DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm1l1

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_694950.3	Gene:	tgm1l1 / 566581	ZFINID:	ZDB-GENE-060503-139	Length:	783	Species:	Danio rerio

Alignment Length:	704	Identity:	254/704 - (36%)
Similarity:	384/704 - (54%)	Gaps:	44/704 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LGVLKVDLC---LEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTV 115
            |.|..|||.   .:.|.:||||..:    :.:.|::|||:.|::::..:|.::|:.|.:.  ..:
Zfish    99 LVVRSVDLLSRKTDRNKKEHHTDQY----SGDQLIIRRGQTFQIELELSRPFNPNTDKLH--LEL 157

  Fly   116 ADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTK 180
            .....|....|| :.::|.  ::.|.|. .|.|.|.........:.|.......:.::.|.:.|:
Zfish   158 KTGALPLVSKGT-HIIIPL--VEELQDE-RWEAKIVEQNLNRAKLSINSSVNAVIGKYTLTVVTQ 218

  Fly   181 LL-GDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQ 244
            .| .:.|.::.....||:||||||.||.|::|...:..|||::||..|:.|:..::....|..||
Zfish   219 CLKTNESTTHDPEKDIYMLFNPWCEDDAVFMEGERELNEYVLNDTGRIYYGTEKQIGARTWNFGQ 283

  Fly   245 FERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPTKWT 309
            |:..:||..|.||.. ..:||:.|||||.|.|.:||::||.||.|||.||||.:::||.:||.|:
Zfish   284 FDEGILEACLFVLDN-SEVPPSGRGDPVNVVRVISAMINSPDDRGVLEGNWSGNYTGGTSPTAWS 347

  Fly   310 GSVEILQQFYKTQKS-VKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFIDAN 373
            ||||||:|:::...: ||:.|||.||||.||:.|.||||:|.:|.:.|||||..|||.||:.|.:
Zfish   348 GSVEILKQYHREGGTPVKYGQCWVFSGVTTTVLRCLGIPARSVTNFQSAHDTDVSLTTDVYFDED 412

  Fly   374 NKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAAVK 438
            .:.:....:||:||:||||:.|:.||||..|    |.|||.||:||||.|...:|.||||:|||:
Zfish   413 MEPIHHLNSDSVWNFHVWNDCWLARPDLPPG----FGGWQAVDSTPQETSHGTFRCGPASLAAVR 473

  Fly   439 NGDILRPFDGGFVFAEVNADKLYWRYN--GPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDT 501
            :|.:...:|..|||||||:||:||:.|  |....:...:|   |:||.||||||...||.||||.
Zfish   474 SGQVYLKYDVPFVFAEVNSDKIYWQRNLDGTFSQIHSEKK---AVGHCISTKAVGSDERVDITDV 535

  Fly   502 YKHAERSEEERSTMLKALKQSRHAFSRY------YLNDNFNDIEFDMELK-DDIKIGQSFSVVLK 559
            ||:.|.|||||..:..|        .||      |.:....|::.::.:: :..::|....:.:.
Zfish   536 YKYPEGSEEERIAVETA--------CRYGSKPDVYSSAMAEDVQVEVRMEGEGPRMGGDAQLKIV 592

  Fly   560 VSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLSSQA 624
            |.|.| |:....|.......:.||||....||.....:||.|:....:...:.:.:|.::|..||
Zfish   593 VKNMS-SQPRRTTLHSQAAVMYYTGVLKDTVKKDKLSVELMPQEEKVIEWTLPYTQYQNQLVDQA 656

  Fly   625 AFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQ-LGEAAIVAQKELDVILRLENPLPIPLHKGVF 688
            |..::.:.:|.:|......|..||:|.||::.: :|||.:  .||....:...||||..|...|.
Zfish   657 ALMLTLSGRVSETQQVLANQTSFRLRTPDLQIEPIGEAYV--GKEASAKISFTNPLPCTLRNVVV 719

  Fly   689 TVEGPGIEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVDG 742
            .|||.|:......|:.::...|....|..:.|..||...::|....|:|..|.|
Zfish   720 RVEGLGLRDLHPIKVGDVGKHGKVMVTEHFIPSIAGERKLVASLDCKQLTQVHG 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	28/125 (22%)
		TGc	324..419	CDD:214673	49/95 (52%)
		Transglut_C	538..644	CDD:279295	22/106 (21%)
		Transglut_C	652..750	CDD:279295	28/92 (30%)
tgm1l1	XP_694950.3	Transglut_N	100..217	CDD:279240	28/126 (22%)
		TGc	363..454	CDD:214673	49/94 (52%)
		YebA	<365..462	CDD:224224	53/100 (53%)
		Transglut_C	572..676	CDD:279295	22/104 (21%)
		Transglut_C	684..779	CDD:279295	28/92 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596888
Domainoid	1	1.000	133	1.000	Domainoid score	I5000
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H306
Inparanoid	1	1.050	449	1.000	Inparanoid score	I1594
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	1	1.000	-	-		FOG0001456
OrthoInspector	1	1.000	-	-		otm24798
orthoMCL	1	0.900	-	-		OOG6_102867
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1344
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900