Protein Alignment Tg and tgm2l

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_687398.2
• Gene: tgm2l / 559012
• ZFINID: ZDB-GENE-050420-97
• Length: 692
• Species: Danio rerio
• Alignment Length: 735
• Identity: 242/735 - (32%)
• Similarity: 363/735 - (49%)
• Gaps: 84/735 - (11%)

  Fly    51 SAVLGVLKVDL-CLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFT 114
            :|:|.  .||| |.|:|| .|.|.....    |.|:||||:||                 |.:..
Zfish     5 NAILS--DVDLQCYENNH-AHRTEEMDV----ERLLVRRGQPF-----------------SVVLQ 45

  Fly   115 VADDTKPSPGHGTLNALVPHDG---------IDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPV 170
            ..:.....|.| .:| |:.|.|         .|...|..:|.....:.:|:.:..| ..|:..||
Zfish    46 CTEQIPQLPDH-QIN-LILHLGKNNEVVLKVSDSEQDPGKWWFSQRNAQGEVMLTL-HSPADAPV 107

  Fly   171 TEWKLDIDTKLLGDGS-RSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNR 234
            ..:.:.: ..|..||. :....|...|:||||||.||.|||...:..:||::::..::::|:::.
Zfish   108 GLYSMTV-VLLSADGEIQEQTSPQTFYLLFNPWCKDDCVYLPSEEMLQEYILNENGILYQGAWDD 171

  Fly   235 LRPSVWKIGQFERHVLECSLKVLGTVGRIPPA----------YRGDPVRVARALSALVNSVDDDG 289
            :....|..||||:.|::....||..    .||          .|..||.|:|.::|:||:.||.|
Zfish   172 ITTVPWNFGQFEKDVVDICFDVLDN----SPAALKNSEMDIFNRASPVYVSRTITAMVNANDDRG 232

  Fly   290 VLLGNWSEDFSGGVAPTKWTGSVEILQQFYKT--QKSVKFAQCWNFSGVLTTIARSLGIPSRIIT 352
            |:.|.|..::|.|||||:|||||.||:::.:.  || |::.|||.|:||..|:.|.||||:|.||
Zfish   233 VVSGRWDGEYSDGVAPTRWTGSVPILRRWSEDGGQK-VRYGQCWVFTGVACTVLRCLGIPTRCIT 296

  Fly   353 CYSSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDA 417
            .|||||||.|::.||..::...:.:.....|:|||||.|.|.||:|.||..|    :|||||:|.
Zfish   297 NYSSAHDTDANIAVDYLVNDQLESVSEGRKDTIWNYHCWVESWMKREDLPEG----YDGWQVLDP 357

  Fly   418 TPQEASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIG 482
            ||||.||.::..||..|.|||.|::...:|..|||:|||||.:.|..: |......:.:::..||
Zfish   358 TPQERSDGIFCCGPCPVRAVKEGEVGLKYDTPFVFSEVNADLIVWIVH-PDGERSEVSQNSKIIG 421

  Fly   483 HLISTKAVLKWEREDITDTYKHAERSEEERSTMLKALKQSRHAFSRYYLNDNFNDIEFDMELKDD 547
            ..||||:|....|||||..||:.|.|.:||....||.:|....      .|....:|..::....
Zfish   422 RKISTKSVYGDFREDITANYKYPEGSMKEREVYKKAGRQVGQK------KDGPGQLELFIKHAPA 480

  Fly   548 IKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGV--GAVEVKTLGFELELEPKSSDYVRME 610
            |. |..|.|:::|.|.....|. |...::.:|:.|..:  |..:.||....:.......:.:|::
Zfish   481 IH-GTDFDVIIEVYNAGREDTD-AKLTVTSNAITYNSIHRGECQRKTTSLTVPAYKAHKEVLRLQ 543

  Fly   611 VIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRL 675
              ::.|...:|.....:::|..:..|.|.....:.:..::.|.:..::...|||::| |...:..
Zfish   544 --YDHYGACVSEHHMIRVTALLQPNDQDNLILQETNIPLKMPALHVKIIGNAIVSRK-LTAHISF 605

  Fly   676 ENPLPIPLHKGVFTVEGPGIEQPLKFKI-AEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDD 739
            .|||||.|..|||||||.|:.:..:.|. .:|..|.|....|.:.|..||...:|..|.|..|.|
Zfish   606 TNPLPINLQGGVFTVEGAGLTEAREIKTHGKIESGQTVTVKFSFKPTRAGLRKLLVDFDSDRLRD 670

  Fly   740 VDG---------YRHYEIEP 750
            |.|         .||....|
Zfish   671 VKGEASVIVRTRMRHVNAVP 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	32/131 (24%)
		TGc	324..419	CDD:214673	46/94 (49%)
		Transglut_C	538..644	CDD:460002	20/107 (19%)
		Transglut_C	652..750	CDD:460002	37/107 (35%)
tgm2l	XP_687398.2	Transglut_N	10..114	CDD:459971	32/128 (25%)
		TGc	267..359	CDD:214673	48/96 (50%)
		Transglut_C	583..679	CDD:460002	35/96 (36%)