Protein Alignment Tg and TGM3

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_003236.3
• Gene: TGM3 / 7053
• HGNCID: 11779
• Length: 693
• Species: Homo sapiens
• Alignment Length: 699
• Identity: 238/699 - (34%)
• Similarity: 362/699 - (51%)
• Gaps: 41/699 - (5%)

  Fly    52 AVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVA 116
            |.|||..::.....|.:.|||..|    :.:.|::|||:.|::.:..|:... |.:.:.||.:
Human     2 AALGVQSINWQTAFNRQAHHTDKF----SSQELILRRGQNFQVLMIMNKGLG-SNERLEFIVS-- 59

  Fly   117 DDTKPSPGHGTL-NALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTK 180
              |.|.|....: .|:.|...    |.:..|.|.:::..|.|||:.|..|::.|:..:.:.:  :
Human    60 --TGPYPSESAMTKAVFPLSN----GSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMAL--Q 116

  Fly   181 LLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQF 245
            :...|..|........:|||||...|.|::.:..:|:|||..|..:|:.||.||:....|..|||
Human   117 IFSQGGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQF 181

  Fly   246 ERHVLECSLKVLGTV------GRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVA 304
            |..:|...|.:|...      .....|.|.||..|.|.|||::||.||:|||.||||..::||..
Human   182 EEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGTYTGGRD 246

  Fly   305 PTKWTGSVEILQQFYKTQKS-VKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDV 368
            |..|.||||||:.:.|:..| |::.|||.|:|.|.|..||||||||:||.::|||||..:|:|||
Human   247 PRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSAHDTDRNLSVDV 311

  Fly   369 FIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPAS 433
            :.|.....|| :.:||:||:|||||.|..|.|||    .::.||||:||||||.|..:::.||||
Human   312 YYDPMGNPLD-KGSDSVWNFHVWNEGWFVRSDLG----PSYGGWQVLDATPQERSQGVFQCGPAS 371

  Fly   434 VAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDI 498
            |..|:.||:...||..|:|||||||::.|.|:..:........::..||..||||||....|.|:
Human   372 VIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIGRYISTKAVGSNARMDV 436

  Fly   499 TDTYKHAERSEEERSTMLKALKQSR-----HAFSRYYLNDNFNDIEFDMELK--DDIKIGQSFSV 556
            ||.||:.|.|::||....|||.:.:     .|.|...|.....:.....:||  ..:.:|:..::
Human   437 TDKYKYPEGSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQEPSIIGKLKVAGMLAVGKEVNL 501

  Fly   557 VLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLS 621
            ||.:.|.|.. |...|..::...::|.|....||......:.|:|:......:::.:.:|...|.
Human   502 VLLLKNLSRD-TKTVTVNMTAWTIIYNGTLVHEVWKDSATMSLDPEEEAEHPIKISYAQYEKYLK 565

  Fly   622 SQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQ-LGEAAIVAQKELDVILRLENPLPIPLHK 685
            |....:|:|..||.| :.:...:.|..:..|.:..: |.||.:  :|.::|.:...|||..|:..
Human   566 SDNMIRITAVCKVPD-ESEVVVERDIILDNPTLTLEVLNEARV--RKPVNVQMLFSNPLDEPVRD 627

  Fly   686 GVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFT 733
            .|..|||.| :...||..:..:.....:...|...|..:|...:||.|:
Human   628 CVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFDILPSRSGTKQLLADFS 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	29/122 (24%)
		TGc	324..419	CDD:214673	51/95 (54%)
		Transglut_C	538..644	CDD:460002	23/107 (21%)
		Transglut_C	652..750	CDD:460002	23/84 (27%)
TGM3	NP_003236.3	Transglut_N	7..118	CDD:459971	29/125 (23%)
		TGc	267..357	CDD:214673	50/94 (53%)
		Transglut_C	483..588	CDD:460002	23/106 (22%)
		Transglut_C	595..692	CDD:460002	23/84 (27%)