Protein Alignment Tg and Tgm5

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_083075.1
• Gene: Tgm5 / 74176
• MGIID: 1921426
• Length: 724
• Species: Mus musculus
• Alignment Length: 734
• Identity: 249/734 - (33%)
• Similarity: 375/734 - (51%)
• Gaps: 60/734 - (8%)

  Fly    54 LGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHF-NRDYSPSKDAISFIFTVAD 117
            |.|...||....|:..|||...    :.:.||||||:.|.:.::| ||.:.|..|:|.|:    .
Mouse    10 LEVALTDLQSSQNNVRHHTEEI----SVDRLVVRRGQAFSITLYFKNRGFQPGMDSIMFV----A 66

  Fly   118 DTKPSP--GHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTK 180
            :|.|.|  ..|| .|:....|   .|....|.|.:|::...:|.|.:..|....|..:.|.|...
Mouse    67 ETGPLPDLAKGT-RAVFSFTG---SGGPSPWIASLEANRANSLEVSLCAPPIAAVGRYLLKIRID 127

  Fly   181 LLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQF 245
            .......:|.|. ...:|||||||.|.||||...||:|||::|...|::||.:.:||..|..|||
Mouse   128 SYQGFVTAYQLG-EFILLFNPWCPADSVYLESEPQRQEYVVNDYGFIYQGSKSWIRPCPWNYGQF 191

  Fly   246 ERHVLECSLKVL--GTVGRIPP----AYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVA 304
            |.::::..|::|  ....::.|    |.||.||..:|.:.|::||.||:|||.|||||::..|:.
Mouse   192 EENIIDICLELLEKSLNFQVDPSTDCALRGSPVYTSRVVCAMINSNDDNGVLNGNWSENYVDGIN 256

  Fly   305 PTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDV 368
            |.:|||||.||:|::.|. :.|::.|||.|:.|:.|:.|.||||:|:||.:.|.|||..:|.:|.
Mouse   257 PAEWTGSVAILKQWHATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDE 321

  Fly   369 FIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPAS 433
            :.|...:.|:....|::||:|||||.||.|.||..|    :.||||:||||||.|:.:|..||||
Mouse   322 YYDNTGRILENMKKDTVWNFHVWNECWMARKDLPPG----YGGWQVLDATPQETSNGLYCCGPAS 382

  Fly   434 VAAVKNGDILRPFDGGFVFAEVNADKLYWR-YNGPSQPLKLLRKDTLAIGHLISTKAVLKWERED 497
            |.|:|.|:|...:|..|.|:.||||.:.|. |.|..|.   |.:||..:|:.||||::...||:|
Mouse   383 VKAIKEGEIDLNYDTRFAFSMVNADCMSWLVYGGKEQK---LHQDTATVGNFISTKSIQSDERDD 444

  Fly   498 ITDTYKHAERSEEERSTMLKALK--QSRHAFSRYYLNDN-FN----------------------- 536
            ||::||:.|.|.:||...||||:  |:..:...:..|.| |:
Mouse   445 ITESYKYEEGSLQEREVFLKALQKLQATRSQGPHQANSNPFSSVPPRHNSARSPDSPSLQPSDVL 509

  Fly   537 DIEFDMELKDDIKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEP 601
            .:....||.|..|:||..:.||...|.|.....:.. .:|..::|:.|...|........:.|.|
Mouse   510 QVSLKFELLDSPKMGQDINFVLLAVNMSPQFKDLKL-NLSAQSLLHDGSPLVPFWQDTAFITLFP 573

  Fly   602 KSSDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQ 666
            :.......::::.:|...||:....:|||..:.|::...........:..|.|...:..||.|.|
Mouse   574 EEEKSYPCKILYSQYSQYLSTDKLIRISALGEEKNSPEKILVNKIITLTFPGIMINVLGAAFVNQ 638

  Fly   667 KELDVILRLENPLPIPLHKGVFTVEGPGI-EQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLA 730
             .|.|.:...|||..|:...|.|:||.|: .:..:..|..:.....|:.|.|..|..:|:..:.|
Mouse   639 -PLTVQVVFSNPLSEPVEDCVLTLEGSGLFRKQQRVLIGVLKPHHKASITLKTVPFKSGQRQIQA 702

  Fly   731 KFTSKELDDVDGYRHYEIE 749
            ...|....|:.||::..::
Mouse   703 NLRSNRFKDIKGYKNVYVD 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	37/124 (30%)
		TGc	324..419	CDD:214673	43/94 (46%)
		Transglut_C	538..644	CDD:460002	23/105 (22%)
		Transglut_C	652..750	CDD:460002	28/99 (28%)
Tgm5	NP_083075.1	Transglut_N	16..126	CDD:459971	37/121 (31%)
		TGc	275..368	CDD:214673	43/96 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	473..505		3/31 (10%)
		Transglut_C	511..606	CDD:460002	22/95 (23%)
		Transglut_C	624..721	CDD:460002	28/97 (29%)