DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and TGM1

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_000350.1	Gene:	TGM1 / 7051	HGNCID:	11777	Length:	817	Species:	Homo sapiens

Alignment Length:	784	Identity:	280/784 - (35%)
Similarity:	416/784 - (53%)	Gaps:	74/784 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CCQKCG-------DWKWCTSKDNEESTLRIRNANANYFTGIPQGDKTD---------GASSAVLG 55
            ||..|.       ||      ..|.|..|.|.:::.  |..|....:|         |.::|..|
Human    47 CCGCCSCRNAADDDW------GPEPSDSRGRGSSSG--TRRPGSRGSDSRRPVSRGSGVNAAGDG 103

  Fly    56 VLK--------VDLC---LEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAI 109
            .::        |||.   .:.|..||||..:    ..:.|:||||:||.:.:..:|.|. |.|.|
Human   104 TIREGMLVVNGVDLLSSRSDQNRREHHTDEY----EYDELIVRRGQPFHMLLLLSRTYE-SSDRI 163

  Fly   110 SFIFTVADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWK 174
            :....:.::  |..|.|| :.::|..    .|.:..|.|.:....||.|.:.:.......:.:::
Human   164 TLELLIGNN--PEVGKGT-HVIIPVG----KGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQ 221

  Fly   175 LDIDTKLLGDGSRSYPLPL----PIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRL 235
            ..:.|:   ..:..:.||.    .||:|||||||:|.||::..|.|:|||::::..|:.|:..::
Human   222 FTVRTQ---SDAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQI 283

  Fly   236 RPSVWKIGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFS 300
            ....|..|||:..||:..|.:|...| :|...|||||.|:|.:||:|||:||:|||:||||.|:|
Human   284 GERTWNYGQFDHGVLDACLYILDRRG-MPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYS 347

  Fly   301 GGVAPTKWTGSVEILQQFYKTQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLT 365
            .|..|:.|.||||||..:.:|..||.:.|||.|:||.||:.|.||:.:|.:|.::|||||..|||
Human   348 RGTNPSAWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLT 412

  Fly   366 VDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVG 430
            :|::.|.|.|.|:....||:||:||||:.||:||||..|    |||||||||||||.|..::..|
Human   413 MDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSG----FDGWQVVDATPQETSSGIFCCG 473

  Fly   431 PASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLKWER 495
            |.||.::|||.:...:|..|:|||||:||:||:...... .|::..:..|||.||.|||:....|
Human   474 PCSVESIKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGS-FKIVYVEEKAIGTLIVTKAISSNMR 537

  Fly   496 EDITDTYKHAERSEEERSTMLKALKQSRHAFSR---YYLNDNFNDIEFDMELKDDIKIGQSFSVV 557
            ||||..|||.|.|:.||    ||::.:....|:   |....:..|:...:|.:|.: :||...|.
Human   538 EDITYLYKHPEGSDAER----KAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAV-MGQDLMVS 597

  Fly   558 LKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLSS 622
            :.:.|.|.||..:.. .:......||||.....|....|:||.|.:||.|.|.|.::||...|..
Human   598 VMLINHSSSRRTVKL-HLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLVD 661

  Fly   623 QAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGV 687
            |.|..::.:..||::......|..||:|.||:...|..||:|.| |.:|.:..:||||:.|...|
Human   662 QGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQ-ECEVQIVFKNPLPVTLTNVV 725

  Fly   688 FTVEGPGIEQPLKFKIAEIPVGGTAAATFK--YTPPYAGRGTMLAKFTSKELDDVDGYRHYEIEP 750
            |.:||.|:::|....:.:|  ||....|.:  :.|...|...::|...|.:|..|.|....::.|
Human   726 FRLEGSGLQRPKILNVGDI--GGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAP 788

  Fly   751 RPED 754
            .|.|
Human   789 APGD 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	31/133 (23%)
		TGc	324..419	CDD:214673	52/94 (55%)
		Transglut_C	538..644	CDD:279295	30/105 (29%)
		Transglut_C	652..750	CDD:279295	31/99 (31%)
TGM1	NP_000350.1	Membrane anchorage region	1..100		13/60 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..105		12/53 (23%)
		Transglut_N	111..226	CDD:279240	31/126 (25%)
		TGc	371..462	CDD:214673	52/94 (55%)
		Transglut_C	579..683	CDD:279295	30/105 (29%)
		Transglut_C	691..788	CDD:279295	31/99 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..817		280/784 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160500
Domainoid	1	1.000	131	1.000	Domainoid score	I5146
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H306
Inparanoid	1	1.050	447	1.000	Inparanoid score	I1634
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	1	1.000	-	-		FOG0001456
OrthoInspector	1	1.000	-	-		otm41720
orthoMCL	1	0.900	-	-		OOG6_102867
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5185
SonicParanoid	1	1.000	-	-		X1344
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790