DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and TGM2

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001310245.1	Gene:	TGM2 / 7052	HGNCID:	11778	Length:	687	Species:	Homo sapiens

Alignment Length:	718	Identity:	251/718 - (34%)
Similarity:	373/718 - (51%)	Gaps:	65/718 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 KVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHF-NRDYSPSKDAISFIFTVADDTKP 121
            :.||.||.|..:|||    |...:|.||||||:||.|.:|| .|:|..|.|:::  |:|.....|
Human     9 RCDLELETNGRDHHT----ADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLT--FSVVTGPAP 67

  Fly   122 SPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTKLLGDGS 186
            |...||.......|.::. ||   |.|.:...:..||::.:..|:..|:..::|.::......||
Human    68 SQEAGTKARFPLRDAVEE-GD---WTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGS 128

  Fly   187 RSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQFERHVLE 251
             |:.|. ...:|||.|||.|.|||:..::|:|||:.....|::||...::...|..||||..:|:
Human   129 -SFVLG-HFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILD 191

  Fly   252 CSL-------KVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPTKWT 309
            ..|       |.|...|| ..:.|..||.|.|.:|.:||..||.|||||.|..::..||:|..|.
Human   192 ICLILLDVNPKFLKNAGR-DCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWI 255

  Fly   310 GSVEILQQFYKTQ--KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFIDA 372
            |||:||:: :|..  :.||:.|||.|:.|..|:.|.||||:|::|.|:||||..::|.::.|
Human   256 GSVDILRR-WKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYF--- 316

  Fly   373 NNK--KLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVA 435
            .|:  ::..:.::.|||:|.|.|.||.||||..|    ::|||.:|.||||.|:..|..||..|.
Human   317 RNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPG----YEGWQALDPTPQEKSEGTYCCGPVPVR 377

  Fly   436 AVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITD 500
            |:|.||:...:|..|||||||||.:.|.........|.:.: :|.:|..||||:|.:.||||||.
Human   378 AIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINR-SLIVGLKISTKSVGRDEREDITH 441

  Fly   501 TYKHAERSEEERSTMLKALKQSRHAFSR-YYLNDNFNDIEFDMELKDDIKIGQS------FSVVL 558
            |||:.|.|.||           |.||:| .:||......|..|.::  |::|||      |.|..
Human   442 TYKYPEGSSEE-----------REAFTRANHLNKLAEKEETGMAMR--IRVGQSMNMGSDFDVFA 493

  Fly   559 KVSNKSESRTHMATGQISCDAVLYTGVGAVEVKT-LGFELELEPKSSDYVRMEVIFEEYYDKLSS 622
            .::|.: :..::....:....|.|.|:...|..| ....|.|||.|...|.:.:::|:|.|.|:.
Human   494 HITNNT-AEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTE 557

  Fly   623 QAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQ-LGEAAIVAQKELDVILRLENPLPIPLHKG 686
            ....::.|.......:....|:.|..:..|:||.: |||..  .:::|...:.|:||||:.|...
Human   558 SNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPK--QKRKLVAEVSLQNPLPVALEGC 620

  Fly   687 VFTVEGPGIEQPLKFKIAEIP----VGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVDGYRHYE 747
            .|||||.|:.:  :.|..|||    .|..........|.:.|...::..|.|.:|..|.|:|:..
Human   621 TFTVEGAGLTE--EQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVI 683

  Fly   748 IEP 750
            |.|
Human   684 IGP 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	41/121 (34%)
		TGc	324..419	CDD:214673	40/96 (42%)
		Transglut_C	538..644	CDD:279295	25/112 (22%)
		Transglut_C	652..750	CDD:279295	33/102 (32%)
TGM2	NP_001310245.1	Transglut_N	5..122	CDD:395697	41/122 (34%)
		TGc	269..361	CDD:214673	40/98 (41%)
		Transglut_C	473..573	CDD:395741	24/102 (24%)
		Transglut_C	587..686	CDD:395741	33/102 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160499
Domainoid	1	1.000	91	1.000	Domainoid score	I7675
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.910