DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm5l

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001313420.1	Gene:	tgm5l / 565984	ZFINID:	ZDB-GENE-110411-176	Length:	685	Species:	Danio rerio

Alignment Length:	718	Identity:	215/718 - (29%)
Similarity:	336/718 - (46%)	Gaps:	150/718 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHF-NRDYSPSKDAISFIFTVADDTK 120
            :.|:|....|..:|.|.    ..:..:||||||:||.:.|:: .|.|.|.::.:.|||.:
Zfish     7 VSVNLQPVQNQLQHRTD----GLSSGSLVVRRGQPFTVTINYAGRPYDPLREKLQFIFIL----- 62

  Fly   121 PSPGHGTLNALVPHDGIDYLG--DTLEWGA----GIESHEG-QTLTVLIKPPSTCPVTEWKLDI- 177
                 |.|:..||   :...|  .:.:|.|    |:.:..| :.|||.:..|::..:..:.|.:
Zfish    63 -----GPLSVEVP---VSSYGQPSSSKWSAVLERGLPNPSGSRALTVSLSSPASSSIGVYTLQLT 119

  Fly   178 -------DTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRL 235
                   .|.|||.          ..:|.||||..|.|:|:..|.|.|||..|..|:::|:...:
Zfish   120 VQTRSSTKTHLLGQ----------FTLLANPWCQADSVFLQSEDLRNEYVRSDFGLLFKGTPGNV 174

  Fly   236 RPSVWKIGQFERHVLECSLKVLGTVGRIPP----------AYRGDPVRVARALSALVNSVDDDGV 290
            ....|..||:|:.:|:..:|:|    ::.|          ..|..|:.:.|.:||:||..||.||
Zfish   175 VSRPWSFGQYEKGLLDICMKLL----QLSPQSQTDMKRDLLNRSSPIYIGRVISAMVNCQDDKGV 235

  Fly   291 LLGNWSEDFSGGVAPTKWTGSVEILQQFYKTQKS-VKFAQCWNFSGVLTTIARSLGIPSRIITCY 354
            |:||||.|:|.||.|:.|:||.:||:.:.:||.| ||:||||.|:.|:.|:.|:||||:|::|.:
Zfish   236 LMGNWSGDYSDGVNPSVWSGSADILRMWSETQFSPVKYAQCWVFAAVMCTVMRALGIPTRVVTNF 300

  Fly   355 SSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATP 419
            :|||||..::.::.:.....:||.. ..|||||:|||.|.||:|||||    .|:|||||:|.||
Zfish   301 NSAHDTNGNMVIEEYYTEMGEKLSI-GRDSIWNFHVWVESWMKRPDLG----QTYDGWQVLDPTP 360

  Fly   420 QEASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNAD---------KLYWRYNGPSQPLKLLR 475
            ||.|..|||.|||:|.|:....:...:|..||:||||||         |:.    |.|
Zfish   361 QEESAGMYRCGPAAVKAIHEQKVDAAYDVPFVYAEVNADVRTVIIRDRKIL----GVS------- 414

  Fly   476 KDTLAIGHLISTKAVLKWEREDITDTYKHAERSEEERSTMLKALKQSRHAFSRYYLNDNFNDIE- 539
            .|...:|.||.||........|||..||            .:.:..|.:|||.        |:.
Zfish   415 VDKERVGALICTKRPGAMTMLDITSEYK------------TEMVLSSAYAFSA--------DVRG 459

  Fly   540 --------------FDMELKDDIKIGQS--FSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAV 588
                          ..::|.....||:|  ||:::             |.|.|...:|.....|.
Zfish   460 GEAAPARVAPQGLAVSLQLLKTPIIGESIAFSIII-------------TNQASIPKLLRAHANAQ 511

  Fly   589 EVK----TLG------FELELEPKSSDYVRMEVIFEEYYDKLSSQAA-FQISAAAKVKD--TDYD 640
            ..:    ..|      .||::.|..:..:..|:.|.||  ||..... :.::.|..|:|  :...
Zfish   512 NKEYHRNPFGSFWEKHHELKIGPSETVTINQEISFNEY--KLKQVLEDYLVNLAVVVEDVKSQER 574

  Fly   641 YYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPG-IEQPLKFKIA 704
            ..|.::|.:..|.:..|:....::.......::...||..:.: .|..||.|.| :|:.::.:::
Zfish   575 VLASEEFNIHSPALSIQIQNENVIVNSPQVAMVTFTNPFDVAV-TGELTVAGSGLLEEKIQIRVS 638

  Fly   705 EIP 707
            ..|
Zfish   639 MQP 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	34/137 (25%)
		TGc	324..419	CDD:214673	47/95 (49%)
		Transglut_C	538..644	CDD:279295	24/135 (18%)
		Transglut_C	652..750	CDD:279295	11/57 (19%)
tgm5l	NP_001313420.1	Transglut_N	5..120	CDD:279240	34/129 (26%)
		TGc	270..360	CDD:214673	46/94 (49%)
		YebA	<272..368	CDD:224224	50/100 (50%)
		Transglut_C	472..577	CDD:279295	24/119 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020