DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tg and Tgm1

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_113847.1	Gene:	Tgm1 / 60335	RGDID:	61838	Length:	824	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	281/780 - (36%)
Similarity:	414/780 - (53%)	Gaps:	71/780 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CCQKCG-----DWKWCTSKDNEESTLRIRNANANYFTGIPQGD--------------KTDGASSA 52
            || .||     ||      ..|.|..|.|..::. ..|...||              :..|.::|
  Rat    52 CC-SCGNRADDDW------GPEPSGSRSRGTSSR-GGGSRGGDSRGRDSRGGRRPESRGSGVNAA 108

  Fly    53 VLGVLK--------VDLCL---EDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSK 106
            ..|.::        |||..   :.|..||||..|    ..:.|::|||:||.:.:..||:|. |.
  Rat   109 GDGTIREGMLVVNGVDLLCSRSDQNRREHHTDEF----EYDELILRRGQPFHIILFLNREYE-SS 168

  Fly   107 DAISFIFTVADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVT 171
            |.|:....:.::  |..|.|| :.::|..    .|.:..|.|.:....|..||:.:.......:.
  Rat   169 DRIALELLIGNN--PEVGKGT-HVIIPVG----KGGSGGWKAQVTKTNGHNLTLRVHTSPNAIIG 226

  Fly   172 EWKLDIDTKLLGDGSRSYPLPL----PIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSY 232
            :::..:.|:   ..:..:.||.    .||:|||||||:|.||::..|.|:|||::::..|:.|:.
  Rat   227 KFQFTVRTR---SEAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTE 288

  Fly   233 NRLRPSVWKIGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSE 297
            .::....|..|||:..||:..|.:|...| :|...|||||.|:|.:||:|||:||:|||:|||:.
  Rat   289 AQIGERTWNYGQFDHGVLDACLYILDRRG-MPYGGRGDPVSVSRVVSAMVNSLDDNGVLIGNWTG 352

  Fly   298 DFSGGVAPTKWTGSVEILQQFYKTQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQA 362
            |:|.|..|:.|.||||||..:.:|..||.:.|||.|:||.||:.|.||:.:|.:|.::|||||..
  Rat   353 DYSRGTNPSAWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDT 417

  Fly   363 SLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMY 427
            |||:|::.|.|.|.|:....||:||:||||:.||:||||..|    |||||||||||||.|..::
  Rat   418 SLTMDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSG----FDGWQVVDATPQETSSGIF 478

  Fly   428 RVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLK 492
            ..||.||.::|||.:...:|..|:|||||:||:||:...... .|::..:..|||.||.|||:..
  Rat   479 CCGPCSVESIKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGS-FKIVYVEEKAIGTLIVTKAINS 542

  Fly   493 WEREDITDTYKHAERSEEERSTMLKALKQSRHAFSRYYLNDNFNDIEFDMELKDDIKIGQSFSVV 557
            ..|||||..|||.|.||.||..:.||....... :.|...|:..|:...:|.:|.: :||..:|.
  Rat   543 NMREDITHIYKHPEGSEAERKAVEKAAAHGSKP-NVYATRDSAEDVAMQVEAQDAV-MGQDLTVS 605

  Fly   558 LKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLSS 622
            :.::|:..||..:......| ...||||.....|....|:.|.|.:||.|.|.|.::||...|..
  Rat   606 VVLTNRGSSRRTVKLHLYLC-VTYYTGVSGPTFKETKKEVVLAPGASDTVAMPVAYKEYKPHLVD 669

  Fly   623 QAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGV 687
            |.|..::.:..||::......|..||:|.||:...|..||:|.| |.:|.:..:|||||.|...|
  Rat   670 QGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQ-ECEVQIVFKNPLPITLTNVV 733

  Fly   688 FTVEGPGIEQPLKFKIAEIPVGGTAAATFKYT--PPYAGRGTMLAKFTSKELDDVDGYRHYEIEP 750
            |.:||.|:::|....:.:|  ||....|.:.|  |...|...::|...|.:|..|.|....::.|
  Rat   734 FRLEGSGLQRPKVLNVGDI--GGNETVTLRQTFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAP 796

Fly 751 750
Rat 797 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	32/133 (24%)
		TGc	324..419	CDD:214673	52/94 (55%)
		Transglut_C	538..644	CDD:279295	29/105 (28%)
		Transglut_C	652..750	CDD:279295	33/99 (33%)
Tgm1	NP_113847.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..110		11/55 (20%)
		Transglut_N	119..234	CDD:279240	32/126 (25%)
		TGc	379..470	CDD:214673	52/94 (55%)
		Transglut_C	587..691	CDD:279295	29/105 (28%)
		Transglut_C	699..796	CDD:279295	33/99 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..824
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354563
Domainoid	1	1.000	129	1.000	Domainoid score	I5126
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H306
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1557
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	1	1.000	-	-		FOG0001456
OrthoInspector	1	1.000	-	-		otm45852
orthoMCL	1	0.900	-	-		OOG6_102867
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1344
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760