
		Transglut_C	761..846	CDD:279295	24/81 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5000
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H306
Inparanoid	1	1.050	449	1.000	Inparanoid score	I1594
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	1	1.000	-	-		FOG0001456
OrthoInspector	1	1.000	-	-		otm24798
orthoMCL	1	0.900	-	-		OOG6_102867
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1344
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970