DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm2a

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001004647.1	Gene:	tgm2a / 447909	ZFINID:	ZDB-GENE-040912-78	Length:	679	Species:	Danio rerio

Alignment Length:	737	Identity:	243/737 - (32%)
Similarity:	364/737 - (49%)	Gaps:	103/737 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 VLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNR-DYSPSKDAISFIFTVA 116
            |:.:..:||..|.|:..||| |....   :.|:||||:.|.:.:|... .:..:.|.|.||
Zfish     4 VVEIGSIDLACEVNNTNHHT-HLNGV---DRLIVRRGQTFTIHLHLKEGTHFQNGDNIKFI---- 60

  Fly   117 DDTKPSP-------GHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWK 174
            ..|.|.|       ...:|:.::         ..|.|.|..|:| ..|:::.|...:..||..:.
Zfish    61 AQTGPIPSVEAQTKARFSLSKVI---------SRLSWSATAETH-NSTVSLSICAHTNAPVGRYT 115

  Fly   175 LDIDTKLLGDGSRSYPLPLPIYV-LFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPS 238
            |.:|.   |||     :.|..:| |||||...|.|||.:..:|:|||:....||:||:..|:...
Zfish   116 LILDQ---GDG-----VILGEFVLLFNPWGKLDSVYLANEAEREEYVLSQDGLIYRGTPKRITVL 172

  Fly   239 VWKIGQFERHVLECSLKVLGTVGRIPPAY----------RGDPVRVARALSALVNSVDDDGVLLG 293
            .|..||||..:|:..|::|..    .|.|          |.:.|.|.|.|||::||:.|.||::|
Zfish   173 PWTFGQFEHGILDICLQILDE----SPNYISDAALDCSERKNAVYVTRVLSAMINSLGDKGVVVG 233

  Fly   294 NWSEDFSGGVAPTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSA 357
            |||:|:..||.||.|..|..||:|:.... ::|::.|||.|:.|..|::|:||||.|:||.:.||
Zfish   234 NWSDDYEDGVKPTVWKDSCSILRQWSNEGCRAVRYGQCWVFAAVACTVSRALGIPCRVITNFGSA 298

  Fly   358 HDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEA 422
            .|:...|.::.|.:..::.:   ..|||||||||.|.||.||||.:|    ::|||..|.|||..
Zfish   299 RDSNGDLIMERFYNEFDENI---ADDSIWNYHVWVENWMTRPDLALG----YEGWQASDPTPQHR 356

  Fly   423 SDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKL-------LRKDTLA 480
            ||.::..|||||.|:|.|::...||..||:||||||.:.:        :||       :...|..
Zfish   357 SDGVFCCGPASVRAIKEGELTFKFDVPFVYAEVNADVVEY--------IKLRDGRVFKMGGSTTE 413

  Fly   481 IGHLISTKAVLKWEREDITDTYKHAERSEEERSTMLKALKQSRHAFSRYYLNDNFNDIEFDMELK 545
            ||..||||||.:.||||||..||:.|.|||||    |..|::.| .::.........:...:.:.
Zfish   414 IGKSISTKAVGRDEREDITHNYKYPEGSEEER----KVFKKANH-HNKLAQAGEEPGLHIKIRVT 473

  Fly   546 DDIKIGQSFSVVLKVSNKSESRTHMATGQISC------DAVLYTG-VGAVEVKTLGFELELEPKS 603
            .|::||..|.|..::.|.:     |.|.  ||      .||.|.| :|  |...||...|:...|
Zfish   474 PDMQIGSDFDVYAEIKNNT-----MVTK--SCRVMFYAQAVSYNGTLG--ETCGLGDFTEMSLAS 529

  Fly   604 SD--YVRMEVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQ-LGEAAIVA 665
            ||  .|.:.:.:.||...::.....::.......:|...|.|:....:..|:|... ||...:
Zfish   530 SDGGKVTLRLEYAEYSKAITQDRMIKLVGLLIDAETREFYRAKKTIVLDAPEIIVNILGVPKV-- 592

  Fly   666 QKELDVILRLENPLPIPLHKGVFTVEGPGIE--QPLKFKIAEIPVGGTAAATFKYTPPYAGRGTM 728
            .:.|...|.|:||||.||...|||:.|..:.  :|:..::..|.....|.|..::.|...|:..:
Zfish   593 GRNLVADLALQNPLPEPLENCVFTIHGANLTDGKPITHEVGTIGPKEFATAKVEFAPKLPGQRKL 657

  Fly   729 LAKFTSKELDDVDGYRH---YE 747
            :..|.|.:|.:::.|.:   ||
Zfish   658 IIDFASDKLHNIETYENLVIYE 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	33/130 (25%)
		TGc	324..419	CDD:214673	41/94 (44%)
		Transglut_C	538..644	CDD:279295	27/114 (24%)
		Transglut_C	652..750	CDD:279295	29/102 (28%)
tgm2a	NP_001004647.1	Transglut_N	6..119	CDD:279240	33/130 (25%)
		TGc	263..353	CDD:214673	41/96 (43%)
		Transglut_C	466..561	CDD:279295	25/103 (24%)
		Transglut_C	580..677	CDD:279295	27/98 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596880
Domainoid	1	1.000	99	1.000	Domainoid score	I6999
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.910