DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tg and Tgm7

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001153896.1	Gene:	Tgm7 / 640543	MGIID:	2151164	Length:	710	Species:	Mus musculus

Alignment Length:	738	Identity:	244/738 - (33%)
Similarity:	370/738 - (50%)	Gaps:	71/738 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 AVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVA 116
            |.|.:..|:|.:..|:::|||...    ....|::|||:.|.|.|.|:|.:.|.||.::|:
Mouse     5 AALELRSVELQIPRNNKDHHTEDL----GLSKLILRRGQIFILTIVFSRPFQPQKDHLTFV---- 61

  Fly   117 DDTKPSPGHGTLNALVPHDGIDYLGDTLE---WGAGIESHEGQTLTVLIKPPSTCPVTEWKLDID 178
            .:|.|.|     ..|:......:|..|..   |.|.....:..:|.|.|..|::..:..:.|.::
Mouse    62 AETGPEP-----TELLGTRATFFLAQTRPENVWSASDFMIDSNSLQVSIFSPASAVIGHYTLKLE 121

  Fly   179 TKLLGDG-SRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKI 242
            .. .|.| ..:|||. ...:|||||..:|.|||......:||:|.|...|::|..|.:....|..
Mouse   122 IS-QGQGPGVTYPLG-NFILLFNPWSTEDDVYLPSETLLREYIMSDYGFIYKGQTNSITSRPWNY 184

  Fly   243 GQFERHVLECSLKVLGT---VGRIPP---AYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSG 301
            ||||..:::...::|..   ..:.|.   :.|.:.|.|.|.:||::||.||.|||.|||.||:|.
Mouse   185 GQFEEDIVDICFEILNKSLYFLKNPSKDHSQRNNVVYVCRVVSAMINSNDDSGVLQGNWGEDYSQ 249

  Fly   302 GVAPTKWTGSVEILQQF-YKTQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLT 365
            |.:|.:|.|||.||:|: .|..:.||:.|||.|:.|:.|:.|.||:|:|:::.:.|||:|..:||
Mouse   250 GTSPLEWNGSVAILRQWSAKGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFHSAHNTDGNLT 314

  Fly   366 VDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVG 430
            :|.:.|...:.|.|:..|.|||:|||||.||.|.||..|    ::||||:|.|||:.|..::..|
Mouse   315 IDTYYDRTAEMLTAQRPDKIWNFHVWNECWMIRKDLPPG----YNGWQVLDPTPQQTSSGLFCCG 375

  Fly   431 PASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLKWER 495
            ||||.|:|.||:..|:|..||:||||||::.|.:.| .|..::|..:|..||..||||.|...||
Mouse   376 PASVKAIKEGDVQLPYDTPFVYAEVNADEVVWLFEG-GQVQEILAHNTSYIGKAISTKMVGSDER 439

  Fly   496 EDITDTYKHAERSEEERSTMLKA----LKQSRHAFSRYYL----NDNFNDIEFDMELKDDIKIGQ 552
            .|||.:||:.|.|.||||..:||    |:..|:|.|...|    |.....:...:.|......||
Mouse   440 LDITSSYKYPEGSSEERSAFIKASWKLLEPRRNASSLLDLLGSENLKAKPVRLQLHLVRAPMWGQ 504

  Fly   553 SFSVVLKVSNKSESRTHMATGQIS-----CDAVLYTGVGA-------VEVKTLGFELELE----- 600
            ...::|.| .:...|.|: .|.:.     |...|..|.|.       :....:.||.||:
Mouse   505 DLPLMLYV-QRVPVRDHV-QGSVGLTVRFCAQALLHGGGTRKPFWRHIVHLNVDFEKELQWPFLL 567

  Fly   601 PKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVA 665
            |.||           |.|||:.:...:::..|:|::|........||.:..|.:..::.|.|.|.
Mouse   568 PYSS-----------YRDKLTDERLIRVAGIAEVEETGQFILVLKDFSLEPPHLSIEVFERAEVG 621

  Fly   666 QKELDVILRLENPLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTML 729
             |.||:.:.|.|.|.:||:.....:||.| |...:...:..:..|.|.....:..|..||...:.
Mouse   622 -KALDIHITLTNTLMVPLNNCTMVLEGSGLINGQMTKDLGTLMAGHTIRIHLELYPIKAGPHQLQ 685

  Fly   730 AKFTSKELDDVDGYRHYEIEPRP 752
            ...:|.|:.::.||:...:...|
Mouse   686 VLISSSEVKEIKGYKDILVAAAP 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	32/125 (26%)
		TGc	324..419	CDD:214673	43/94 (46%)
		Transglut_C	538..644	CDD:279295	26/122 (21%)
		Transglut_C	652..750	CDD:279295	25/98 (26%)
Tgm7	NP_001153896.1	Transglut_N	8..122	CDD:279240	32/126 (25%)
		TGc	272..364	CDD:214673	43/95 (45%)
		YebA	<275..370	CDD:224224	46/98 (47%)
		Transglut_C	499..590	CDD:279295	23/103 (22%)
		Transglut_C	608..706	CDD:279295	25/98 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5823
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920