DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and F13a1

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_067730.2	Gene:	F13a1 / 60327	RGDID:	621495	Length:	732	Species:	Rattus norvegicus

Alignment Length:	735	Identity:	250/735 - (34%)
Similarity:	366/735 - (49%)	Gaps:	86/735 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LGVLKVDLCLE---DNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTV 115
            |.|..|.|..|   .|..:|||..:    ....|:||||:.|.::|.|||.|.|.||.....:.:
  Rat    46 LNVTAVHLFKERWDSNKIDHHTDKY----DNNKLIVRRGQTFYIQIDFNRPYDPRKDLFRVEYVI 106

  Fly   116 ADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKL----- 175
            .  ..|....||   .:|...:..| .:.:|||.:..:|.:::.:.::....|.|.::::
  Rat   107 G--RYPQENKGT---YIPVPVVTEL-QSGKWGAKVIMNEDRSVRLSVQSSPECIVGKFRMYVAVW 165

  Fly   176 ------------DIDTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIW 228
                        :.||                |:||||||.:|.|||:|..:|:|||::|..:|:
  Rat   166 TPYGILRTQRDPETDT----------------YILFNPWCEEDAVYLDDEKEREEYVLNDIGVIF 214

  Fly   229 RGSYNRLRPSVWKIGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLG 293
            .|.:|.::...|..||||..:|:..|.|:.. ..:..:.||:|::|:|..||:||:.||:|||:|
  Rat   215 HGDFNDIKSRSWSYGQFEDGILDACLYVMDK-AEMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVG 278

  Fly   294 NWSEDFSGGVAPTKWTGSVEILQQFYKTQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAH 358
            :|...::.|:.|:.|||||:||.::..::..|::.|||.|:||..|..|.||||:|:||.|.|||
  Rat   279 SWDNVYAYGIPPSAWTGSVDILLEYRSSETPVRYGQCWVFAGVFNTFLRCLGIPARVITNYFSAH 343

  Fly   359 DTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEAS 423
            |..|:|.:|:|::.:.......|.||:||||.|||.||.||||.||    |.|||.||:||||.|
  Rat   344 DNDANLQMDIFLEEDGSVSSKLTKDSVWNYHCWNEAWMTRPDLPVG----FGGWQAVDSTPQENS 404

  Fly   424 DNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRK-DTLAIGHLIST 487
            |.|||.|||||.|||:|.:...||..|||||||:|.:|  .........::.. |...||.||.|
  Rat   405 DGMYRCGPASVQAVKHGHVCFQFDAPFVFAEVNSDLVY--ITAKKDGTHVVENVDATHIGKLIVT 467

  Fly   488 KAVLKWEREDITDTYKHAERSEEERSTMLKALKQSRHAFSRYYLNDNFN-----------DIEFD 541
            |.:.....:|||||||..|..||||..:..||        .|......|           |:.||
  Rat   468 KEIGGDGMQDITDTYKFQEGQEEERLALETAL--------MYGAKKTLNTEGVVKSRSDVDMNFD 524

  Fly   542 MELKDDIKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDY 606
            :|   :..:|:.|.|.:...|.| |..:.....:|.:...||||...|.||..||:.|:|.|.:
  Rat   525 VE---NAVLGKDFRVTITFQNNS-SNLYTILAYLSGNITFYTGVSKKEFKTESFEVTLDPLSLE- 584

  Fly   607 VRMEVIFE--EYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKEL 669
             :.||:..  ||...|..|........|::.:|......|....:..|.:..::...|:|..
  Rat   585 -KKEVLIRAGEYMSYLLEQGLLHFFVTARINETRVVLAKQKSIVLTIPKVTIKVRGTAMVGS--- 645

  Fly   670 DVILRLE--NPLPIPLHKGVFTVEGPGIEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKF 732
            |:::.:|  |||...|......:||||:.:|.:....||....|........|..:|...::|..
  Rat   646 DMVVTVEFTNPLKETLKNVWLHLEGPGVMRPKRKMFREIRPNATVQWEEVCQPWVSGHRKLIASM 710

  Fly   733 TSKELDDVDGYRHYEIEPRP 752
            ||..|..|.|....:|..||
  Rat   711 TSDSLRHVYGELDLQIRRRP 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	33/142 (23%)
		TGc	324..419	CDD:214673	49/94 (52%)
		Transglut_C	538..644	CDD:279295	30/107 (28%)
		Transglut_C	652..750	CDD:279295	26/99 (26%)
F13a1	NP_067730.2	Transglut_N	47..164	CDD:279240	33/126 (26%)
		YebA	<280..408	CDD:224224	65/131 (50%)
		TGc	309..400	CDD:214673	49/94 (52%)
		Transglut_C	519..623	CDD:279295	31/109 (28%)
		Transglut_C	631..726	CDD:279295	25/97 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354562
Domainoid	1	1.000	129	1.000	Domainoid score	I5126
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1557
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45852
orthoMCL	1	0.900	-	-		OOG6_102867
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1344
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.760