Protein Alignment Tg and Tgm4

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_073204.2
• Gene: Tgm4 / 64679
• RGDID: 620785
• Length: 667
• Species: Rattus norvegicus
• Alignment Length: 716
• Identity: 233/716 - (32%)
• Similarity: 356/716 - (49%)
• Gaps: 86/716 - (12%)

  Fly    50 SSAVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFT 114
            |..:|.|..|:|..:.|...|||..:..    :.||:|||:.|.||:..||... |.|.:..||
  Rat     3 SRNMLVVYSVNLEKKLNAAAHHTIEYQT----QKLVLRRGQIFSLKVMLNRPLQ-SHDELKLIF- 61

  Fly   115 VADDTKPSPGHG----TLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKL 175
                   :.||.    |:. |.|.......|    |...|....|..:.:.:...:...|..:.:
  Rat    62 -------NTGHNMPFYTVE-LDPMTSYRSKG----WQVKIAKQSGVEVVLNVISAADAVVGRYTM 114

  Fly   176 DIDTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVW 240
            :::....|          ..::||||||.||.|::...:.|.|||::||..::.|...:::...|
  Rat   115 NVNEFDAG----------VFFLLFNPWCSDDSVFMASEEDRAEYVLNDTGYMYMGFAKQIKEKPW 169

  Fly   241 KIGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAP 305
            ..||||:::|.|..::|   ..:.|.....||.|:||:..::.:.::.|||:|||:.|:|.|.||
  Rat   170 TFGQFEKYILNCCFRLL---THLEPKEMQSPVLVSRAICTMMCAANNFGVLVGNWTGDYSNGTAP 231

  Fly   306 TKWTGSVEILQQFYKTQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFI 370
            ..|..||.||||.|.|:..|:|.|||.|||||||..|::|||:|.:|.:.|||||:.:|.||:::
  Rat   232 YVWASSVPILQQHYITRMPVRFGQCWVFSGVLTTALRAVGIPARSVTNFESAHDTEKNLRVDIYL 296

  Fly   371 DANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVA 435
            |.:.|.:...|.||:||:|||.:.||:|.||..|.    |||||:|:||||.|:..:|:||:.|:
  Rat   297 DESGKTIPHLTKDSVWNFHVWTDAWMKRQDLPQGH----DGWQVLDSTPQEISEGQFRIGPSPVS 357

  Fly   436 AVKNGDILRPFDGGFVFAEVNADKLYW--RYNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDI 498
            |::.|.:...:|..|||.|||.||..|  :.|...:...|:..:|.:||..||||.|.:..|:||
  Rat   358 AIRQGLVQIMYDTTFVFTEVNGDKYIWLVKQNQEREKNVLIAVETASIGKNISTKMVGENRRQDI 422

  Fly   499 TDTYKHAERSEEERSTMLKALKQSRHAFSRYYLNDNFNDIEFDME-LKDDIKIGQSFSVVLKVSN 562
            |..||..|.|.|||..|.||        |....:|..|.....:. |::.:::|...::.:.:..
  Rat   423 TLHYKFPEGSPEERKAMEKA--------SGKRPDDKLNSRTLHISVLQNSVELGHPINLTIVLKR 479

  Fly   563 KSESRTHMATGQ---ISC--DAVLYTG-----VGAVEVKTLGF-----ELELEPKSSDYV-RMEV 611
            |:      ||.|   |||  |...|||     :|.:: ||:..     |:.|...||.|: ::.:
  Rat   480 KT------ATPQNVNISCSLDLQTYTGNKKTNLGVIQ-KTVQIQGQESEVSLSMDSSFYIYKLGM 537

  Fly   612 IFEEYYDKLSSQAAFQISAAAKVKDTD--YDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILR 674
            :.:|...|....|....|......||.  :.|.|   |.|..|        :.....:.|.:...
  Rat   538 VDDEMVIKGFIIAEIVDSGERVATDTTLCFLYSA---FSVEMP--------STSKVNQPLTITCN 591

  Fly   675 LENPLPIPLHKGVFTVEGPGIEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDD 739
            .:|.|||||....|:||..|:.....::...:|.|.|.....:.||...|....:.||.|:::.:
  Rat   592 FKNTLPIPLTNIKFSVESLGLNNMKSWEQETVPPGKTINFQIECTPVKTGPRKFIVKFISRQVKE 656

  Fly   740 V 740
            |
  Rat   657 V 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	30/125 (24%)
		TGc	324..419	CDD:214673	48/94 (51%)
		Transglut_C	538..644	CDD:460002	28/124 (23%)
		Transglut_C	652..750	CDD:460002	22/89 (25%)
Tgm4	NP_073204.2	Transglut_N	11..117	CDD:459971	30/123 (24%)
		TGc	249..341	CDD:214673	48/95 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	430..449		9/26 (35%)
		Transglut_C	571..667	CDD:460002	25/98 (26%)