Protein Alignment Tg and tgm1l2

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_009295369.1
• Gene: tgm1l2 / 793096
• ZFINID: ZDB-GENE-110408-37
• Length: 853
• Species: Danio rerio
• Alignment Length: 762
• Identity: 248/762 - (32%)
• Similarity: 377/762 - (49%)
• Gaps: 60/762 - (7%)

  Fly     7 CCQKCGDWKWCTSKDNEESTLRIRNANANYFTGIPQGDKTDGASSAVLGVLKVDL--CLEDNHEE 69
            |...|..:.:   :|.|...:..|....:..|     .:......|:|.|.||||  |....:..
Zfish   131 CATPCSTYSY---RDYESRQVVTRECIDDCTT-----KRVCATDEALLRVSKVDLLSCRTGPNRM 187

  Fly    70 HHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVADDTKPSPGHGTLNALVPH 134
            .|.:||:   .:|.|:||||:.|.:.|...|.::|:.|.:.....:..  .||...||. .:||
Zfish   188 EHRTHFF---HEEKLIVRRGQCFNMWIDLCRPFNPTCDKLHLELRLGH--IPSIRDGTY-VIVP- 245

  Fly   135 DGIDYLGDTLE---WGAGIESHEGQTLTVLIKP-PSTCPVTEWKLDIDTKLLGDGSRSYPLP-LP 194
                 :.|..:   |||.|.......|.:.:.. |::| |..::|.:.|..   .:..:.|| :|
Zfish   246 -----IVDEFKKDCWGARIVERCQNRLKLCVNSLPTSC-VGRYQLSVVTHC---SAGRFCLPYVP 301

  Fly   195 ---IYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQFERHVLECSLKV 256
               ||:||||||.:|.|||.:..:|.|||::|...|:.|:.:::....|..||||..:|.....|
Zfish   302 ENDIYMLFNPWCKEDCVYLHEETERAEYVLNDIGKIYYGTKHQIGCKSWNFGQFEEGILPACFYV 366

  Fly   257 LGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPTKWTGSVEILQQFYKT 321
            | .....|.:..|:|:.::|.:|.:|.:..|.|||:||||..::.|:|||.|.||..||:|:||.
Zfish   367 L-EKSCAPCSGWGNPINISRVVSDMVIAKKDCGVLMGNWSNCYTDGIAPTSWCGSSAILRQYYKC 430

  Fly   322 QKS-VKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFIDANNKKLDAETTDSI 385
            ..: |::.|...|:||..|:.|.||||:|.::.:.|||||...||.||::|...:.:|....:.|
Zfish   431 GGAPVRYGQSLAFAGVTNTMLRCLGIPTRPVSNFCSAHDTDMCLTSDVYLDEKFQLIDHMNANPI 495

  Fly   386 WNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAAVKNGDILRPFDGGF 450
            ||||||||.||.||||..|    |.|||.:|:|||......:|.||.||||:::|......|..|
Zfish   496 WNYHVWNEAWMTRPDLPTG----FGGWQAIDSTPQLTHQGFFRCGPTSVAAIRSGQTFLKHDVPF 556

  Fly   451 VFAEVNADKLYW--RYNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDTYKHAERSEEERS 513
            :|||||.||:||  :.:|....:. :.||  .:||.||||||...:|.|||:.|||...||:..:
Zfish   557 LFAEVNNDKVYWQRKCDGTFGVVH-VEKD--VVGHCISTKAVGSDQRLDITNLYKHPCGSEDRCT 618

  Fly   514 TMLKALKQSRHAFSRYYLNDNF-----NDIEFDMELKDDIK-IGQSFSVVLKVSNKSESRTHMAT 572
            .:..||   ||...|.    |:     .|:..::.||.|.. :|:...|.:.:.||. ::....|
Zfish   619 ALETAL---RHGCRRI----NYPLPCAEDVVCEVNLKGDGPCVGRDAVVCINLRNKC-NQPRSVT 675

  Fly   573 GQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKDT 637
            ......|:.||||....:|.....:||:|.....:...:.::||.:.|...|...::....|..|
Zfish   676 LYSHAAAMYYTGVRRTYLKRDQTCIELKPSECKPLEWTLSYDEYKEHLVDHAPLMLNLFGHVAQT 740

  Fly   638 DYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPGIEQPLKFK 702
            ......|.:||:|.||:.......|:|.| |:.|.:..:|||...|....|...|.|::.|....
Zfish   741 KQILATQYNFRLRTPDLVLAPACDAVVGQ-EVAVKVTFQNPLSCVLRNAAFRFVGLGLQHPRIIN 804

  Fly   703 IAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVDGYRHYEIE 749
            ..:|....|.:.|.|:.|...|...:||.|...:|..|.|:.:..::
Zfish   805 YGDIAGHATVSLTEKFIPMCHGPQKLLASFDCPQLTQVHGFTNMVVK 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	35/127 (28%)
		TGc	324..419	CDD:214673	44/95 (46%)
		Transglut_C	538..644	CDD:460002	23/106 (22%)
		Transglut_C	652..750	CDD:460002	27/98 (28%)
tgm1l2	XP_009295369.1	Transglut_N	174..288	CDD:459971	35/126 (28%)
		TGc	434..525	CDD:214673	44/94 (47%)
		Transglut_C	649..747	CDD:460002	21/98 (21%)
		Transglut_C	764..852	CDD:460002	25/89 (28%)