DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and Tgm5

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_038962007.1	Gene:	Tgm5 / 691932	RGDID:	1593350	Length:	431	Species:	Rattus norvegicus

Alignment Length:	436	Identity:	138/436 - (31%)
Similarity:	210/436 - (48%)	Gaps:	37/436 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 RSLGIPSRIITCYSSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEH 406
            |.||||:|:||.:.|.|||..:|.:|.:.|...:.|:....|::||:|||||.||.|.||..|
  Rat     2 RCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILENMKKDTVWNFHVWNECWMARKDLPPG-- 64

  Fly   407 GTFDGWQVVDATPQEASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWR-YNGPSQP 470
              :.||||:||||||.|:.:|..|||||.|:|.|::...:|..|.|:.||||.:.|. |.|..|.
  Rat    65 --YGGWQVLDATPQETSNGLYCCGPASVKAIKEGEVDLNYDTRFAFSMVNADCMSWLVYGGKEQK 127

  Fly   471 LKLLRKDTLAIGHLISTKAVLKWEREDITDTYKHAERSEEERSTMLKALK--QSRHAFSRYYLND 533
               |.:||..:|:.||||::...||:|:|:.||:.|.|.:||...||||:  |:..:...:..|.
  Rat   128 ---LHQDTATVGNFISTKSIQSDERDDVTENYKYEEGSLQERQVFLKALQKLQAGRSQGPHQANS 189

  Fly   534 N-FN-----------------------DIEFDMELKDDIKIGQSFSVVLKVSNKSESRTHMATGQ 574
            | |:                       .:....||.|..|:||..:.||...|.|.....:.. .
  Rat   190 NPFSSMPPRQDSARSPTTPSLRPSDVLQVSLKFELLDSPKMGQDINFVLLAVNMSPQFKDLKL-N 253

  Fly   575 ISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKDTDY 639
            :|..::|:.|............:.|.||.......::::.:|...||:....:|||..:.|.:..
  Rat   254 LSAQSLLHDGSPLAPFWQDTAFITLFPKEEKTYPCKILYSQYSQYLSTDKLIRISALGEEKSSPE 318

  Fly   640 DYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPGI-EQPLKFKI 703
            .........:..|.|...:..||.|.| .|.|.:...|||..|:...|.|:||.|: .:..:..|
  Rat   319 KILVNKIITLTFPGIMINVLGAAFVNQ-PLTVQVVFSNPLSEPVEDCVLTLEGSGLFRKQQRVLI 382

  Fly   704 AEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVDGYRHYEIE 749
            ..:.....|:.|.|..|..:|:..:.|...|....|:.||::..::
  Rat   383 GVLKPHNKASITLKTVPFKSGQRQIQANLRSNRFKDIKGYKNVYVD 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240
		TGc	324..419	CDD:214673	36/76 (47%)
		Transglut_C	538..644	CDD:279295	23/105 (22%)
		Transglut_C	652..750	CDD:279295	28/99 (28%)
Tgm5	XP_038962007.1	TGc	<1..75	CDD:214673	36/76 (47%)
		Transglut_C	218..317	CDD:395741	23/99 (23%)
		Transglut_C	331..428	CDD:395741	28/97 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5648
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020