DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and TGM4

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_011532344.1	Gene:	TGM4 / 7047	HGNCID:	11780	Length:	729	Species:	Homo sapiens

Alignment Length:	754	Identity:	246/754 - (32%)
Similarity:	383/754 - (50%)	Gaps:	95/754 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SKDNEESTLRIRNANANYFTGIPQGDKTDGASSAVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEA 83
            |.|:..|..|:        |||.:           |.||.:|...:||...|||..|..::.
Human    37 SSDSPTSVSRV--------TGITE-----------LQVLHIDFLNQDNAVSHHTWEFQTSSP--- 79

  Fly    84 LVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGA 148
             |.|||:.|.|::..|:... |...:...|:...:  ||....||..|.|....|:    ..|.|
Human    80 -VFRRGQVFHLRLVLNQPLQ-SYHQLKLEFSTGPN--PSIAKHTLVVLDPRTPSDH----YNWQA 136

  Fly   149 GIESHEGQTLTVLIKPPSTCPVTEWKLDIDT--KLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLE 211
            .:::..|:.:||.:.......:.:::|::.|  .:|......      :|:||||||.:|.|::.
Human   137 TLQNESGKEVTVAVTSSPNAILGKYQLNVKTGNHILKSEENI------LYLLFNPWCKEDMVFMP 195

  Fly   212 DRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVAR 276
            |.|:||||:::||...:.|:...::...|..||||::||:|.:.:| |...:.|..|.|||.|.|
Human   196 DEDERKEYILNDTGCHYVGAARSIKCKPWNFGQFEKNVLDCCISLL-TESSLKPTDRRDPVLVCR 259

  Fly   277 ALSALVNSVDDDGVLLGNWSEDFSGGVAPTKWTGSVEILQQFYKTQKSVKFAQCWNFSGVLTTIA 341
            |:.|:::.....|||:|||:.|:.||.||.|||||..||||:|.|:::|.|.|||.|:|:|||:.
Human   260 AMCAMMSFEKGQGVLIGNWTGDYEGGTAPYKWTGSAPILQQYYNTKQAVCFGQCWVFAGILTTVL 324

  Fly   342 RSLGIPSRIITCYSSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEH 406
            |:||||:|.:|.:.|||||:.:||||.:::.|.:|:.:.|.||:||:|||.:.||:||||..|
Human   325 RALGIPARSVTGFDSAHDTERNLTVDTYVNENGEKITSMTHDSVWNFHVWTDAWMKRPDLPKG-- 387

  Fly   407 GTFDGWQVVDATPQEASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYW---RYNGPS 468
              :||||.|||||||.|..::..||:.:.|::.|||...:|..|||:|||.|:|.|   ..|| .
Human   388 --YDGWQAVDATPQERSQGVFCCGPSPLTAIRKGDIFIVYDTRFVFSEVNGDRLIWLVKMVNG-Q 449

  Fly   469 QPLKLLRKDTLAIGHLISTKAVLKWEREDITDTYKHAERSEEERSTMLKALKQSRHAF------- 526
            :.|.::..:|.:||..||||||.:..|.|||..||:.|.|.|||..|       .|||
Human   450 EELHVISMETTSIGKNISTKAVGQDRRRDITYEYKYPEGSSEERQVM-------DHAFLLLSSER 507

  Fly   527 -SRYYLNDNFNDIEFDMELKDDIKIGQS--FSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAV 588
             .|..:.:||..:...   .||:.:|.|  |:|:||....:....::..   |.:..||||....
Human   508 EHRRPVKENFLHMSVQ---SDDVLLGNSVNFTVILKRKTAALQNVNILG---SFELQLYTGKKMA 566

  Fly   589 EVKTLGFELELEPKSSDYVRMEVIFEEYYDKLSSQ------AAFQISAAAKVKD-------TDYD 640
            ::..|....:::.:.|: |.:.:..:.|.:.|:..      ..|.|:...:.|:       |.:.
Human   567 KLCDLNKTSQIQGQVSE-VTLTLDSKTYINSLAILDDEPVIRGFIIAEIVESKEIMASEVFTSFQ 630

  Fly   641 YYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPGIEQPLKFKIAE 705
            |          |:...:|.....:.|. |......:|.|.|||....|::|..||..........
Human   631 Y----------PEFSIELPNTGRIGQL-LVCNCIFKNTLAIPLTDVKFSLESLGISSLQTSDHGT 684

  Fly   706 IPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVDGYR 744
            :..|.|..:..|.||...|....:.|.:||::.:::..:
Human   685 VQPGETIQSQIKCTPIKTGPKKFIVKLSSKQVKEINAQK 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	31/122 (25%)
		TGc	324..419	CDD:214673	50/94 (53%)
		Transglut_C	538..644	CDD:279295	23/120 (19%)
		Transglut_C	652..750	CDD:279295	22/93 (24%)
TGM4	XP_011532344.1	Transglut_N	54..167	CDD:279240	31/123 (25%)
		TGc	308..398	CDD:214673	50/93 (54%)
		YebA	<311..398	CDD:224224	48/90 (53%)
		Transglut_C	632..729	CDD:279295	22/93 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160498
Domainoid	1	1.000	131	1.000	Domainoid score	I5153
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	1	1.000	-	-		FOG0001456
OrthoInspector	1	1.000	-	-		otm41720
orthoMCL	1	0.900	-	-		OOG6_102867
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11931
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.740