DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and Tgm3

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_038961528.1	Gene:	Tgm3 / 366189	RGDID:	1561831	Length:	695	Species:	Rattus norvegicus

Alignment Length:	707	Identity:	240/707 - (33%)
Similarity:	368/707 - (52%)	Gaps:	55/707 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 SAVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTV 115
            |..|.|..::..:..|...|||..|    :.:..:||||:|:.:.:..||... |.|.::||.:
  Rat     3 SDALEVQNINWQMPMNRRAHHTDKF----SSQDFIVRRGQPWEVILLCNRSLE-SGDNLNFIVS- 61

  Fly   116 ADDTKPSPGHGT-LNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDT 179
               |.|.|.... ..|:....|    .:|..|.|.:::..|..|.:.|..|.:.|:..:.|:::.
  Rat    62 ---TGPQPSESARTKAVFSISG----RNTSGWSAALKASNGNNLFIAIASPVSAPIGLYTLNVEV 119

  Fly   180 KLLGDGSRSYPLPLPIY-VLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIG 243
            ...|   |...:.|..: ||||||...|.|::.:..:|:|||..|:.:|:.||.||:....|..|
  Rat   120 SSKG---RVSSVKLGTFTVLFNPWQQGDDVFMSNHAERQEYVEEDSGIIYVGSTNRIGMVGWNFG 181

  Fly   244 QFERHVLECSLKVLG---TVGRIPP---AYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGG 302
            |||..:|..||.:|.   ...|.|.   |.|.||..|.|.|||::|:.||.|||.||||.::|||
  Rat   182 QFEEDILSISLSILDRSLNFRRDPATDVARRNDPKYVCRVLSAMINANDDSGVLSGNWSGNYSGG 246

  Fly   303 VAPTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTV 366
            |.|..|.||||||:.:.|:. :.|:|.|||.|:|.|.|:.|.||:|||:||.::|||||..:|:|
  Rat   247 VDPRTWNGSVEILKNWKKSGFRPVQFGQCWVFAGTLNTVLRCLGVPSRVITNFNSAHDTDRNLSV 311

  Fly   367 DVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGP 431
            ||:.||....|: :.:||:||:|||||.|..|.|||    .:::||||:||||||.|..:::.||
  Rat   312 DVYYDAMGNPLE-KGSDSVWNFHVWNEGWFVRTDLG----PSYNGWQVLDATPQERSQGVFQCGP 371

  Fly   432 ASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLKWERE 496
            |||.|:|:|::.:.||..|:|||||||::.|.||......|....||.:||..||||||....|.
  Rat   372 ASVNAIKDGEVDQNFDMIFIFAEVNADRITWIYNNRDGSQKQNSVDTYSIGKYISTKAVGSNSRM 436

  Fly   497 DITDTYKHAERSEEERSTMLKALKQSRHAFSRYYLNDNFN--------------DIEFDMELKDD 547
            |:|..|||.|.|:|||....||:.:.:.       |.:|.              .|....::...
  Rat   437 DVTIKYKHPEGSKEERQVQQKAMNKLKP-------NASFGATSSRGPQGEEKEPSISGKFKVTGV 494

  Fly   548 IKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVI 612
            :.:|:..|:.|.:.|.:..|..:.| .::...::|.|....||......:.|:|:......:::.
  Rat   495 LAVGKEVSLALILKNTTSDRKTVTT-NMTAWTIVYNGTLVHEVWKDSATISLDPEEEIQYPVKIA 558

  Fly   613 FEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLEN 677
            :.:|...|.:....:|:|..||.| :.:...:.|..:..|.:..::.:.|.: :|.:.|.:...|
  Rat   559 YSQYDRYLKADNMIRITAVCKVPD-EAEVVVERDVILDNPTLTLEVLDQAQL-RKPVVVQMLFSN 621

  Fly   678 PLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFT 733
            ||..|:...|..|||.| :...||..:..:.....:...|:..|...|...:||.|:
  Rat   622 PLDEPVKNCVLMVEGSGLLRGSLKIDVPALRPKEKSRVRFEIFPTRIGIKQLLADFS 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	31/123 (25%)
		TGc	324..419	CDD:214673	49/94 (52%)
		Transglut_C	538..644	CDD:279295	20/105 (19%)
		Transglut_C	652..750	CDD:279295	21/83 (25%)
Tgm3	XP_038961528.1	Transglut_N	6..120	CDD:395697	32/126 (25%)
		TGc	267..359	CDD:214673	49/96 (51%)
		Transglut_C	485..590	CDD:395741	20/106 (19%)
		Transglut_C	597..693	CDD:395741	21/83 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7212
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020