DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm2l

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_021328950.1	Gene:	tgm2l / 559012	ZFINID:	ZDB-GENE-050420-97	Length:	692	Species:	Danio rerio

Alignment Length:	735	Identity:	242/735 - (32%)
Similarity:	363/735 - (49%)	Gaps:	84/735 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 SAVLGVLKVDL-CLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFT 114
            :|:|.  .||| |.|:|| .|.|.....    |.|:||||:||                 |.:..
Zfish     5 NAILS--DVDLQCYENNH-AHRTEEMDV----ERLLVRRGQPF-----------------SVVLQ 45

  Fly   115 VADDTKPSPGHGTLNALVPHDG---------IDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPV 170
            ..:.....|.| .:| |:.|.|         .|...|..:|.....:.:|:.:..| ..|:..||
Zfish    46 CTEQIPQLPDH-QIN-LILHLGKNNEVVLKVSDSEQDPGKWWFSQRNAQGEVMLTL-HSPADAPV 107

  Fly   171 TEWKLDIDTKLLGDGS-RSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNR 234
            ..:.:.: ..|..||. :....|...|:||||||.||.|||...:..:||::::..::::|:::.
Zfish   108 GLYSMTV-VLLSADGEIQEQTSPQTFYLLFNPWCKDDCVYLPSEEMLQEYILNENGILYQGAWDD 171

  Fly   235 LRPSVWKIGQFERHVLECSLKVLGTVGRIPPA----------YRGDPVRVARALSALVNSVDDDG 289
            :....|..||||:.|::....||..    .||          .|..||.|:|.::|:||:.||.|
Zfish   172 ITTVPWNFGQFEKDVVDICFDVLDN----SPAALKNSEMDIFNRASPVYVSRTITAMVNANDDRG 232

  Fly   290 VLLGNWSEDFSGGVAPTKWTGSVEILQQFYKT--QKSVKFAQCWNFSGVLTTIARSLGIPSRIIT 352
            |:.|.|..::|.|||||:|||||.||:::.:.  || |::.|||.|:||..|:.|.||||:|.||
Zfish   233 VVSGRWDGEYSDGVAPTRWTGSVPILRRWSEDGGQK-VRYGQCWVFTGVACTVLRCLGIPTRCIT 296

  Fly   353 CYSSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDA 417
            .|||||||.|::.||..::...:.:.....|:|||||.|.|.||:|.||..|    :|||||:|.
Zfish   297 NYSSAHDTDANIAVDYLVNDQLESVSEGRKDTIWNYHCWVESWMKREDLPEG----YDGWQVLDP 357

  Fly   418 TPQEASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIG 482
            ||||.||.::..||..|.|||.|::...:|..|||:|||||.:.|..: |......:.:::..||
Zfish   358 TPQERSDGIFCCGPCPVRAVKEGEVGLKYDTPFVFSEVNADLIVWIVH-PDGDRSEVSQNSKIIG 421

  Fly   483 HLISTKAVLKWEREDITDTYKHAERSEEERSTMLKALKQSRHAFSRYYLNDNFNDIEFDMELKDD 547
            ..||||:|....|||||..||:.|.|.:||....||.:|....      .|....:|..::....
Zfish   422 RKISTKSVYGDFREDITANYKYPEGSMKEREVYKKAGRQVGQK------KDGPGQLELFIKHAPA 480

  Fly   548 IKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGV--GAVEVKTLGFELELEPKSSDYVRME 610
            |. |..|.|:::|.|.....|. |...::.:|:.|..:  |..:.||....:.......:.:|::
Zfish   481 IH-GTDFDVIIEVYNAGREDTD-AQLTVTSNAITYNSIHRGECQRKTTSLTVPAYKAHKEVLRLQ 543

  Fly   611 VIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRL 675
              ::.|...:|.....:::|..:..|.|.....:.:..::.|.:..::...|||::| |...:..
Zfish   544 --YDHYGACVSEHHMIRVTALLQPNDQDNLILQETNIPLKMPALHVKIIGNAIVSRK-LTAHISF 605

  Fly   676 ENPLPIPLHKGVFTVEGPGIEQPLKFKI-AEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDD 739
            .|||||.|..|||||||.|:.:..:.|. .:|..|.|....|.:.|..||...:|..|.|..|.|
Zfish   606 TNPLPINLQGGVFTVEGAGLTEAREIKTHGKIESGQTVTVKFSFKPTRAGLRKLLVDFDSDRLRD 670

  Fly   740 VDG---------YRHYEIEP 750
            |.|         .||....|
Zfish   671 VKGEASVIVRTRMRHVNAVP 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	32/132 (24%)
		TGc	324..419	CDD:214673	46/94 (49%)
		Transglut_C	538..644	CDD:279295	20/107 (19%)
		Transglut_C	652..750	CDD:279295	37/107 (35%)
tgm2l	XP_021328950.1	Transglut_N	8..114	CDD:307149	33/132 (25%)
		TGc	267..359	CDD:214673	48/96 (50%)
		Transglut_C	583..679	CDD:307191	35/96 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596882
Domainoid	1	1.000	116	1.000	Domainoid score	I5898
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.810